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    TMEM173 transmembrane protein 173 [ Homo sapiens ]

    Gene ID: 340061, updated on 19-May-2012
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    Summary

    Official Symbol
    TMEM173provided by HGNC
    Official Full Name
    transmembrane protein 173provided by HGNC
    Primary source
    HGNC:27962
    See related
    Ensembl:ENSG00000184584; HPRD:14173; MIM:612374; Vega:OTTHUMG00000129239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERIS; MITA; MPYS; NET23; STING; FLJ38577
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    Genomic context

    Location :
    5q31.2
    Sequence :
    Chromosome: 5; NC_000005.9 (138855113..138862343, complement)
    See TMEM173 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene nuclear receptor coactivator 4 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2D 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    2. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Zhang Z, et al. Nat Immunol, 2011 Sep 4. PMID 21892174.
    3. Identification and characterization of a loss-of-function human MPYS variant. Jin L, et al. Genes Immun, 2011 Jun. PMID 21248775.
    4. Cellular reactive oxygen species inhibit MPYS induction of IFNβ. Jin L, et al. PLoS One, 2010 Dec 10. PMID 21170271.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA.
      Title: The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.
    2. R71H-G230A-R293Q haplotype MPYS exhibits a > 90% loss in the ability to stimulate IFNbeta production
      Title: Identification and characterization of a loss-of-function human MPYS variant.
    3. Cellular reactive oxygen species inhibit MPYS induction of IFNbeta
      Title: Cellular reactive oxygen species inhibit MPYS induction of IFNβ.
    4. dimerization of ERIS was critical for self-activation and subsequent downstream signaling
      Title: ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
    5. E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner
      Title: The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
    7. results suggest MITA is a critical mediator of virus-triggered IRF3 activation and IFN expression and further demonstrate the importance of certain mitochondrial proteins in innate antiviral immunity.
      Title: The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
    8. identification, following expression cloning, of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes
      Title: STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
    9. STING (TMEM173) is an endoplasmic reticulum adaptor protein that facilitates innate immune signaling
      Title: STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:130988 BioGRID:110503 ABCC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:108477 ACSL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:124814 C19orf6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:121318 CCDC47    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:123354 CLPTM1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:117712 CNNM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:108017 DDOST    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:116318 GLMN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:123505 HM13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:117509 LTN1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:122562 MBOAT7    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:110925 NPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:111975 RNF5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:130988 BioGRID:118968 SEC61A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:114398 SGPL1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:117063 SLC39A14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:109908 STT3A    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:128394 STT3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:130988 BioGRID:112703 SURF4    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:130988 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:130988 BioGRID:130988 TMEM173    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:130988 BioGRID:123596 TRIM56    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:130988 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:130988 BioGRID:123519 YIPF5    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    		  
    innate immune response IDA
    Inferred from Direct Assay
    more info
    		  
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    interferon-beta production IDA
    Inferred from Direct Assay
    more info
    		  
    interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein import into nucleus, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription factor import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    transmembrane protein 173
    Names
    transmembrane protein 173
    hMITA
    hSTING
    mediator of IRF3 activation
    endoplasmic reticulum IFN stimulator
    stimulator of interferon genes protein
    mitochondrial mediator of IRF3 activation
    endoplasmic reticulum interferon stimulator
    N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198282.2 → NP_938023.1  transmembrane protein 173

      Status: VALIDATED

      Source sequence(s)
      BC047779, BM149879, BU731116
      Consensus CDS
      CCDS4215.1
      UniProtKB/Swiss-Prot
      Q86WV6
      Related
      ENSP00000331288, OTTHUMP00000159544, ENST00000330794, OTTHUMT00000251338

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      138855113..138862343, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      133997951..134005182, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC138517.2 (18474..25217) None
    genomic CH471062.2 EAW62098.1
      EAW62099.1
      EAW62100.1
    mRNA AK095896.1 None
    mRNA AK129800.1 None
    mRNA AK290661.1 BAF83350.1
    mRNA AX775913.1 CAE11656.1
    mRNA BC047779.1 AAH47779.1
    mRNA BM149879.1 None
    mRNA BU731116.1 None
    mRNA FJ222241.1 ACI46648.1
    other-genetic HQ448605.1 ADQ33083.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86WV6.1 GenPept UniProtKB/Swiss-Prot:Q86WV6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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