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    APLP1 amyloid beta (A4) precursor-like protein 1 [ Homo sapiens (human) ]

    Gene ID: 333, updated on 9-Jun-2013
    Official Symbol
    APLP1provided by HGNC
    Official Full Name
    amyloid beta (A4) precursor-like protein 1provided by HGNC
    Primary source
    HGNC:597
    See related
    Ensembl:ENSG00000105290; HPRD:00102; MIM:104775; Vega:OTTHUMG00000180692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APLP
    Summary
    This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Location :
    19q13.1
    Sequence :
    Chromosome: 19; NC_000019.9 (36359401..36370699)
    See APLP1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene nephrosis 1, congenital, Finnish type (nephrin) Neighboring gene kin of IRRE like 2 (Drosophila) Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta Neighboring gene hematopoietic cell signal transducer

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. APLP1 and Rab5A interact with the II-III loop of the voltage-gated Ca-channel Ca(v)2.3 and modulate its internalization differently. Radhakrishnan K, et al. Cell Physiol Biochem, 2011. PMID 22178872.
    2. Structural aspects and physiological consequences of APP/APLP trans-dimerization. Baumkötter F, et al. Exp Brain Res, 2012 Apr. PMID 21952790.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. The E2 domains of APP and APLP1 share a conserved mode of dimerization. Lee S, et al. Biochemistry, 2011 Jun 21. PMID 21574595.
    5. Signaling via amyloid precursor-like proteins APLP1 and APLP2. Orcholski ME, et al. J Alzheimers Dis, 2011. PMID 21178287.

