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    Rca1 Regulator of cyclin A1 [ Drosophila melanogaster ]

    Gene ID: 33959, updated on 10-May-2012
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    Summary

    Official Symbol
    Rca1provided by Flybase
    Official Full Name
    Regulator of cyclin A1provided by Flybase
    Primary source
    FLYBASE:FBgn0017551
    Locus tag
    Dmel_CG10800
    Gene type
    protein coding
    RNA name
    regulator of cyclin A1
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    152549_at; CG10800; CLD4; Dmel\CG10800; Emi1; l(2)03300; P3300; rca1; RCA1; S(rux)2A
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    Genomic context

    Location :
    27C1-27C1
    Sequence :
    Chromosome: 2L; NT_033779.4 (6852324..6853876)
    See Rca1 in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG17375 gene product from transcript CG17375-RB Neighboring gene senseless-2 Neighboring gene lethal (2) k09022 Neighboring gene Na[+]/H[+] hydrogen antiporter 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Control of sleep by cyclin A and its regulator. Rogulja D, et al. Science, 2012 Mar 30. PMID 22461610.
    2. A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. Buttitta LA, et al. J Cell Biol, 2010 Jun 14. PMID 20548101.
    3. A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. Liu YH, et al. Dev Cell, 2009 Feb. PMID 19217429.
    4. The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. Rogers GC, et al. J Cell Biol, 2009 Jan 26. PMID 19171756.
    5. Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation. Erhardt S, et al. J Cell Biol, 2008 Dec 1. PMID 19047461.

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. findings show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep
      Title: Control of sleep by cyclin A and its regulator.
    2. We propose that Rca1 acts as an F-box protein in an as yet uncharacterized SCF complex, which promotes S-phase entry.
      Title: Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:60110 BioGRID:57905 CG11444    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:60433 CG13133    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:67725 CG13822    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:64580 CG14151    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:68440 CG15529    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:64487 CG3448    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:67401 CG4335    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:64701 CycA    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:60110 BioGRID:60939 CycE    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:60110 BioGRID:62784 GstE10    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:59253 RpS10b    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:59696 Syt1    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:60390 Taf11    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:70919 betaggt-II    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:65692 olf413    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:69987 rap    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:60110 BioGRID:58031 rux    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:60110 BioGRID:57584 skpA    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:62080 skpB    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:63314 skpF    BioGRID  PubMed Two-hybrid 
    BioGRID:60110 BioGRID:64781 ver    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		  
    G2 phase of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		  
    compound eye morphogenesis NAS
    Non-traceable Author Statement
    more info
    		  
    eye-antennal disc morphogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    lateral inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of mitotic anaphase-promoting complex activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of protein catabolic process NAS
    Non-traceable Author Statement
    more info
    		  
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of mitosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG10800 gene product from transcript CG10800-RA
    Names
    CG10800-PA
    Rca1-PA
    regulator of cyclin A
    regulator of cyclin A 1
    regulator of cyclin A1
    suppressor of rux 2A
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      6852324..6853876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057866.2 → NP_477214.1  regulator of cyclin A1 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM76
      Related
      FBpp0078970, FBtr0079342
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY058372.1 AAL13601.1
    genomic AE014134.5 AAF52448.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM76.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content