ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein [Homo sapiens] - Gene

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Summary

Official Symbol: ID1provided by HGNC
Official Full Name: inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinprovided by HGNC
Primary source: HGNC:5360
See related: Ensembl:ENSG00000125968; HPRD:08980; MIM:600349; Vega:OTTHUMG00000032181
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ID; bHLHb24
Summary: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20q11

Sequence :: Chromosome: 20; NC_000020.10 (30193092..30194313)

See ID1 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that IL-3 plays an inhibitory role in osteoclast differentiation by regulating c-Fos and Id1, and also exerts anti-bone erosion effects.
Title: Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-Fos and Id protein expression.
Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
Title: Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
These results demonstrate that Id1-induced beta1-integrin expression in endothelial cells and the function of Id1 in cell migration and tubulogenesis are dependent on p53.
Title: Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin.
Bone morphogenetic proteins and ID1 exerted an anti-apoptotic effect in mesangial cells by inhibition of USF2 transcriptional activity.
Title: ID1 inhibits USF2 and blocks TGF-β-induced apoptosis in mesangial cells.
These results indicate that increased migration of MDA-MB-231 cells following cyclin D1 silencing can be mediated by Id1 and is linked to an increase in EMT markers.
Title: Cyclin D1, Id1 and EMT in breast cancer.
Inhibitor of differentiation 1 expression is correlated to human papillomavirus infection in cervical carcinoma.
Title: Association of inhibitor of differentiation 1 expression with human papillomaviruses infections in cervical carcinoma.
Older muscle contained significantly more transcript for Forkhead Box O 1 (FoxO1, p=0.001), Inhibitor of DNA binding 1 (ID1, p=0.009), and Inhibitor of DNA Binding 3 (ID3, p=0.043) than young muscle.
Title: Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function.
Id1 could be considered as a prognostic predictor for stage III esophageal squamous cell carcinoma patients.
Title: Expression and prognostic relevance of Id1 in stage III esophageal squamous cell carcinoma.
Malignant rhabdoid tumors express many stem cell-associated transcription factors, which may be regulated by the expression of EZH2 and the Id family of proteins.
Title: Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins.
Study revealed that Id1 interacts with LMP1 by binding to the CTAR1 domain of LMP1. N-terminal region of Id1 is required for the interaction with LMP1.
Title: Id1 interacts and stabilizes the Epstein-Barr virus latent membrane protein 1 (LMP1) in nasopharyngeal epithelial cells.

Submit: New GeneRIF Correction See all (135)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates nerve growth factor (NGF)-induced ID1 expression in PC12 neuronal cells through a pathway that involves phosphorylation of Stat5a	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002156.2	NP_003679.1	CASK	BIND	PubMed	CASK interacts with Id1.
NP_851998.1	NP_003679.1	CASK	BIND	PubMed	CASK interacts with Id1'.
P41134	O14936	CASK	HPRD	PubMed
P41134	P19419	ELK1	HPRD	PubMed
P41134	P28324	ELK4	HPRD	PubMed
P41134	Q14469	HES1	HPRD	PubMed
P41134	Q16666	IFI16	HPRD	PubMed
P41134	P13349	MYF5	HPRD	PubMed
P41134	P23409	MYF6	HPRD	PubMed
P41134	P15172	MYOD1	HPRD	PubMed
P41134	P15173	MYOG	HPRD	PubMed
P41134	P55036	PSMD4	HPRD	PubMed
P41134	Q06455	RUNX1T1	HPRD	PubMed
P41134	Q99081	TCF12	HPRD	PubMed
P41134	P15923	TCF3	HPRD	PubMed
P41134	P15884	TCF4	HPRD	PubMed
BioGRID:109623	BioGRID:114141	CASK	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109623	BioGRID:122060	ELSPBP1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109623	BioGRID:108896	GATA4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109623	BioGRID:114089	IKBKG	BioGRID	PubMed	Two-hybrid
BioGRID:109623	BioGRID:110702	MYF5	BioGRID	PubMed	Two-hybrid
BioGRID:109623	BioGRID:110703	MYF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109623	BioGRID:110737	MYOD1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:109623	BioGRID:107864	NKX2-5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109623	BioGRID:122265	SMURF2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:109623	BioGRID:112798	TCF12	BioGRID	PubMed	Two-hybrid
BioGRID:109623	BioGRID:112791	TCF3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109623	BioGRID:112787	TCF4	BioGRID	PubMed	Two-hybrid
BioGRID:109623	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
BMP signaling pathway	IEA Inferred from Electronic Annotation more info
angiogenesis	TAS Traceable Author Statement more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
blood vessel endothelial cell migration	TAS Traceable Author Statement more info	PubMed
blood vessel morphogenesis	TAS Traceable Author Statement more info	PubMed
collagen metabolic process	IEA Inferred from Electronic Annotation more info
endothelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
heart development	IEA Inferred from Electronic Annotation more info
lung morphogenesis	IEA Inferred from Electronic Annotation more info
lung vasculature development	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of DNA binding	IEA Inferred from Electronic Annotation more info
negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription by transcription factor localization	TAS Traceable Author Statement more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
protein destabilization	IEA Inferred from Electronic Annotation more info
regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
response to antibiotic	IEA Inferred from Electronic Annotation more info
transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: DNA-binding protein inhibitor ID-1

