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    aop anterior open [ Drosophila melanogaster ]

    Gene ID: 33392, updated on 10-May-2012
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    Summary

    Official Symbol
    aopprovided by Flybase
    Official Full Name
    anterior openprovided by Flybase
    Primary source
    FLYBASE:FBgn0000097
    Locus tag
    Dmel_CG3166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aop; AOP; aop/yan; Aop/Yan; CG3166; Dmel\CG3166; DROYANET; DROYANETSB; fus6; pok; SK2-1; yan; Yan; YAN; yan/pok
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    Genomic context

    Location :
    22D1-22D1; 2-12 cM
    Sequence :
    Chromosome: 2L; NT_033779.4 (2156484..2178749, complement)
    See aop in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG7261 gene product from transcript CG7261-RA Neighboring gene Apoptosis inducing factor Neighboring gene CG15382 gene product from transcript CG15382-RA Neighboring gene transfer RNA:CR31946 Neighboring gene CG10874 gene product from transcript CG10874-RB

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis. Tokusumi T, et al. Development, 2011 Sep. PMID 21813570.
    2. Rapid evolutionary rewiring of a structurally constrained eye enhancer. Swanson CI, et al. Curr Biol, 2011 Jul 26. PMID 21737276.
    3. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Charlton-Perkins M, et al. Neural Dev, 2011 May 3. PMID 21539742.
    4. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Horn T, et al. Nat Methods, 2011 Apr. PMID 21378980.
    5. A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Weyers JJ, et al. Dev Biol, 2011 May 15. PMID 21377458.

    See all (228) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Bam and mir-7 antagonize the differentiation-promoting function of Yan to maintain the stem-like hematopoietic progenitor state during hematopoiesis.
      Title: Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis.
    2. full-length Yan self associates via its N-terminal sterile alpha motif (SAM) domain to form higher-order complexes in living cells
      Title: Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan.
    3. Fbl6 regulates Tel/Yan protein stability and allows appropriate spatiotemporal control of gene expression by these repressors.
      Title: Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination.
    4. Yan functions to modulate the turnover of DE-Cadherin-dependent adhesive complexes to facilitate border cell migration
      Title: Function of the ETS transcription factor Yan in border cell migration.
    5. results show that the dynamic expression of the yan gene is specified by distinct spatial and temporal cis-acting regulatory elements in embryos and larval tissues
      Title: Identifying functional cis-acting regulatory modules of the yan gene in Drosophila melanogaster.
    6. Yan regulates Lozenge during eye development
      Title: Yan regulates Lozenge during Drosophila eye development.
    7. A reversible loop of Yan phosphorylation implements a zero-order ultrasensitivity-like threshold mechanism, with the capacity to form sharp thresholds that are independent of the level of Yan.
      Title: Threshold responses to morphogen gradients by zero-order ultrasensitivity.
    8. prior to Ras activation, the Mae/Yan interaction blocks premature nuclear export of Yan monomers
      Title: Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response.
    9. Depolymerization of Yan by Mae represents a novel mechanism of transcriptional control that sensitizes Yan for regulation by receptor tyrosine kinases.
      Title: Derepression by depolymerization; structural insights into the regulation of Yan by Mae.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_722766.1 NP_722766.1 aop    BIND  PubMed Yan self-associates. 
    NP_722766.1 NP_523786.2 edl    BIND  PubMed Yan interacts with Mae. 
    NP_722766.1     BIND  PubMed Yan binds to DNA containing an Ets binding site (EBS). 
    BioGRID:59621 BioGRID:67207 14-3-3epsilon    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:59052 B-H1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:68534 CG1544    BioGRID  PubMed Two-hybrid 
    BioGRID:59621 BioGRID:64799 CG17666    BioGRID  PubMed Two-hybrid 
    BioGRID:59621 BioGRID:64510 CG3335    BioGRID  PubMed Two-hybrid 
    BioGRID:59621 BioGRID:66215 CG8159    BioGRID  PubMed Two-hybrid 
    BioGRID:59621 BioGRID:59074 CG8188    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:59621 BioGRID:58322 Dsor1    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:63083 Egfr    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:66386 Fancl    BioGRID  PubMed Two-hybrid 
    BioGRID:59621 BioGRID:64545 Gap1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:67421 H    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:61885 Jra    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:57823 N    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:66301 Ras85D    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:59534 S    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:62156 Sin3A    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:60899 Su(H)    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:65439 Su(Tpl)    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:65074 Taf4    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:69288 bsk    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:60711 bun    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:59819 ed    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:62822 edl    BioGRID  PubMed Biochemical Activity; Co-localization; Two-hybrid 
    BioGRID:59621 BioGRID:60071 eya    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:68590 faf    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:61996 fbl6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:59621 BioGRID:67226 gl    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:65868 ksr    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:59717 lilli    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:58331 lz    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:62308 mam    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:57758 phl    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:67700 pnt    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:66496 pros    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:69328 raw    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:70031 retn    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:63708 rho    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:78013 rl    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59621 BioGRID:68897 spen    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:68333 stg    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59621 BioGRID:63919 sty    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:66603 svp    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59621 BioGRID:71315 ttk    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    JNK cascade NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    MAPK cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    R3/R4 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    R7 cell development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    dorsal closure NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    dorsal closure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    induction of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of Ras protein signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of compound eye photoreceptor development NAS
    Non-traceable Author Statement
    more info
    		  
    negative regulation of photoreceptor cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oenocyte delamination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of R7 cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    regulation of hemocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG3166 gene product from transcript CG3166-RB
    Names
    CG3166-PA
    CG3166-PB
    SGP cluster fusion defects 6
    anterior open
    aop-PA
    aop-PB
    pokkuri
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      2156484..2178749, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078731.2 → NP_523455.2  anterior open, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01842
      Related
      FBpp0077522, FBtr0077850
      Conserved Domains (2) summary
      cd08535
      Location:49 – 116
      Blast Score: 338
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      cl02599
      Location:395 – 481
      Blast Score: 404
      Ets; Ets-domain

    2. NM_164457.1 → NP_722766.1  anterior open, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01842
      Related
      FBpp0077523, FBtr0077851
      Conserved Domains (2) summary
      cd08535
      Location:49 – 116
      Blast Score: 338
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      cl02599
      Location:395 – 481
      Blast Score: 404
      Ets; Ets-domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014134.5 AAN10445.1
    genomic AE014134.5 AAF51297.1
    mRNA BT015272.1 AAT94501.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01842.2 GenPept
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    Additional Links

    Gene LinkOut

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