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    Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C [ Drosophila melanogaster ]

    Gene ID: 33968, updated on 10-May-2012
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    Summary

    Official Symbol
    Hrb27Cprovided by Flybase
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein at 27Cprovided by Flybase
    Primary source
    FLYBASE:FBgn0004838
    Locus tag
    Dmel_CG10377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10280; CG10377; Dmel\CG10377; hnRNP27C; hnRNP48; Hrb27-C; hrb27c; hrb27C; Hrb27c; Hrb48; hrp48; Hrp48; HRP48; l(2)02647; l(2)10280; l(2)2647; linha; Ov5; p50; Rbp7; rrm7; RRM7
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    Genomic context

    Location :
    27C4-27C4
    Sequence :
    Chromosome: 2L; NT_033779.4 (6920693..6928678)
    See Hrb27C in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CG32829 gene product from transcript CG32829-RA Neighboring gene CG10203 gene product from transcript CG10203-RA Neighboring gene CG10206 gene product from transcript CG10206-RA Neighboring gene CG43232 gene product from transcript CG43232-RA Neighboring gene CG18304 gene product from transcript CG18304-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Drosophila histone locus bodies form by hierarchical recruitment of components. White AE, et al. J Cell Biol, 2011 May 16. PMID 21576393.
    3. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518.
    4. TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. Ritson GP, et al. J Neurosci, 2010 Jun 2. PMID 20519548.
    5. poly is required for nurse-cell chromosome dispersal and oocyte polarity in Drosophila. Klusza S, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473032.

    See all (77) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development
      Title: Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development.
    2. Three proteins (DDP1, Hrp48, and poly(A)-binding protein) are components of the HDE-binding complex and function in translational enhancement
      Title: A multiprotein complex that mediates translational enhancement in Drosophila.
    3. Data show that Squid (Sqd) interacts with Hrb27C, and that Ovarian tumor (Otu) cooperates with Hrb27C and Sqd in the oocyte to mediate proper gurken (grk) localization.
      Title: Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_476869.1 NM_057220.3 grk    BIND  PubMed grk mRNA interacts with Hrb27C. 
    NP_476869.1 osk    BIND  PubMed An unspecified transcript variant of osk mRNA interacts with Hrb27C. 
    NP_476869.1 otu    BIND  PubMed An unspecified isoform of Otu interacts with Hrb27C. 
    NP_476869.1 NP_731826.1 sqd    BIND  PubMed Sqd interacts with Hrb27C. 
    BioGRID:60119 BioGRID:67510 C15    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:59250 CG14204    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:63701 CG2199    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:77496 CG33056    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:60119 BioGRID:58133 CG4617    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:60813 CG9008    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:60119 BioGRID:66690 CtBP    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:66283 Fps85D    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:534312 His1:CG33825    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:60119 BioGRID:61171 Lim3    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:67679 Rassf    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:68122 Rb97D    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:67078 Ubx    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:60119 BioGRID:70938 fs(1)K10    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:57556 l(1)sc    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:60119 BioGRID:60786 loqs    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:63870 prominin-like    BioGRID  PubMed Two-hybrid 
    BioGRID:60119 BioGRID:66748 sqd    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:60119 BioGRID:64594 tna    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Hrb27C gene: The Hrb27C gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

    Pathways from BioSystems

    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mRNA 3'-UTR binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mRNA 5'-UTR binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    mRNA 5'-UTR binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mRNA binding NAS
    Non-traceable Author Statement
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lateral inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		  
    mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of oskar mRNA translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of nuclear mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    ribonucleoprotein complex NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG10377 gene product from transcript CG10377-RH
    Names
    CG10377-PA
    CG10377-PB
    CG10377-PC
    CG10377-PD
    CG10377-PE
    CG10377-PF
    CG10377-PG
    CG10377-PH
    Hrb27C-PA
    Hrb27C-PB
    Hrb27C-PC
    Hrb27C-PD
    Hrb27C-PE
    Hrb27C-PF
    Hrb27C-PG
    Hrb27C-PH
    RNA-binding protein 7
    heterogeneous nuclear ribonucleoprotein
    heterogeneous nuclear ribonucleoprotein at 27C
    linha
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      6920693..6928678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258990.1 → NP_001245919.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform H [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_057521.5 → NP_476869.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHA4
      UniProtKB/Swiss-Prot
      P48809
      Related
      FBpp0078974
      Conserved Domains (1) summary
      cd00590
      Location:8 – 77
      Blast Score: 191
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    3. NM_001169426.1 → NP_001162897.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHA4
      UniProtKB/Swiss-Prot
      P48809
      Related
      FBpp0290617, FBtr0301403
      Conserved Domains (1) summary
      cd00590
      Location:8 – 77
      Blast Score: 191
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    4. NM_001258989.1 → NP_001245918.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform G [Drosophila melanogaster]

      Status: REVIEWED

    5. NM_001258988.1 → NP_001245917.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform F [Drosophila melanogaster]

      Status: REVIEWED

    6. NM_164721.2 → NP_723229.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHA4
      UniProtKB/Swiss-Prot
      P48809
      Related
      FBpp0078975, FBtr0079347
      Conserved Domains (1) summary
      cd00590
      Location:8 – 77
      Blast Score: 191
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    7. NM_001169427.1 → NP_001162898.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHA4
      UniProtKB/Swiss-Prot
      P48809
      Related
      FBpp0290618, FBtr0301404
      Conserved Domains (1) summary
      cd00590
      Location:8 – 77
      Blast Score: 191
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    8. NM_164720.3 → NP_723228.1  heterogeneous nuclear ribonucleoprotein at 27C, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHA4
      UniProtKB/Swiss-Prot
      P48809
      Related
      FBpp0078976
      Conserved Domains (1) summary
      cd00590
      Location:8 – 77
      Blast Score: 191
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014134.5 AFH03593.1
    genomic HB886987.1 CBF67650.1
    mRNA AY069699.1 AAL39844.1
    genomic AE014134.5 ACZ94189.1
    genomic AE014134.5 ACZ94188.1
    genomic HC944396.1 CBU92524.1
    mRNA DQ062784.1 AAY56657.1
    mRNA AY128430.1 AAM75023.1
    genomic AE014134.5 AAF52457.1
    genomic AE014134.5 AFH03592.1
    genomic AE014134.5 AAF52456.1
    genomic AE014134.5 AFH03591.1
    genomic AE014134.5 AAN10605.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48809.2 GenPept
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    Additional Links

    Gene LinkOut

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