Ifnl3 interferon lambda 3 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ifnl3provided by MGI
Official Full Name: interferon lambda 3provided by MGI
Primary source: MGI:2450574
See related: Ensembl:ENSMUSG00000060747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il28; IFL-1; Il28b; IL-28B; INF-alpha; INF-lambda

Genomic context

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Location :: 7 A3; 7

Sequence :: Chromosome: 7; NC_000073.6 (28522836..28524322)

See Ifnl3 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c(+) DC function in experimental allergic asthma.
Title: IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease.
IFN-lambda is involved in development and maintenance of oral tolerance in the intestines of mice.
Title: Interferon-λ mediates oral tolerance and inhibits antigen-specific, T-helper 2 cell-mediated inflammation in mouse intestine.
IFN-alpha, IFN-beta, and IFN-gamma were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta and IFN-gamma were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection
Title: Interferon-gamma, macrophages, and virus spread after HSV-1 injection.
the duration of IFNlambda signaling to JAK/STAT is different from that of IFNalpha
Title: IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity.
intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR-/- mice
Title: Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo.
IFN-lambda contributes to the control of viral infections in epithelial cells of both respiratory and gastrointestinal tracts.
Title: Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.
IL-28B can induce 100% protection from mortality after a lethal influenza challenge
Title: Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity.
IFN-lambda contributes to inborn resistance against viral pathogens infecting the lung but not the liver
Title: Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses.
Type III interferon/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll-like receptors, largely mediated by inducing an antiviral state in epithelial cells.
Title: An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity.
IL-28A emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury
Title: IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet.

Submit: New GeneRIF Correction See all (11)

Pathways from BioSystems

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Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...

General gene information

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Homology

Homologs of the Ifnl3 gene: The Ifnl3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
receptor binding	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
defense response to virus	IEA Inferred from Electronic Annotation more info
innate immune response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon lambda-3

Names: interferon lambda-3; IFN-lambda-3; interleukin 28; interleukin 28B; interleukin-28B; interferon alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177396.1 → NP_796370.1 interferon lambda-3 precursor

Status: PROVISIONAL

Source sequence(s)

AY184375

Consensus CDS

CCDS21047.1

UniProtKB/Swiss-Prot

Q8CGK6

Related

ENSMUSP00000077473, ENSMUST00000078364

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

28522836..28524322

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

23085567..23087055

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01060137.1 (137021..138509)	None
genomic	AC136456.3 (63673..65159)	None
mRNA	AY184375.1	AAN86128.1	C57BL
mRNA	AY869696.1	AAX58715.1	129/Sv
other-genetic	BC140273.1	AAI40274.1
other-genetic	BC141644.1	AAI41645.1