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Rca1 Regulator of cyclin A1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33959, updated on 4-Apr-2024

Summary

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Official Symbol
Rca1provided by FlyBase
Official Full Name
Regulator of cyclin A1provided by FlyBase
Primary source
FLYBASE:FBgn0017551
Locus tag
Dmel_CG10800
See related
AllianceGenome:FB:FBgn0017551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
152549_at; CG10800; CLD4; Dmel\CG10800; Emi1; FBXO5; l(2)03300; P3300; rca1; RCA1; S(rux)2A
Summary
Involved in G1/S transition of mitotic cell cycle and negative regulation of ubiquitin protein ligase activity. Located in nucleus. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; and presumptive embryonic/larval nervous system. Orthologous to human FBXO43 (F-box protein 43) and FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
27C1-27C1; 2-23 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6852315..6853866)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6852315..6853866)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44081 Neighboring gene senseless-2 Neighboring gene lethal (2) k09022 Neighboring gene Na[+]/H[+] hydrogen antiporter 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of sleep by cyclin A and its regulator. Rogulja D, et al. Science, 2012 Mar 30. PMID 22461610, Free PMC Article
  2. An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila. Boukhatmi H, et al. Development, 2014 Oct. PMID 25209244
  3. Requirements of cyclin a for mitosis are independent of its subcellular localization. Dienemann A, et al. Curr Biol, 2004 Jun 22. PMID 15203007
  4. Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation. Erhardt S, et al. J Cell Biol, 2008 Dec 1. PMID 19047461, Free PMC Article
  5. Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. Araki M, et al. EMBO J, 2003 Nov 17. PMID 14609957, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin ligase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in negative regulation of meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
regulator of cyclin A1
Names
CG10800-PA
Rca1-PA
regulator of cyclin A
regulator of cyclin A 1
suppressor of rux 2A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6852315..6853866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057866.3 → NP_477214.1  regulator of cyclin A1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91666, Q9VM76
    Related
    FBpp0078970
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91666 P91666
Q9VM76 Q9VM76

Gene LinkOut

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