My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    Su(dx) Suppressor of deltex [ Drosophila melanogaster ]

    Gene ID: 33379, updated on 12-May-2012
    Help top of page

    Summary

    Official Symbol
    Su(dx)provided by Flybase
    Official Full Name
    Suppressor of deltexprovided by Flybase
    Primary source
    FLYBASE:FBgn0003557
    Locus tag
    Dmel_CG4244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0073329.1; anon-WO0073329.2; anon-WO0073329.4; CG4244; Dmel\CG4244; Su(deltex); su(dx); Su(Dx)
    Help top of page

    Genomic context

    Location :
    22C1-22C1
    Sequence :
    Chromosome: 2L; NT_033779.4 (2037802..2044373)
    See Su(dx) in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG42296 gene product from transcript CG42296-RA Neighboring gene CG42295 gene product from transcript CG42295-RB Neighboring gene CG31672 gene product from transcript CG31672-RA Neighboring gene Odorant receptor 22c

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue. Djiane A, et al. J Cell Biol, 2011 Jan 10. PMID 21200027.
    3. Drosophila Ndfip is a novel regulator of Notch signaling. Dalton HE, et al. Cell Death Differ, 2011 Jul. PMID 20966964.
    4. Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis P, et al. BMC Dev Biol, 2010 Oct 19. PMID 20959007.
    5. A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Saj A, et al. Dev Cell, 2010 May 18. PMID 20493818.

    See all (37) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A core antagonistic interaction between Pyd and the WW domain E3 ubiquitin ligase Su(dx), was identified.
      Title: Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue.
    2. Su(dx) regulates the level of Notch signalling in vivo, upstream of Notch target genes and in different developmental contexts, including a previously unknown role in leg joint formation
      Title: Down-regulation of Notch target gene expression by Suppressor of deltex.
    Submit: New GeneRIF Correction
    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_476753.1 NP_476859.2 N    BIND  PubMed Notch interacts with Su(dx). 
    BioGRID:59611 BioGRID:66107 CG11286    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:64120 CG13287    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:72605 CG14767    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:59611 BioGRID:77848 CG42676    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:63764 Cdc37    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:67310 Dl    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59611 BioGRID:67421 H    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59611 BioGRID:68052 HLHmbeta    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59611 BioGRID:59745 Mad    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:57823 N    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59611 BioGRID:65246 Nedd4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:59611 BioGRID:68766 Sucb    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:58076 dx    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59611 BioGRID:64093 l(3)psg2    BioGRID  PubMed Two-hybrid 
    BioGRID:59611 BioGRID:64936 mop    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Homology

    • Homologs of the Su(dx) gene: The Su(dx) gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ubiquitin-protein ligase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    imaginal disc-derived leg joint morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    imaginal disc-derived wing margin morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    imaginal disc-derived wing vein morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    CG4244 gene product from transcript CG4244-RB
    Names
    CG4244-PA
    CG4244-PB
    CG4244-PC
    Su(dx)-PA
    Su(dx)-PB
    Su(dx)-PC
    suppressor of deltex
    NP_476753.1
    NP_722753.1
    NP_722754.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      2037802..2044373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057405.2 → NP_476753.1  suppressor of deltex, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY9
      UniProtKB/Swiss-Prot
      Q9Y0H4
      Related
      FBpp0077495, FBtr0077822
      Conserved Domains (4) summary
      cd00078
      Location:594 – 946
      Blast Score: 1073
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:398 – 426
      Blast Score: 124
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04021
      Location:48 – 173
      Blast Score: 470
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:620 – 946
      Blast Score: 1114
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

    2. NM_164448.1 → NP_722753.1  suppressor of deltex, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY9
      UniProtKB/Swiss-Prot
      Q9Y0H4
      Related
      FBpp0077496, FBtr0077823
      Conserved Domains (4) summary
      cd00078
      Location:594 – 946
      Blast Score: 1073
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:398 – 426
      Blast Score: 124
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04021
      Location:48 – 173
      Blast Score: 470
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:620 – 946
      Blast Score: 1114
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

    3. NM_164449.1 → NP_722754.1  suppressor of deltex, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY9
      UniProtKB/Swiss-Prot
      Q9Y0H4
      Related
      FBpp0077497, FBtr0077824
      Conserved Domains (4) summary
      cd00078
      Location:594 – 946
      Blast Score: 1073
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:398 – 426
      Blast Score: 124
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04021
      Location:48 – 173
      Blast Score: 470
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:620 – 946
      Blast Score: 1114
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014134.5 AAF51311.1
    genomic AE014134.5 AAF51312.1
    mRNA AF152865.1 AAD38975.1
    genomic AE014134.5 AAN10440.1
    mRNA BT021390.1 AAX33538.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y0H4.1 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

      Supplemental Content

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...