FOXN2 forkhead box N2 [Homo sapiens] - Gene

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Summary

Official Symbol: FOXN2provided by HGNC
Official Full Name: forkhead box N2provided by HGNC
Primary source: HGNC:5281
See related: Ensembl:ENSG00000170802; HPRD:00882; MIM:143089; Vega:OTTHUMG00000129168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HTLF
Summary: This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 2p22-p16

Sequence :: Chromosome: 2; NC_000002.11 (48541795..48606434)

See FOXN2 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HLTF methylation may exist in gastric cardia dysplasia stages and may play important role in the development of gastric cardia adenocarcinoma.
Title: Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:109576	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-Western
BioGRID:109576	BioGRID:113622	USP7		BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding, bending	IBA Inferred from Biological aspect of Ancestor more info
double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
embryo development	IBA Inferred from Biological aspect of Ancestor more info
pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
regulation of sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Preferred Names: forkhead box protein N2

Names: forkhead box protein N2; human T-cell leukemia virus enhancer factor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002158.3 → NP_002149.2 forkhead box protein N2

Status: REVIEWED

Source sequence(s)

AA827684, AC091485, BC063305

Consensus CDS

CCDS1838.1

UniProtKB/Swiss-Prot

P32314

Related

ENSP00000343633, OTTHUMP00000159451, ENST00000340553, OTTHUMT00000251240

Conserved Domains (1) summary

cd00059
Location:112 – 190
Blast Score: 347

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

48541795..48606434

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

48277701..48342337

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC091485.8	AAY14813.1
mRNA	AA827684.1	None
mRNA	AK123200.1	None
mRNA	BC063305.1	AAH63305.1
mRNA	BC069731.1	AAH69731.1
mRNA	BQ025120.1	None
mRNA	CR749839.1	None
mRNA	U57029.1	AAB03504.1
other-genetic	EU446484.1	ABZ92013.1