Format

Send to:

Choose Destination

HCAR2 hydroxycarboxylic acid receptor 2 [ Homo sapiens (human) ]

Gene ID: 338442, updated on 7-May-2016
Official Symbol
HCAR2provided by HGNC
Official Full Name
hydroxycarboxylic acid receptor 2provided by HGNC
Primary source
HGNC:HGNC:24827
See related
Ensembl:ENSG00000182782 HPRD:16453; MIM:609163; Vega:OTTHUMG00000162722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A
Orthologs
Location:
12q24.31
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (122701293..122703357, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123185840..123194392, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene kinetochore associated 1 Neighboring gene uncharacterized LOC105370037 Neighboring gene hydroxycarboxylic acid receptor 3 Neighboring gene hydroxycarboxylic acid receptor 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Hydroxycarboxylic acid-binding receptors, organism-specific biosystem (from REACTOME)
    Hydroxycarboxylic acid-binding receptors, organism-specific biosystemThe G-protein-coupled receptors Hydroxy-carboxylic acid receptor 1 (HCAR1, GPR81), HCAR2 (GPR109A), and HCAR3 (GPR109B) have significant sequence homology and are encoded by clustered genes. Their en...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nicotinic acid receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of adiponectin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neutrophil apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
hydroxycarboxylic acid receptor 2
Names
G protein-coupled receptor 109A
G protein-coupled receptor HM74a
G-protein coupled receptor 109A
G-protein coupled receptor HM74A
hydroxy-carboxylic acid receptor 2
niacin receptor 1
nicotinic acid receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177551.3NP_808219.1  hydroxycarboxylic acid receptor 2

    See identical proteins and their annotated locations for NP_808219.1

    Status: VALIDATED

    Source sequence(s)
    AL572062, AL698846, BC027965, BC056419, CD364466
    Consensus CDS
    CCDS9235.1
    UniProtKB/Swiss-Prot
    Q8TDS4
    Related
    ENSP00000375066, OTTHUMP00000222584, ENST00000328880, OTTHUMT00000370202
    Conserved Domains (1) summary
    pfam00001
    Location:50294
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    122701293..122703357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    123154148..123156212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)