Lam Lamin [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Lamprovided by Flybase
Official Full Name: Laminprovided by Flybase
Primary source: FLYBASE:FBgn0002525
Locus tag: Dmel_CG6944
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2459; 74/76; CG6944; D5; Dm; Dm(0); Dm0; Dm1; Dm2; Dmel\CG6944; DmLamin; Dmo; DmO; Dm[[0]]; Dm[[1]]; Dm[[2]]; Dm[[mit]]; Dm[[o]]; DM[[O]]; jf27; l(2)04643; l(2)25Ec; l(2)gdh-7; l(2)gdh7; l(2)jf27; lam; LAM; Lam Dm[[0]]; Lam(Dm0); lamDm0; lamDm[[0]]; LamDm[[0]]; lamin; lamin Dm0; lamin Dm[[0]]; Lamin Dm[[0]]; Lam[[Dm0]]; misg; nlam

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Genomic context

Location :: 25E6-25E6

Sequence :: Chromosome: 2L; NT_033779.4 (5542544..5546642)

See Lam in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA).
Title: Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis.
Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina.
Title: Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane.
Lamin mutation is associated with neuromuscular defects and premature aging.
Title: Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies.
analysis of Drosophila and human A-type lamins
Title: A comparative study of Drosophila and human A-type lamins.
prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B envelope.
Title: Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope.
developmental disorders caused by lesions in the B-type lamins and interacting proteins
Title: The B-type lamin is required for somatic repression of testis-specific gene clusters.
Induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies.
Title: The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.
Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis.
Title: The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells.
The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila.
Title: The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila.
Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal
Title: Specific and conserved sequences in D. melanogaster and C. elegans lamins and histone H2A mediate the attachment of lamins to chromosomes.

Submit: New GeneRIF Correction See all (11)

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:59950	BioGRID:59415	CG17599	BioGRID	PubMed	Two-hybrid
BioGRID:59950	BioGRID:67579	CG7069	BioGRID	PubMed	Two-hybrid
BioGRID:59950	BioGRID:60196	CG7196	BioGRID	PubMed	Two-hybrid
BioGRID:59950	BioGRID:68262	CG9986	BioGRID	PubMed	Two-hybrid
BioGRID:59950	BioGRID:67217	Dlc90F	BioGRID	PubMed	Affinity Capture-MS
BioGRID:59950	BioGRID:68851	Mkrn1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:59950	BioGRID:62771	Ote	BioGRID	PubMed	Affinity Capture-MS; Two-hybrid
BioGRID:59950	BioGRID:60430	Pen	BioGRID	PubMed	Two-hybrid
BioGRID:59950	BioGRID:61322	RPA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:59950	BioGRID:66153	RpA-70	BioGRID	PubMed	Affinity Capture-MS
BioGRID:59950	BioGRID:66321	bocksbeutel	BioGRID	PubMed	Affinity Capture-MS
BioGRID:59950	BioGRID:67796	sec10	BioGRID	PubMed	Two-hybrid
BioGRID:59950	BioGRID:58984	spheroide	BioGRID	PubMed	Affinity Capture-MS

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General gene information

Markers

Dm0092 (e-PCR)
- UniSTS:17157

Pathways from BioSystems

Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
Apoptotic cleavage of cellular proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic execution phase, organism-specific biosystem (from REACTOME)
Apoptotic execution phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Breakdown of the nuclear lamina, organism-specific biosystem (from REACTOME)
Breakdown of the nuclear lamina, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
centrosome organization	IMP Inferred from Mutant Phenotype more info
chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
chromatin silencing	IMP Inferred from Mutant Phenotype more info	PubMed
compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
lateral inhibition	IMP Inferred from Mutant Phenotype more info
mitotic nuclear envelope reassembly	IDA Inferred from Direct Assay more info	PubMed
mitotic nuclear envelope reassembly	ISS Inferred from Sequence or Structural Similarity more info
nuclear envelope organization	IMP Inferred from Mutant Phenotype more info	PubMed
nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info
lamin filament	ISS Inferred from Sequence or Structural Similarity more info
lamin filament	NAS Non-traceable Author Statement more info
lamin filament	TAS Traceable Author Statement more info	PubMed
lipid particle	IDA Inferred from Direct Assay more info	PubMed
microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
mitotic spindle	IDA Inferred from Direct Assay more info
nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
nuclear lamina	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG6944 gene product from transcript CG6944-RA

Names: B-type lamin; CG6944-PA; CG6944-PB; CG6944-PC; Lam-PA; Lam-PB; Lam-PC; Lamin-B; LaminDm; LaminDm0; alpha-Lamin; intermediate filament-like lamina; lamin; lamin A; lamin B; lamin D; lamin D[[0]]; lamin D[[m]]0; lamin D[[o]]; lamin Dm0; lamin Dm[[0]]; lamin Dmo; lethal(2)25Ec; misguided; misrouted; n-lamin; nuclear lamin

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

5542544..5546642

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057268.4 → NP_476616.1 lamin, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P08928

Related

FBpp0078733

Conserved Domains (2) summary

pfam00038
Location:159 – 409
Blast Score: 384

Filament; Intermediate filament protein

pfam00932
Location:465 – 575
Blast Score: 189

LTD; Lamin Tail Domain
NM_001258964.1 → NP_001245893.1 lamin, isoform C [Drosophila melanogaster]

Status: REVIEWED
NM_001258963.1 → NP_001245892.1 lamin, isoform B [Drosophila melanogaster]

Status: REVIEWED