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lnpk lunapark, ER junction formation factor [ Danio rerio (zebrafish) ]

Gene ID: 337509, updated on 27-Mar-2024

Summary

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Official Symbol
lnpkprovided by ZNC
Official Full Name
lunapark, ER junction formation factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9455
See related
Ensembl:ENSDARG00000006639 AllianceGenome:ZFIN:ZDB-GENE-030131-9455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lnpb; lnpkb; fj80c12; wu:fj80c12
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Predicted to be located in endoplasmic reticulum tubular network membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum tubular network. Orthologous to human LNPK (lunapark, ER junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (10838635..10863663, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (10603211..10628244, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, alpha 1 (muscle) Neighboring gene ATP synthase membrane subunit c locus 3b Neighboring gene uncharacterized LOC108190371 Neighboring gene microRNA 10d Neighboring gene metaxin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish hoxDb cluster has been reduced to a single microRNA. Woltering JM, et al. Nat Genet, 2006 Jun. PMID 16736008
  2. Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI. Mackay EW, et al. Development, 2015 Mar 15. PMID 25758222
  3. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Ahn D, et al. Dev Biol, 2008 Oct 1. PMID 18638469
  4. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Hogl S, et al. Proteomics, 2013 May. PMID 23457027
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endoplasmic reticulum tubular network organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endoplasmic reticulum tubular network organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum tubular network membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endoplasmic reticulum junction formation protein lunapark-B; protein lunapark-B
Names
ER junction formation factor lunapark
limb and neural patterns b
lunapark-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159912.1 → NP_001153384.1  endoplasmic reticulum junction formation protein lunapark-B

    Status: VALIDATED

    Source sequence(s)
    BX546447, CT573297
    UniProtKB/Swiss-Prot
    Q6PFM4
    UniProtKB/TrEMBL
    A0A8M1NRF5, F1QDW0
    Related
    ENSDARP00000123589.1, ENSDART00000133893.3
    Conserved Domains (2) summary
    pfam10058
    Location:257 → 305
    zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
    pfam10631
    Location:155 → 246
    DUF2477; Protein of unknown function (DUF2477)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    10838635..10863663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165764.4 → XP_005165821.1  protein lunapark-B isoform X1

    See identical proteins and their annotated locations for XP_005165821.1

    UniProtKB/Swiss-Prot
    Q6PFM4
    UniProtKB/TrEMBL
    A0A0R4IYI7, A0A8M2BD13
    Conserved Domains (2) summary
    pfam10058
    Location:257 → 305
    zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
    pfam10631
    Location:155 → 246
    DUF2477; Protein of unknown function (DUF2477)

  2. XM_005165762.4 → XP_005165819.1  protein lunapark-B isoform X1

    See identical proteins and their annotated locations for XP_005165819.1

    UniProtKB/Swiss-Prot
    Q6PFM4
    UniProtKB/TrEMBL
    A0A0R4IYI7, A0A8M2BD13
    Conserved Domains (2) summary
    pfam10058
    Location:257 → 305
    zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
    pfam10631
    Location:155 → 246
    DUF2477; Protein of unknown function (DUF2477)

  3. XM_005165763.4 → XP_005165820.1  protein lunapark-B isoform X1

    See identical proteins and their annotated locations for XP_005165820.1

    UniProtKB/Swiss-Prot
    Q6PFM4
    UniProtKB/TrEMBL
    A0A0R4IYI7, A0A8M2BD13
    Related
    ENSDARP00000141011.1, ENSDART00000164342.3
    Conserved Domains (2) summary
    pfam10058
    Location:257 → 305
    zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
    pfam10631
    Location:155 → 246
    DUF2477; Protein of unknown function (DUF2477)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFM4.2 GenPept UniProtKB/Swiss-Prot:Q6PFM4

Gene LinkOut

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