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klhl10 kelch like family member 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354863, updated on 29-Dec-2023

Summary

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Official Symbol
klhl10provided by FlyBase
Official Full Name
kelch like family member 10provided by FlyBase
Primary source
FLYBASE:FBgn0040038
Locus tag
Dmel_CG12423
See related
AllianceGenome:FB:FBgn0040038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.152; CG12423; Dmel\CG12423; Klhl10
Summary
Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; protein ubiquitination; and sperm individualization. Part of Cul3-RING ubiquitin ligase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See klhl10 in Genome Data Viewer
Location:
chromosome: Unknown
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) Unplaced Scaffold NW_007931083.1 (53442..85529)

NW_007931083.1Genomic Context describing neighboring genes Neighboring gene Glycoprotein hormone alpha 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_007931083.1 Unplaced Scaffold Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids. Kaplan Y, et al. Dev Cell, 2010 Jul 20. PMID 20643358
  2. A comparative genomic approach using mouse and fruit fly data to discover genes involved in testis function in hymenopterans with a focus on Nasonia vitripennis. Lécureuil C, et al. BMC Ecol Evol, 2021 May 19. PMID 34011283, Free PMC Article
  3. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation. Aram L, et al. Dev Cell, 2016 Apr 4. PMID 27052834
  4. A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila. Arama E, et al. PLoS Biol, 2007 Oct. PMID 17880263, Free PMC Article
  5. Caspase-dependent non-apoptotic processes in development. Nakajima YI, et al. Cell Death Differ, 2017 Aug. PMID 28524858, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
kelch like family member 10
Names
CG12423-PA
CG12423-PB
klhl10-PA
klhl10-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NW_007931083.1 Reference assembly

    Range
    53442..85529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015101.2 → NP_001015101.2  kelch like family member 10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015101.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q500X7, Q6GKZ1, Q7PLC2
    Conserved Domains (6) summary
    smart00612
    Location:490 → 536
    Kelch; Kelch domain
    PHA03098
    Location:86 → 610
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:432 → 475
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:72 → 186
    BTB; BTB/POZ domain
    pfam01344
    Location:431 → 476
    Kelch_1; Kelch motif
    pfam07707
    Location:195 → 298
    BACK; BTB And C-terminal Kelch

  2. NM_001015100.2 → NP_001015100.2  kelch like family member 10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015100.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q500X7, Q6GKZ1, Q7PLC2
    Conserved Domains (6) summary
    smart00612
    Location:490 → 536
    Kelch; Kelch domain
    PHA03098
    Location:86 → 610
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:432 → 475
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:72 → 186
    BTB; BTB/POZ domain
    pfam01344
    Location:431 → 476
    Kelch_1; Kelch motif
    pfam07707
    Location:195 → 298
    BACK; BTB And C-terminal Kelch
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GKZ1 Q6GKZ1

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