Names: DNA-binding protein inhibitor ID-1; inhibitor of differentiation 1; class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029639.1 RefSeqGene

Range

5001..6233

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002165.3 → NP_002156.2 DNA-binding protein inhibitor ID-1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a, also called ID-1H).

Source sequence(s)

AI304595, BC012420, DA839689

Consensus CDS

CCDS13185.1

UniProtKB/Swiss-Prot

P41134

Related

ENSP00000365280, OTTHUMP00000030534, ENST00000376112, OTTHUMT00000078550

Conserved Domains (1) summary

cd00083
Location:68 – 109
Blast Score: 139

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_181353.2 → NP_851998.1 DNA-binding protein inhibitor ID-1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate segment compared to variant 1, that causes a frameshift. The resulting isoform (b, also called ID-1H') is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AI304595, BC012420, BI768231, BM856018

Consensus CDS

CCDS13186.1

UniProtKB/Swiss-Prot

P41134

Related

ENSP00000365273, OTTHUMP00000030535, ENST00000376105, OTTHUMT00000078551

Conserved Domains (1) summary

cd00083
Location:68 – 109
Blast Score: 136

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

30193092..30194313

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

26981787..26983008

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL110115.38	CAC14950.2
		CAI20171.1
genomic	AL117381.32	CAI23029.1
		CAI23030.1
genomic	CH471077.2	EAW76432.1
		EAW76433.1
		EAW76434.1
genomic	U57645.1	AAC13882.1
		AAC13883.1
mRNA	AI304595.1	None
mRNA	AK291152.1	BAF83841.1
mRNA	AK313786.1	None
mRNA	BC000613.2	AAH00613.1
mRNA	BC012420.1	AAH12420.1
mRNA	BG546814.1	None
mRNA	BI768231.1	None
mRNA	BM856018.1	None
mRNA	BT007443.1	AAP36111.1
mRNA	D13889.1	BAA02988.1
mRNA	D13890.1	BAA02989.1
mRNA	DA839689.1	None
mRNA	S78825.1	AAB35038.1
mRNA	S78986.1	AAB35037.1
mRNA	X77956.1	CAA54920.1
other-genetic	DQ891293.2	ABM82219.1
other-genetic	DQ893342.2	ABM84268.1
other-genetic	DQ894477.2	ABM85403.1
other-genetic	DQ896657.2	ABM87656.1
other-genetic	EU176458.1	ABW03909.1
other-genetic	EU176468.1	ABW03919.1
other-genetic	EU176808.1	ABW03609.1