ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein [Homo sapiens (human)] - Gene

Summary

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Official Symbol: ID4provided by HGNC
Official Full Name: inhibitor of DNA binding 4, dominant negative helix-loop-helix proteinprovided by HGNC
Primary source: HGNC:5363
See related: HPRD:08995; MIM:600581
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IDB4; bHLHb27
Summary: This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]

Genomic context

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Location :: 6p22.3

Sequence :: Chromosome: 6; NC_000006.11 (19837601..19842431)

See ID4 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that methylation of Id4 may be involved in the pathogenesis of GBM and in the resistance of this neoplasm to conventional treatment throughout MGP-mediated neoangiogenesis.
Title: Epigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis.
Id4 overexpression plays a role in the downregulation of BRCA1 in sporadic TNBCs of patients without BRCA1 germline mutation, and provide new insight into the biology of these tumors.
Title: Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation.
ID4 downregulation may contribute to prostate cancer pathogenesis and is often accompanied by DNA hypermethylation.
Title: ID4 is frequently downregulated and partially hypermethylated in prostate cancer.
methyltransferase inhibitor 5-Aza-CdR can re-express the silent ID4 gene in K562 cells
Title: [Effect of 5-Aza-CdR on biological activity and inhibitor of DNA binding 4 gene expression in human erythroleukemia cell line K562].
Id2 and Id4 regulated glioblastoma multiforme neurosphere differentiation through downregulating of another bHLH family member, the oligodendroglial lineage-associated transcription factors (Olig) 1 and 2
Title: Regulation of glioblastoma multiforme stem-like cells by inhibitor of DNA binding proteins and oligodendroglial lineage-associated transcription factors.
Results showed that DPP6, SPHKAP and ID4 were down regulated in acute myeloid leukemia (AML) patients.
Title: Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.
Compared with ron deficiency anemia patients, ID4 gene methylation changes of different degrees occur in AML patients with different subtypes and stages.
Title: [ID4 promoter methylation in acute myeloid leukemia].
Hypermethylation of the promoter was associated with loss of inhibitor of differentiation 4 (ID4) messenger RNA and protein expression.
Title: Parakeratosis in skin is associated with loss of inhibitor of differentiation 4 via promoter methylation.
The zo-1 and id4 genes in multiple myeloma cell lines all were methylation positive, and the methylation positive rates were significantly higher than in normal bone marrow.
Title: [Clinical significance of zo-1 and id4 gene abnormal methylation in multiple myeloma].
The id4 gene promoter in CML patients is unmethylated in chronic phase, but it is methylated in accelerated phase and blast crisis.
Title: [Methylation status of id4 gene promoter in patients with chronic myeloid leukemia].

Submit: New GeneRIF Correction See all (34)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Genome-wide association of lipid-lowering response to statins in combined study populations.

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P47928	Q14469	HES1	HPRD	PubMed
P47928	Q02535	ID3	HPRD	PubMed
P47928	P15172	MYOD1	HPRD	PubMed
P47928	P15884	TCF4	HPRD	PubMed
BioGRID:109626	BioGRID:112791	TCF3	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

General gene information

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Markers

AL020973 (e-PCR)
- UniSTS:41253

A007A41 (e-PCR)
- UniSTS:61993

WI-13751 (e-PCR)
- UniSTS:83553

D6S1228E (e-PCR)
- UniSTS:55652

WI-7424 (e-PCR)
- UniSTS:30329

RH91195 (e-PCR)
- UniSTS:86707

ID4_2076 (e-PCR)
- UniSTS:280772

RH46626 (e-PCR)
- UniSTS:44231

Idb4 (e-PCR), detects polymorphism
- UniSTS:256475

Homology

Homologs of the ID4 gene: The ID4 gene is conserved in Rhesus monkey, mouse, rat, and zebrafish.
Map Viewer (Mouse, Rat)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
RNA polymerase II transcription factor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	IEA Inferred from Electronic Annotation more info
transcription corepressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
cellular protein localization	IEA Inferred from Electronic Annotation more info
central nervous system myelination	IEA Inferred from Electronic Annotation more info
cerebral cortex neuron differentiation	IEA Inferred from Electronic Annotation more info
fat cell differentiation	IEA Inferred from Electronic Annotation more info
hippocampus development	IEA Inferred from Electronic Annotation more info
negative regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
neuroblast proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-4

Names: DNA-binding protein inhibitor ID-4; class B basic helix-loop-helix protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001546.3 → NP_001537.1 DNA-binding protein inhibitor ID-4

Status: VALIDATED

Source sequence(s)

AI692586, AL022726, BC014941, DB461864

Consensus CDS

CCDS4544.1

UniProtKB/Swiss-Prot

P47928

Conserved Domains (1) summary

cd00083
Location:66 – 109
Blast Score: 163

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p10 Primary Assembly

Range

19837601..19842431

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

19782014..19786844

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018917.1 Alternate CHM1_1.0

Range

19759835..19764665

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01022246.1 (40030..44860)	None
genomic	AL022726.1 (68181..73011)	None
genomic	AMYH01016132.1 (8399..13229)	None
genomic	CH471087.1	EAW55416.1
mRNA	AI692586.1	None
mRNA	AJ420553.1	None
mRNA	AK130851.1	None
mRNA	BC014941.1	AAH14941.1
mRNA	DB461864.1	None
mRNA	U16153.1	AAA82882.1
mRNA	U28368.1	AAA73923.1
mRNA	Y07958.1	CAA69255.1