dpp decapentaplegic [ Drosophila melanogaster ]

Gene ID: 33432, updated on 12-May-2012

Help top of page

Summary

Official Symbol: dppprovided by Flybase
Official Full Name: decapentaplegicprovided by Flybase
Primary source: FLYBASE:FBgn0000490
Locus tag: Dmel_CG9885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: blk; BMP; CG9885; Dm-DPP; Dmel\CG9885; Dpp; DPP; DPP-C; Hin-d; ho; l(2)10638; l(2)22Fa; l(2)k17036; M(2)23AB; M(2)LS1; shv; Tg; TGF-b; TGF-beta; TGFbeta

Help top of page

Genomic context

Location :: 22F1-22F3; 2-4.0 cM

Sequence :: Chromosome: 2L; NT_033779.4 (2428454..2459609)

See dpp in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decapentaplegic/bone morphogenetic protein (Dpp/BMP) signaling activity in PSC cells controls niche size. Activation of BMP signaling in the PSC requires expression of the Dally-like heparan-sulfate proteoglycan, under the control of Collier.
Title: Size control of the Drosophila hematopoietic niche by bone morphogenetic protein signaling reveals parallels with mammals.
decapentaplegic (dpp) is rapidly activated by wounds and represses the production of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial peptide expression after even a small wound.
Title: Multiple TGF-β superfamily signals modulate the adult Drosophila immune response.
we found that the Dpp response scales with the size of the growing tissue, notably, scaling is not perfect at all positions and scaling of target gene domains is ensured specifically where they define wing vein positions
Title: Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.
Results examine how the Dpp activation gradient in the Drosophila wing imaginal disc scales with disc size.
Title: Expansion-repression mechanism for scaling the Dpp activation gradient in Drosophila wing imaginal discs.
receptor-mediated transcytosis cannot account for Dpp gradient formation, supporting restricted extracellular diffusion as the main mechanism for Dpp dispersal
Title: Formation of the long range Dpp morphogen gradient.
Endomembrane-mediated processes contribute to the spread and maintenance of the Dpp gradient of the wing disc.
Title: Formation and maintenance of morphogen gradients: an essential role for the endomembrane system in Drosophila melanogaster wing development.
conclude that glutamate promotes dpp expression in corpus allatum, which stimulates juvenile hormone biosynthesis through Tkv and Mad by upregulating JH acid methyltransferase transcription at early larval stages to prevent premature metamorphosis
Title: DPP-mediated TGFbeta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase.
DALLY regulates DPP signaling in trans by its effect on the stability of DPP protein on the surface of the contacting cells
Title: Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans.
Dpp concentration and signaling levels during wing disc growth were quantified; both Dpp concentration and signaling gradients scale with tissue size during development
Title: Dynamics of Dpp signaling and proliferation control.
The activities of both Fat and Dpp signaling pathways are regulated in a parallel rather than sequential manner and that uniform proliferation is achieved by their complementary action on growth.
Title: Antagonistic growth regulation by Dpp and Fat drives uniform cell proliferation.

Submit: New GeneRIF Correction See all (110)

Help top of page

Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:59659	BioGRID:69370	CG42569	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:60939	CycE	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:64905	D	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:69651	E5	BioGRID	PubMed	Two-hybrid
BioGRID:59659	BioGRID:63083	Egfr	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:63578	Kr	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:59745	Mad	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:68568	Med	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:59275	Mer	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:60383	Pka-C1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:63974	Ras64B	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:66301	Ras85D	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:68116	Tl	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:63994	ago	BioGRID	PubMed	Two-hybrid
BioGRID:59659	BioGRID:57697	arm	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:57896	bi	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:69559	cv-2	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:70073	cype	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:60991	dac	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:64418	dally	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:68643	ey	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:60071	eya	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:59824	ft	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:63372	gbb	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:58642	hep	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:67682	hh	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:59421	l(2)gl	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:62687	lack	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:59717	lilli	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:69974	nec	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:68673	nej	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:64316	nmo	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:67162	osa	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:60814	p38b	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:57908	peb	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:69326	pnr	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:61701	ptc	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:66141	puc	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:63708	rho	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:61598	sax	BioGRID	PubMed	Phenotypic Suppression
	NP_524863.3	scw	BIND	PubMed	An unspecified isoform of Dpp interacts with Scw.
BioGRID:59659	BioGRID:70052	scw	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:61969	shn	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:59452	smo	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:61542	so	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:58848	sog	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:61229	spi	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:59924	tkv	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:67870	tld	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:61589	tor	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:59659	BioGRID:68659	toy	BioGRID	PubMed	Two-hybrid
BioGRID:59659	BioGRID:58565	tsg	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:64117	vn	BioGRID	PubMed	Phenotypic Suppression
BioGRID:59659	BioGRID:59930	vri	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:59659	BioGRID:60155	wg	BioGRID	PubMed	Phenotypic Suppression

