RpL40 Ribosomal protein L40 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: RpL40provided by Flybase
Official Full Name: Ribosomal protein L40provided by Flybase
Primary source: FLYBASE:FBgn0003941
Locus tag: Dmel_CG2960
Gene type: protein coding
RNA name: ribosomal protein L40
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE10554; CEP52; CG2960; Dmel\CG2960; Dub52; DUb52; M(2)24D; Rpl40; Ub52; Ubi-f; Ubi-f52; Ubiq

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Genomic context

Location :: 24E1-24E1

Sequence :: Chromosome: 2L; NT_033779.4 (4227642..4228563)

See RpL40 in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:59826	BioGRID:67789	CG10694	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:64807	CG11009	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:67966	CG11878	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:72610	CG14104	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:60369	CG17855	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:67487	CG3353	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:58064	CG3847	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:58345	CG42797	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:67998	CG5111	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:62611	CG6805	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:66522	CG6808	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:77555	LpR1	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:66992	Sap47	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:68312	dgt6	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:61072	elfless	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:65303	star1	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:68531	stops	BioGRID	PubMed	Two-hybrid
BioGRID:59826	BioGRID:66338	trbd	BioGRID	PubMed	Two-hybrid

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General gene information

Markers

TEI0510 (e-PCR), detects polymorphism
- UniSTS:535696

Pathways from BioSystems

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem (from REACTOME)
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem (from REACTOME)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
Cap-dependent Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Circadian Clock, organism-specific biosystem (from REACTOME)
Circadian Clock, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytoplasmic Ribosomal Proteins, organism-specific biosystem (from WikiPathways)
Cytoplasmic Ribosomal Proteins, organism-specific biosystem
Cytoplasmic Ribosomal Proteins
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication, organism-specific biosystem (from WikiPathways)
DNA Replication, organism-specific biosystemDNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original ...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR downregulation, organism-specific biosystem (from REACTOME)
EGFR downregulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Termination, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Termination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fanconi Anemia pathway, organism-specific biosystem (from REACTOME)
Fanconi Anemia pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
G1/S DNA Damage Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NF-kB is activated and signals survival, organism-specific biosystem (from REACTOME)
NF-kB is activated and signals survival, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide chain elongation, organism-specific biosystem (from REACTOME)
Peptide chain elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Apoptosis, organism-specific biosystem (from REACTOME)
Regulation of Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of activated PAK-2p34 by proteasome mediated degradation, organism-specific biosystem (from REACTOME)
Regulation of activated PAK-2p34 by proteasome mediated degradation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ribosome, organism-specific biosystem (from KEGG)
Ribosome, organism-specific biosystem
Ribosome
Ribosome, conserved biosystem (from KEGG)
Ribosome, conserved biosystem
Ribosome
Ribosome, eukaryotes, organism-specific biosystem (from KEGG)
Ribosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; Ribosome
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH, organism-specific biosystem (from REACTOME)
Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
Signaling by NOTCH1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Wnt, organism-specific biosystem (from REACTOME)
Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystem (from REACTOME)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystem (from REACTOME)
Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystem (from REACTOME)
Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Independent DNA Damage Response, organism-specific biosystem (from REACTOME)
p53-Independent DNA Damage Response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Independent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
p53-Independent G1/S DNA damage checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
p75 NTR receptor-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p75NTR signals via NF-kB, organism-specific biosystem (from REACTOME)
p75NTR signals via NF-kB, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info
structural constituent of ribosome	NAS Non-traceable Author Statement more info
structural constituent of ribosome	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
protein modification process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
translation	ISS Inferred from Sequence or Structural Similarity more info
translation	TAS Traceable Author Statement more info	PubMed
ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
cytosolic large ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
lipid particle	IDA Inferred from Direct Assay more info
microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
ribosome	NAS Non-traceable Author Statement more info

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General protein information

Preferred Names: CG2960 gene product from transcript CG2960-RA

Names: CG2960-PA; RpL40-PA; ribosomal protein L40; ubiquitin; ubiquitin 52-AA extension protein; ubiquitin fusion 52

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

4227642..4228563

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057428.3 → NP_476776.1 ribosomal protein L40 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P18101

UniProtKB/TrEMBL

Q7JYK1

Related

FBpp0077159, FBtr0077470

Conserved Domains (3) summary

cd01803
Location:1 – 76
Blast Score: 401

Ubiquitin; Ubiquitin

cl00671
Location:77 – 128
Blast Score: 221

Ribosomal_L40e; Ribosomal L40e family

smart00213
Location:1 – 72
Blast Score: 280

UBQ; Ubiquitin homologues