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    jun jun proto-oncogene [ Danio rerio (zebrafish) ]

    Gene ID: 335916, updated on 19-May-2013
    Official Symbol
    junprovided by ZNC
    Official Full Name
    jun proto-oncogeneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7859
    Locus tag
    DKEY-86E18.3
    See related
    Ensembl:ENSDARG00000043531; Vega:OTTDARG00000009040
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    c-Jun; fj36h07; zgc:65863; wu:fj36h07
    Location :
    chromosome: 20
    Sequence :
    Chromosome: 20; NC_007131.5 (15558608..15560467)
    See jun in MapViewer

    Chromosome 20 - NC_007131.5Genomic Context describing neighboring genes Neighboring gene phosphatidic acid phosphatase type 2 domain containing 2 Neighboring gene peroxiredoxin 6 Neighboring gene si:dkey-86e18.2 Neighboring gene si:dkey-86e18.1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Eaf1 and Eaf2 negatively regulate canonical Wnt/β-catenin signaling. Liu JX, et al. Development, 2013 Mar. PMID 23364330.
    2. Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro. Tse HY, et al. J Ethnopharmacol, 2012 Jan 31. PMID 22138660.
    3. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Li S, et al. Mol Biosyst, 2011 Nov. PMID 21909574.
    4. Rapid screening of innate immune gene expression in zebrafish using reverse transcription - multiplex ligation-dependent probe amplification. Rotman J, et al. BMC Res Notes, 2011 Jun 15. PMID 21676242.
    5. Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. Veth KN, et al. PLoS Genet, 2011 Feb. PMID 21379331.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CPEB-1 control of c-Jun mRNA translation regulates GH gene expression and resulting downstream signaling events (e.g., synaptic plasticity) in the mouse hippocampus.
      Title: A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus.
    Submit: New GeneRIF Correction

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to beta-catenin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    canonical Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    response to methylmercury IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Preferred Names
    transcription factor AP-1
    Names
    transcription factor AP-1
    v-jun sarcoma virus 17 oncogene homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199987.1 → NP_956281.1  transcription factor AP-1

      Status: PROVISIONAL

      Source sequence(s)
      BC056597
      UniProtKB/TrEMBL
      Q6NZT5
      Related
      ENSDARP00000063911, OTTDARP00000008939, ENSDART00000063912, OTTDART00000010376
      Conserved Domains (2) summary
      pfam03957
      Location:5 – 218
      Blast Score: 501
      Jun; Jun-like transcription factor
      pfam00170
      Location:227 – 290
      Blast Score: 204
      bZIP_1; bZIP transcription factor

    RefSeqs of Annotated Genomes: Build 5.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Zv9 Primary Assembly

    Genomic

    1. NC_007131.5 Reference Zv9 Primary Assembly

      Range
      15558608..15560467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic CR392368.7 (28050..29909) None
    mRNA BC056597.1 AAH56597.1
    mRNA BC065976.1 AAH65976.1
    mRNA DQ003340.1 AAY21257.1

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

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