Help top of page

General gene information

Markers

Dm0672 (e-PCR)
- UniSTS:55221

Homology

Homologs of the dpp gene: The dpp gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

Pathways from BioSystems

Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
Hedgehog signaling pathway, conserved biosystem (from KEGG)
Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by BMP, organism-specific biosystem (from REACTOME)
Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
growth factor activity	IEA Inferred from Electronic Annotation more info
morphogen activity	NAS Non-traceable Author Statement more info
morphogen activity	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info
transforming growth factor beta receptor binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
BMP signaling pathway	NAS Non-traceable Author Statement more info	PubMed
BMP signaling pathway	TAS Traceable Author Statement more info	PubMed
Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info
amnioserosa formation	NAS Non-traceable Author Statement more info	PubMed
amnioserosa formation	TAS Traceable Author Statement more info	PubMed
anterior/posterior axis specification	TAS Traceable Author Statement more info	PubMed
anterior/posterior pattern specification, imaginal disc	NAS Non-traceable Author Statement more info	PubMed
branch fusion, open tracheal system	TAS Traceable Author Statement more info	PubMed
branched duct epithelial cell fate determination, open tracheal system	TAS Traceable Author Statement more info	PubMed
cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cell fate determination	TAS Traceable Author Statement more info	PubMed
cell fate specification	NAS Non-traceable Author Statement more info	PubMed
cell fate specification	TAS Traceable Author Statement more info	PubMed
chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
compound eye morphogenesis	TAS Traceable Author Statement more info	PubMed
developmental pigmentation	TAS Traceable Author Statement more info	PubMed
dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal closure	NAS Non-traceable Author Statement more info	PubMed
dorsal closure	TAS Traceable Author Statement more info	PubMed
dorsal closure, leading edge cell fate determination	NAS Non-traceable Author Statement more info	PubMed
dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal/ventral axis specification	NAS Non-traceable Author Statement more info	PubMed
dorsal/ventral axis specification	TAS Traceable Author Statement more info	PubMed
dorsal/ventral pattern formation, imaginal disc	TAS Traceable Author Statement more info	PubMed
ectoderm development	TAS Traceable Author Statement more info	PubMed
ectodermal cell fate specification	NAS Non-traceable Author Statement more info	PubMed
embryo development	NAS Non-traceable Author Statement more info
epithelial cell fate determination, open tracheal system	TAS Traceable Author Statement more info	PubMed
epithelial cell migration, open tracheal system	TAS Traceable Author Statement more info	PubMed
eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
foregut morphogenesis	TAS Traceable Author Statement more info	PubMed
fusion cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
genital disc anterior/posterior pattern formation	IEP Inferred from Expression Pattern more info	PubMed
genital disc development	IMP Inferred from Mutant Phenotype more info	PubMed
genital disc development	TAS Traceable Author Statement more info	PubMed
genital disc sexually dimorphic development	IMP Inferred from Mutant Phenotype more info	PubMed
germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
germ-line stem cell division	TAS Traceable Author Statement more info	PubMed
germ-line stem cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
heart development	TAS Traceable Author Statement more info	PubMed
hemocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
hindgut morphogenesis	TAS Traceable Author Statement more info	PubMed
imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc development	NAS Non-traceable Author Statement more info
imaginal disc development	TAS Traceable Author Statement more info	PubMed
imaginal disc growth	TAS Traceable Author Statement more info	PubMed
imaginal disc pattern formation	NAS Non-traceable Author Statement more info	PubMed
imaginal disc pattern formation	TAS Traceable Author Statement more info	PubMed
imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived wing morphogenesis	TAS Traceable Author Statement more info	PubMed
imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived wing vein specification	TAS Traceable Author Statement more info	PubMed
instar larval development	NAS Non-traceable Author Statement more info
labial disc development	IMP Inferred from Mutant Phenotype more info	PubMed
larval lymph gland hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
leg disc proximal/distal pattern formation	NAS Non-traceable Author Statement more info	PubMed
leg disc proximal/distal pattern formation	TAS Traceable Author Statement more info	PubMed
lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
maternal specification of dorsal/ventral axis, oocyte, soma encoded	IMP Inferred from Mutant Phenotype more info	PubMed
mesoderm development	TAS Traceable Author Statement more info	PubMed
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
negative regulation of gene expression	IEP Inferred from Expression Pattern more info	PubMed
negative regulation of salivary gland boundary specification	TAS Traceable Author Statement more info	PubMed
nurse cell apoptosis	NAS Non-traceable Author Statement more info
oogenesis	TAS Traceable Author Statement more info	PubMed
open tracheal system development	NAS Non-traceable Author Statement more info	PubMed
open tracheal system development	TAS Traceable Author Statement more info	PubMed
ovarian follicle cell development	TAS Traceable Author Statement more info	PubMed
pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
progression of morphogenetic furrow involved in compound eye morphogenesis	TAS Traceable Author Statement more info	PubMed
regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info
regulation of cell proliferation	NAS Non-traceable Author Statement more info	PubMed
regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of organ growth	TAS Traceable Author Statement more info	PubMed
regulation of tube diameter, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
sensory organ development	TAS Traceable Author Statement more info	PubMed
stem cell division	TAS Traceable Author Statement more info	PubMed
stem cell maintenance	NAS Non-traceable Author Statement more info	PubMed
transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
wing and notum subfield formation	IMP Inferred from Mutant Phenotype more info	PubMed
wing disc anterior/posterior pattern formation	TAS Traceable Author Statement more info	PubMed
wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
wing disc proximal/distal pattern formation	TAS Traceable Author Statement more info	PubMed
zygotic determination of anterior/posterior axis, embryo	TAS Traceable Author Statement more info	PubMed
zygotic specification of dorsal/ventral axis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
extracellular region	NAS Non-traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
intracellular	IDA Inferred from Direct Assay more info	PubMed