    See all (42) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. [review] APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis.
      Title: Structural aspects and physiological consequences of APP/APLP trans-dimerization.
    2. APLP1 binds the II-III loop of the Ca(v)2.3 calcium channel and that this binding promotes internalization of the channel.
      Title: APLP1 and Rab5A interact with the II-III loop of the voltage-gated Ca-channel Ca(v)2.3 and modulate its internalization differently.
    3. Both APLP1 and APLP2, form transcriptionally active triple protein complexes with Mint3 and transcriptional co-activators Taz andYap.
      Title: Signaling via amyloid precursor-like proteins APLP1 and APLP2.
    4. The 2.1 A resolution electron density map reveals phosphate ions that are bound to the protein surface. Mutational analysis shows that protein residues interacting with the phosphate ions are also involved in heparin binding.
      Title: The E2 domains of APP and APLP1 share a conserved mode of dimerization.
    5. Human cerebrospinal fluid contains three APLP1-derived Abeta-like peptides that are generated by beta- and gamma-cleavages at a concentration of approximately 4.5 nM.
      Title: The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.
    6. neither cell-derived nor chemically synthesized APLP1-derived peptide influences the oligomerization or aggregation of Abeta
      Title: gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.
    7. Coexpression of APP with APLP1 or APLP2 leads to diminished generation of Abeta42
      Title: Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.
    8. APLP1 is differentially upregulated in gastrointestinal neuroendocrine tumours and may be important for the dissemination of small intestinal carcinoids
      Title: Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract.
    9. These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking.
      Title: Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase.
    10. APLP1 affects the endocytosis of APP and makes more APP available for alpha-secretase cleavage
      Title: Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.
    Submit: New GeneRIF Correction See all (15)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    P51693 O00213 APBB1    HPRD  PubMed  
    P51693 P42773 CDKN2C    HPRD  PubMed  
    P51693 Q9UGL9 CRCT1    HPRD  PubMed  
    P51693 O75553 DAB1    HPRD  PubMed  
    P51693 P20042 EIF2S2    HPRD  PubMed  
    P51693 Q03013 GSTM4    HPRD  PubMed  
    P51693 P01909 HLA-DQA1    HPRD  PubMed  
    P51693 P61604 HSPE1    HPRD  PubMed  
    P51693 Q99547 MPHOSPH6    HPRD  PubMed  
    P51693 Q13765 NACA    HPRD  PubMed  
    P51693 Q9UN74 PCDHA4    HPRD  PubMed  
    P51693 Q8WUB8 PHF10    HPRD  PubMed  
    P51693 P00491 PNP    HPRD  PubMed  
    P51693 P04156 PRNP    HPRD  PubMed  
    P51693 P21673 SAT1    HPRD  PubMed  
    P51693 Q13190 STX5    HPRD  PubMed  
    P51693 O43680 TCF21    HPRD  PubMed  
    P51693 P04183 TK1    HPRD  PubMed  
    P51693 P62328 TMSB4X    HPRD  PubMed  
    P51693 Q96GM8 TOE1    HPRD  PubMed  
    P51693 Q15714 TSC22D1    HPRD  PubMed  
    P51693 Q9BVJ6 UTP14A    HPRD  PubMed  
    P51693 P17028 ZNF24    HPRD  PubMed  
    BioGRID:106830 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:106819 APBB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106830 BioGRID:115593 APBB3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106830 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106830 BioGRID:198141 Apbb1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:107454 CDK4    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:107465 CDKN2C    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:120031 CRCT1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:107843 CSNK2B    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:107970 DAB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106830 BioGRID:107971 DAB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106830 BioGRID:108237 EEF1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:114411 EIF2S2    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:108930 GDF9    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:109203 GSTM4    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:114480 HAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:109362 HLA-DQA1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:109568 HSPE1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:124016 ING5    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:115779 KAT5    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:115495 MPHOSPH6    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:110748 NACA    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:121084 PCDHA4    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:120562 PHF10    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:111317 PIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:110921 PNP    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:111843 RAP1B    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:123855 RBM48    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:107529 RCC1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:112506 SNCA    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:112680 STX5    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:112803 TCF21    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:125269 TOE1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:114374 TSC22D1    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:202471 Tmsb4x    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:116026 UTP14A    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:113272 VIM    BioGRID  PubMed Two-hybrid 
    BioGRID:106830 BioGRID:113403 ZNF24    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-2A adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    alpha-2B adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    alpha-2C adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to norepinephrine stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA polyadenylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    basement membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    amyloid-like protein 1
    Names
    amyloid-like protein 1
    APLP-1
    amyloid precursor-like protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024807.1 → NP_001019978.1  amyloid-like protein 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AD000864, BC012889, BC013850, BQ219233
      Consensus CDS
      CCDS32997.1
      UniProtKB/Swiss-Prot
      P51693
      Related
      ENSP00000221891, OTTHUMP00000264975, ENST00000221891, OTTHUMT00000452564
      Conserved Domains (5) summary
      smart00006
      Location:55 – 211
      Blast Score: 736
      A4_EXTRA; amyloid A4
      pfam10515
      Location:595 – 648
      Blast Score: 172
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam02177
      Location:55 – 154
      Blast Score: 405
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam12924
      Location:155 – 211
      Blast Score: 280
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:284 – 468
      Blast Score: 607
      APP_E2; E2 domain of amyloid precursor protein

    2. NM_005166.3 → NP_005157.1  amyloid-like protein 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AD000864, BC012889, BQ219233
      UniProtKB/Swiss-Prot
      P51693
      Conserved Domains (5) summary
      smart00006
      Location:55 – 211
      Blast Score: 736
      A4_EXTRA; amyloid A4
      pfam10515
      Location:594 – 647
      Blast Score: 172
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam02177
      Location:55 – 154
      Blast Score: 404
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam12924
      Location:155 – 211
      Blast Score: 280
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:284 – 468
      Blast Score: 607
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      36359401..36370699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      32864721..32875938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      36518346..36529644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01018771.1 (36232..37044) None
    genomic ABBA01018772.1 None
    genomic AD000864.1 AAB50173.1
    genomic AMYH01009735.1 (43325..54623) None
    mRNA AK092376.1 None
    mRNA AK126907.1 None
    mRNA AK297339.1 BAH12554.1
    mRNA AK297640.1 BAH12638.1
    mRNA AK312292.1 BAG35219.1
    mRNA BC012889.1 AAH12889.1
    mRNA BC013850.1 None
    mRNA BC032983.1 None
    mRNA BQ219233.1 None
    mRNA EF036503.1 ABO65089.1
    mRNA U48437.1 AAB96331.1
    other-genetic DQ891341.2 ABM82267.1
    other-genetic DQ894523.2 ABM85449.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51693.3 GenPept UniProtKB/Swiss-Prot:P51693

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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