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    cup [ Drosophila melanogaster ]

    Gene ID: 33934, updated on 10-May-2012
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    Summary

    Official Symbol
    cupprovided by Flybase
    Primary source
    FLYBASE:FBgn0000392
    Locus tag
    Dmel_CG11181
    Gene type
    protein coding
    RNA name
    cup
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11181; Cup; CUP; Dmel\CG11181; fs(1)cup; fs(2)cup; i239
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    Genomic context

    Location :
    26F6-26F7; 2-23 cM
    Sequence :
    Chromosome: 2L; NT_033779.4 (6663965..6674790)
    See cup in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG11070 gene product from transcript CG11070-RA Neighboring gene CG13771 gene product from transcript CG13771-RA Neighboring gene Galactose-1-phosphate uridylyltransferase Neighboring gene Serpin 27A Neighboring gene CG34310 gene product from transcript CG34310-RA Neighboring gene cortex Neighboring gene CG11329 gene product from transcript CG11329-RA Neighboring gene Na[+]/H[+] hydrogen exchanger 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CUP promotes deadenylation and inhibits decapping of mRNA targets. Igreja C, et al. Genes Dev, 2011 Sep 15. PMID 21937713.
    2. Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. Jeske M, et al. EMBO J, 2011 Jan 5. PMID 21081899.
    3. Drosophila ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts. Tastan OY, et al. Development, 2010 Oct. PMID 20724451.
    4. A Drosophila melanogaster model of classic galactosemia. Kushner RF, et al. Dis Model Mech, 2010 Sep-Oct. PMID 20519569.
    5. Intracellular compartmentation of CTP synthase in Drosophila. Liu JL. J Genet Genomics, 2010 May. PMID 20513629.

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. n addition to inducing translational repression, CUP maintains mRNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation
      Title: CUP promotes deadenylation and inhibits decapping of mRNA targets.
    2. This review describes Cup as a multifunctional protein directly and/or indirectly affecting the activity of different mRNAs and proteins by diverse molecular mechanisms in order to achieve a broad range of biological functions.
      Title: A cup full of functions.
    3. Hsp90 interacts in vitro with the translational repressor Cup.
      Title: The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis.
    4. Transcription of comets and cups occurs just before protamines can be detected in spermatid nuclei.
      Title: Comet and cup genes in Drosophila spermatogenesis: the first demonstration of post-meiotic transcription.
    5. Sqd, cup, and PABP55B function together to regulate gurken translation.
      Title: Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.
    6. an important downstream effector of a Drosophila forkhead transcription factor phenotype, and regulation of translation by eIF4E is vital during environmental stress
      Title: Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.
    7. cup, nup154 double mutants exhibit much stronger oogenesis defects than single mutants
      Title: nup154 genetically interacts with cup and plays a cell-type-specific function during Drosophila melanogaster egg-chamber development.
    8. Cup is required to repress precocious osk translation. Cup binds the 5'-cap binding translation initiation factor eIF4E through a sequence conserved among eIF4E binding proteins.
      Title: Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.
    9. Cup is a translational repressor of oskar that is required to assemble the oskar mRNA localization machinery. We propose that Cup coordinates localization with translation
      Title: Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz.
    10. Cup is an eIF4E-binding protein that functions in smg-mediated translational repression.
      Title: Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.
    Submit: New GeneRIF Correction See all (11)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_523493.2 NP_731924.1 stumps    BIND  PubMed Dof interacts with Cup. 
    BioGRID:60088 BioGRID:67789 CG10694    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:68045 CG14540    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:58000 CG15771    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:57754 CG2865    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:78204 CG40045    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:65515 CG5274    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:68415 CG7911    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:61348 CG8677    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:78241 Cht3    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:66904 Hsc70-4    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:61801 Pdk    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:57590 RpL22    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:66481 RpL3    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:61093 RpS26    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:58532 Tango10    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:58951 Traf-like    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:69740 eIF-4E    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:60088 BioGRID:57622 eIF4E-7    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:61396 gus    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:60455 me31B    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:58905 mmd    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:67295 nos    BioGRID  PubMed Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:60088 BioGRID:58248 otu    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:60088 BioGRID:71089 rin    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:64438 smg    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:60088 BioGRID:65697 srpk79D    BioGRID  PubMed Two-hybrid 
    BioGRID:60088 BioGRID:61114 tos    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    translation regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    centrosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		  
    chromosome organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    female meiosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    meiotic chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of oskar mRNA translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of oskar mRNA translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of translation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ovarian follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic mRNA processing body IDA
    Inferred from Direct Assay
    more info
    		  
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG11181 gene product from transcript CG11181-RB
    Names
    CG11181-PB
    cup
    cup-PB
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      6663965..6674790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078769.2 → NP_523493.3  cup [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMA3
      Related
      FBpp0288761, FBtr0290322
      Conserved Domains (1) summary
      pfam10477
      Location:546 – 626
      Blast Score: 130
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014134.5 AAF52418.3
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMA3.3 GenPept
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    Additional Links

    Gene LinkOut

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