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IFNE interferon, epsilon [ Homo sapiens (human) ]

Gene ID: 338376, updated on 8-May-2016
Official Symbol
IFNEprovided by HGNC
Official Full Name
interferon, epsilonprovided by HGNC
Primary source
HGNC:HGNC:18163
See related
Ensembl:ENSG00000184995 HPRD:17132; MIM:615223; Vega:OTTHUMG00000019672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFN-E; IFNE1; IFNT1; INFE1; PRO655
Orthologs
Location:
9p21.3
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (21480839..21482313, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21480838..21482312, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interferon, alpha 1 Neighboring gene MIR31 host gene Neighboring gene interferon, omega 1 pseudogene 19 Neighboring gene microRNA 31 Neighboring gene KH-type splicing regulatory protein pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
THOC5: a novel gene involved in HDL-cholesterol metabolism.
NHGRI GWA Catalog
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC119018, MGC119020

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
type I interferon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
natural killer cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
 
response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
interferon epsilon
Names
IFN-epsilon
interferon epsilon 1
interferon epsilon-1
interferon tau-1
interferon-epsilon

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176891.4NP_795372.1  interferon epsilon precursor

    See identical proteins and their annotated locations for NP_795372.1

    Status: VALIDATED

    Source sequence(s)
    AL353732, AY358570
    Consensus CDS
    CCDS34997.1
    UniProtKB/Swiss-Prot
    Q86WN2
    Related
    ENSP00000418018, OTTHUMP00000215910, ENST00000448696, OTTHUMT00000051901
    Conserved Domains (1) summary
    cl00092
    Location:29188
    IFab; Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    21480839..21482313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    21480654..21482129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)