Help top of page

General protein information

Preferred Names: CG9885 gene product from transcript CG9885-RA

Names: CG9885-PA; CG9885-PB; CG9885-PC; CG9885-PD; CG9885-PE; Decapentaplegic/Bone morphogenetic protein; Haplo-insufficient; blink; bone morphogenetic protein; bone morphogenic protein; decapentaplegic; dpp-PA; dpp-PB; dpp-PC; dpp-PD; dpp-PE; heldout; shortvein; tegula

Help top of page

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

2428454..2459609

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057963.4 → NP_477311.1 decapentaplegic, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P07713

Related

FBpp0077451, FBtr0077771

Conserved Domains (2) summary

pfam00688
Location:225 – 444
Blast Score: 303

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:487 – 588
Blast Score: 490

TGF_beta; Transforming growth factor beta like domain
NM_164485.1 → NP_722810.1 decapentaplegic, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P07713

Related

FBpp0077452, FBtr0077772

Conserved Domains (2) summary

pfam00688
Location:225 – 444
Blast Score: 303

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:487 – 588
Blast Score: 490

TGF_beta; Transforming growth factor beta like domain
NM_164486.1 → NP_722811.1 decapentaplegic, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P07713

Related

FBpp0077453, FBtr0077773

Conserved Domains (2) summary

pfam00688
Location:225 – 444
Blast Score: 303

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:487 – 588
Blast Score: 490

TGF_beta; Transforming growth factor beta like domain
NM_164487.1 → NP_722812.1 decapentaplegic, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P07713

Related

FBpp0077454, FBtr0077774

Conserved Domains (2) summary

pfam00688
Location:225 – 444
Blast Score: 303

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:487 – 588
Blast Score: 490

TGF_beta; Transforming growth factor beta like domain
NM_164488.1 → NP_722813.1 decapentaplegic, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P07713

Related

FBpp0077455, FBtr0077775

Conserved Domains (2) summary

pfam00688
Location:225 – 444
Blast Score: 303

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:487 – 588
Blast Score: 490

TGF_beta; Transforming growth factor beta like domain

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE014134.5	AAN10434.1
genomic	AE014134.5	AAN10431.1
genomic	AE014134.5	AAN10433.1
genomic	AE014134.5	AAF51250.1
genomic	AE014134.5	AAN10432.1