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rl rolled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354888, updated on 14-Dec-2014
Official Symbol
rlprovided by FlyBase
Official Full Name
rolledprovided by FlyBase
Primary source
FLYBASE:FBgn0003256
Locus tag
Dmel_CG12559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12559; BcDNA:RE08694; CG12559; CG18732; CT34260; CT39192; D-ERK; dERK; DERK; DERK-A; dm-dpERK; Dmel\CG12559; DmErk; DmERK-A; DmERKA; DmMAPK; dp-ERK; dpErk; dpERk; dpERK; DpErk; DpERK; dpERK1; dpMAPK; Dsor2; E(sina)7; EK2-1; erk; Erk; ERK; ERK-A; Erk/Map kinase; Erk1; ErkA; ERKa; ERKA; EY2-2; GroupII; l(2)41Ac; l(2R)EMS45-39; MAP-k; mapk; Mapk; MapK; MAPK; pERK; pMapK; pMAPK; Rl; RL; rl/ERK; rl/MAPK; rll; sem; Sem; SEM; SR2-1; Su(Raf)2B
Location:
h41-h41; 2-55.1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.01 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1071462..1125927)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (198176..252641)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene CG40498 gene product from transcript CG40498-RG Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
MAP kinase activity NAS
Non-traceable Author Statement
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
R7 cell development TAS
Traceable Author Statement
more info
PubMed 
adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior axis specification, embryo TAS
Traceable Author Statement
more info
PubMed 
behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
 
gastrulation NAS
Non-traceable Author Statement
more info
PubMed 
heart development NAS
Non-traceable Author Statement
more info
PubMed 
imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
metamorphosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse structure or activity TAS
Traceable Author Statement
more info
PubMed 
regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
sevenless signaling pathway NAS
Non-traceable Author Statement
more info
 
torso signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
CG12559 gene product from transcript CG12559-RC
Names
CG12559-PA
CG12559-PC
CG12559-PD
CG12559-PE
CG12559-PG
CG12559-PH
CG12559-PI
Diphospho-ERK
ERK
ERK/rolled
Erk MAP kinase
Extracellular-regulated kinase A
Extracellular-signal-related kinase A
MAP kinase
MAP-kinase
drosophila ERK
enhancer of seven in absentia 7
extracellular signal-regulated kinase
extracellular signal-regulated kinase A
mitogen activated protein kinase
mitogen-activated protein kinase
phospho-ERK
rl-PA
rl-PC
rl-PD
rl-PE
rl-PG
rl-PH
rl-PI
roll
rolled
sevenmaker
NP_001015121.3
NP_001015122.1
NP_001015123.1
NP_001104348.2
NP_001104349.1
NP_001104350.1
NP_001287635.1

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 

    Range
    1071462..1125927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015122.3NP_001015122.1  rolled, isoform C [Drosophila melanogaster]

    See proteins identical to NP_001015122.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40417
    Conserved Domains (2) summary
    cd07849
    Location:32366
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    smart00220
    Location:38326
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_001110878.4NP_001104348.2  rolled, isoform H [Drosophila melanogaster]

    See proteins identical to NP_001104348.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40417
    Conserved Domains (2) summary
    smart00220
    Location:3216
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09925
    Location:1256
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001300706.2NP_001287635.1  rolled, isoform I [Drosophila melanogaster]

    See proteins identical to NP_001287635.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40417
    Conserved Domains (2) summary
    cd07849
    Location:32366
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    smart00220
    Location:38326
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. NM_001015121.3NP_001015121.3  rolled, isoform G [Drosophila melanogaster]

    See proteins identical to NP_001015121.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40417
    Conserved Domains (2) summary
    cd07849
    Location:6321
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    smart00220
    Location:12281
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  5. NM_001015123.3NP_001015123.1  rolled, isoform D [Drosophila melanogaster]

    See proteins identical to NP_001015123.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40417
    Conserved Domains (2) summary
    cd07849
    Location:32366
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    smart00220
    Location:38326
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  6. NM_001110879.2NP_001104349.1  rolled, isoform E [Drosophila melanogaster]

    See proteins identical to NP_001104349.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40417
    Conserved Domains (2) summary
    cd07849
    Location:32366
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    smart00220
    Location:38326
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  7. NM_001110880.2NP_001104350.1  rolled, isoform A [Drosophila melanogaster]

    See proteins identical to NP_001104350.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y4W5
    Conserved Domains (1) summary
    cl09925
    Location:32134
    PKc_like; Protein Kinases, catalytic domain