tdo2b tryptophan 2,3-dioxygenase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tdo2bprovided by ZNC
Official Full Name: tryptophan 2,3-dioxygenase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6014
See related: Ensembl:ENSDARG00000023176 AllianceGenome:ZFIN:ZDB-GENE-030131-6014
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Tdo2; tdo2l; fi30d08; zgc:63488; wu:fi30d08
Summary: Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (34084524..34097434, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (33821730..33834616, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 2,3-dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to acetyl-CoA	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tryptophan catabolic process to kynurenine	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to kynurenine	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process to kynurenine	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: tryptophan 2,3-dioxygenase B

Names: tryptophan 2,3-dioxygenase, like

NP_956150.1

EC 1.13.11.11

XP_021335229.1

EC 1.13.11.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199856.1 → NP_956150.1 tryptophan 2,3-dioxygenase B

See identical proteins and their annotated locations for NP_956150.1

Status: PROVISIONAL

Source sequence(s)

BC055123

UniProtKB/Swiss-Prot

Q7SY53

Related

ENSDARP00000035102.5, ENSDART00000028301.7

Conserved Domains (1) summary

pfam03301
Location:25 → 371

Trp_dioxygenase; Tryptophan 2,3-dioxygenase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

34084524..34097434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479554.1 → XP_021335229.1 tryptophan 2,3-dioxygenase B isoform X1

UniProtKB/TrEMBL

A0A8M9QCY2

Conserved Domains (1) summary

pfam03301
Location:21 → 367

Trp_dioxygenase; Tryptophan 2,3-dioxygenase