ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: ID2provided by HGNC
Official Full Name: inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinprovided by HGNC
Primary source: HGNC:5361
See related: Ensembl:ENSG00000115738; HPRD:02664; MIM:600386
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GIG8; ID2A; ID2H; bHLHb26; MGC26389
Summary: The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

Help top of page

Genomic context

Location :: 2p25

Sequence :: Chromosome: 2; NC_000002.11 (8822113..8824583)

See ID2 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate that Id2 functions as a proproliferative gene that antagonizes p53-mediated cell cycle regulation in NPCs and may contribute to the malignant proliferation of glioma-derived tumor stem cells.
Title: p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells.
Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation.
Title: Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation.
AMP-activated protein kinase (PRKAA1/2, aka AMPK) mediates the stress-induced proteasome-dependent loss of ID2 at high stress levels.
Title: Cellular stress causes reversible, PRKAA1/2-, and proteasome-dependent ID2 protein loss in trophoblast stem cells.
expression of vFLIP decreased the expression levels of Id2 and Id3 as well as cyclin E and cyclin A compared with the vFLIP-null cells
Title: Human herpesvirus 8 viral FLICE-inhibitory protein retards cell proliferation via downregulation of Id2 and Id3 expression.
ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression
Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.
Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via PRC2 which therefore contributes to T-cell leukemogenesis.
Title: Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines.
T cell development is impaired by Id2, most likely by sequestering HEB, whereas NK cell development is promoted by increasing a pool of CD1a-CD5+ NK cell progenitors, which together with IL-15 differentiate into mature NK cells
Title: Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development.
VEGF165 may partially inhibit TGF-beta1-induced epithelial-mesenchymal transition by upregulating the expressions of BMP-7 and Id2.
Title: [Relationship between the effect of vascular endothelial growth factor on epithelial-mesenchymal transition of HK-2 cells and the expressions of bone morphogenetic protein-7 and inhibitor of DNA binding/differentiation].
Metastatic tumor cells overexpress c-myc, leading to upregulation of Id2 expression; the aberrantly elevated amount of Id2 represses SEMA3F expression and, as a consequence, enhances the ability of tumor cells to migrate and invade.
Title: Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F.

Submit: New GeneRIF Correction See all (56)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Q02363	P35611	ADD1	HPRD	PubMed
Q02363	P24941	CDK2	HPRD	PubMed
Q02363	P19419	ELK1	HPRD	PubMed
Q02363	P41970	ELK3	HPRD	PubMed
Q02363	P28324	ELK4	HPRD	PubMed
Q02363	Q14469	HES1	HPRD	PubMed
Q02363	Q02363	ID2	HPRD	PubMed
Q02363	Q16666	IFI16	HPRD	PubMed
Q02363	Q5T3J3	LRIF1	HPRD	PubMed
Q02363	O60682	MSC	HPRD	PubMed
Q02363	P13349	MYF5	HPRD	PubMed
Q02363	P23409	MYF6	HPRD	PubMed
Q02363	P15172	MYOD1	HPRD	PubMed
Q02363	P15173	MYOG	HPRD	PubMed
Q02363	Q14511	NEDD9	HPRD	PubMed
Q02363	Q02962	PAX2	HPRD	PubMed
Q02363	Q02548	PAX5	HPRD	PubMed
Q02363	Q06710	PAX8	HPRD	PubMed
Q02363	P62136	PPP1CA	HPRD	PubMed
Q02363	P06400	RB1	HPRD	PubMed
Q02363	P28749	RBL1	HPRD	PubMed
Q02363	Q08999	RBL2	HPRD	PubMed
Q02363	Hypothetical protein DKFZp564O0523	RBM48	HPRD	PubMed
Q02363	Q99081	TCF12	HPRD	PubMed
Q02363	P15923	TCF3	HPRD	PubMed
Q02363	P15884	TCF4	HPRD	PubMed
Q02363	Q13432	UNC119	HPRD	PubMed
BioGRID:109624	BioGRID:106631	ADD1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109624	BioGRID:114934	BCAR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109624	BioGRID:108206	E2F4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109624	BioGRID:122060	ELSPBP1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109624	BioGRID:108896	GATA4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109624	BioGRID:120905	LRIF1	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:111580	MAPK1	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:111581	MAPK3	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:114669	MSC	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:110702	MYF5	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:110703	MYF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109624	BioGRID:110737	MYOD1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109624	BioGRID:110816	NEDD9	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109624	BioGRID:107864	NKX2-5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109624	BioGRID:111869	RBL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109624	BioGRID:123855	RBM48	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109624	BioGRID:112798	TCF12	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:112791	TCF3	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:112787	TCF4	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109624	BioGRID:114548	UNC119	BioGRID	PubMed	Two-hybrid
BioGRID:109624	BioGRID:113241	USP1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ion channel binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Peyer's patch development	IEA Inferred from Electronic Annotation more info
adipose tissue development	IEA Inferred from Electronic Annotation more info
bundle of His development	IEA Inferred from Electronic Annotation more info
cell maturation	IEA Inferred from Electronic Annotation more info
cellular response to lithium ion	IEA Inferred from Electronic Annotation more info
cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
embryonic digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
endodermal digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
entrainment of circadian clock	IEA Inferred from Electronic Annotation more info
enucleate erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
epithelial cell differentiation involved in mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
heart development	IEA Inferred from Electronic Annotation more info
leukocyte differentiation	IEA Inferred from Electronic Annotation more info
mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
mammary gland epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
metanephros development	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of DNA binding	IEA Inferred from Electronic Annotation more info
negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
neuron fate commitment	ISS Inferred from Sequence or Structural Similarity more info
olfactory bulb development	IEA Inferred from Electronic Annotation more info
oligodendrocyte development	IEA Inferred from Electronic Annotation more info
positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cell cycle	IEA Inferred from Electronic Annotation more info
positive regulation of cell cycle arrest	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription involved in G1/S phase of mitotic cell cycle	IC Inferred by Curator more info	PubMed
positive regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromatin	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
protein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: DNA-binding protein inhibitor ID-2

Names: DNA-binding protein inhibitor ID-2; helix-loop-helix protein ID2; cell growth-inhibiting gene 8; inhibitor of differentiation 2; DNA-binding protein inhibitor ID2; class B basic helix-loop-helix protein 26

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002166.4 → NP_002157.2 DNA-binding protein inhibitor ID-2

Status: REVIEWED

Source sequence(s)

BC030639, BE222494

Consensus CDS

CCDS1659.1

UniProtKB/Swiss-Prot

Q02363

UniProtKB/TrEMBL

Q53T66

Related

ENSP00000379585, ENST00000396290

Conserved Domains (1) summary

cd00083
Location:38 – 80
Blast Score: 131

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

8822113..8824583

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

8668297..8670767

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011747.8	AAY14810.1
genomic	CH471053.2	EAX01018.1
		EAX01019.1
mRNA	AK222682.1	BAD96402.1
mRNA	AK311988.1	BAG34927.1
mRNA	AY634687.1	AAV35470.1
mRNA	BC030639.2	AAH30639.1
mRNA	BE222494.1	None
mRNA	D13891.1	BAA02990.1
mRNA	M97796.1	AAA58681.1
other-genetic	DQ890858.2	ABM81784.1
other-genetic	DQ894013.2	ABM84939.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q02363.1	GenPept	UniProtKB/Swiss-Prot:Q02363
Q53H99	GenPept	UniProtKB/TrEMBL:Q53H99
Q53T66	GenPept	UniProtKB/TrEMBL:Q53T66