RpL5 Ribosomal protein L5 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: RpL5provided by Flybase
Official Full Name: Ribosomal protein L5provided by Flybase
Primary source: FLYBASE:FBgn0064225
Locus tag: Dmel_CG17489
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17489; Dmel\CG17489; dRPL5; E-2d; L5; M(2)40B; yip6

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Genomic context

Location :: 40F7-40F7

Sequence :: Chromosome: 2L; NT_033779.4 (22427533..22429419, complement)

See RpL5 in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

eclipse might be a novel ribosome associated protein interacting with dRPL5
Title: Drosophila Ecp is a novel ribosome associated protein interacting with dRPL5.
RpL5, located in the centric heterochromatin of chromosome 2, was analyzed genetically.
Title: Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:78249	BioGRID:64483	Bet3	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:66072	CG10032	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:63998	CG11586	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:64120	CG13287	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:72489	CG14476	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:66938	CG14868	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:72825	CG18806	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:66123	CG2678	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:68662	CG32016	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:58683	CG32635	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:66963	CG4520	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:59559	CG5001	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:64737	CG5645	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:60341	CG9573	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:66217	CG9797	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:68567	CycG	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:61367	Ef2b	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:70621	Exp6	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:63147	Fmr1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:78249	BioGRID:69194	Lk6	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:63549	NaCP60E	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:68008	RASSF8	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:60239	Rbsn-5	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:57861	VhaAC39	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:64305	eIF4E-5	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:63243	fd59A	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:70067	kermit	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:65884	noi	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:57898	rb	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:59392	slgA	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:77769	squ	BioGRID	PubMed	Two-hybrid
BioGRID:78249	BioGRID:62662	veil	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the RpL5 gene: The RpL5 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice.

Pathways from BioSystems

Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
Cap-dependent Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytoplasmic Ribosomal Proteins, organism-specific biosystem (from WikiPathways)
Cytoplasmic Ribosomal Proteins, organism-specific biosystem
Cytoplasmic Ribosomal Proteins
Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Termination, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Termination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide chain elongation, organism-specific biosystem (from REACTOME)
Peptide chain elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ribosome, organism-specific biosystem (from KEGG)
Ribosome, organism-specific biosystem
Ribosome
Ribosome, conserved biosystem (from KEGG)
Ribosome, conserved biosystem
Ribosome
Ribosome, eukaryotes, organism-specific biosystem (from KEGG)
Ribosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; Ribosome
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
5S rRNA binding	IEA Inferred from Electronic Annotation more info
5S rRNA binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info
structural constituent of ribosome	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
translation	IEA Inferred from Electronic Annotation more info
translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cytosolic large ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
cytosolic large ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
ribosome	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG17489 gene product from transcript CG17489-RF

Names: CG17489-PA; CG17489-PB; CG17489-PF; RpL5-PA; RpL5-PB; RpL5-PF; enhancer on chromosome 2, complementation group d; ribosomal protein L5; yippee interacting protein 6

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

22427533..22429419, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169573.1 → NP_001163044.1 ribosomal protein L5, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q6NL81

Related

FBpp0290776, FBtr0301561

Conserved Domains (1) summary

pfam14204
Location:31 – 122
Blast Score: 368

Ribosomal_L18_c; Ribosomal L18 C-terminal region
NM_001042923.2 → NP_001036388.1 ribosomal protein L5, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W5R8

Related

FBpp0110424, FBtr0111132

Conserved Domains (3) summary

cd00432
Location:41 – 171
Blast Score: 216

Ribosomal_L18_L5e; Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA ...

PTZ00069
Location:1 – 298
Blast Score: 1150

PTZ00069; 60S ribosomal protein L5; Provisional

pfam14204
Location:193 – 284
Blast Score: 404

Ribosomal_L18_c; Ribosomal L18 C-terminal region
NM_001042922.2 → NP_001036387.1 ribosomal protein L5, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W5R8

Related

FBpp0110421, FBtr0111129

Conserved Domains (3) summary

cd00432
Location:41 – 171
Blast Score: 216

Ribosomal_L18_L5e; Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA ...

PTZ00069
Location:1 – 298
Blast Score: 1150

PTZ00069; 60S ribosomal protein L5; Provisional

pfam14204
Location:193 – 284
Blast Score: 404

Ribosomal_L18_c; Ribosomal L18 C-terminal region

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE014134.5	ACZ94330.1
mRNA	BT012458.1	AAS93729.1
mRNA	AY071305.1	AAL48927.1
genomic	AE014134.5	EAA46016.1
genomic	AE014134.5	EAA46019.1