BIRC5 baculoviral IAP repeat containing 5 [Homo sapiens] - Gene

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Summary

Official Symbol: BIRC5provided by HGNC
Official Full Name: baculoviral IAP repeat containing 5provided by HGNC
Primary source: HGNC:593
See related: Ensembl:ENSG00000089685; HPRD:04520; MIM:603352
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: API4; EPR-1
Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

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Genomic context

Location :: 17q25

Sequence :: Chromosome: 17; NC_000017.10 (76210277..76221716)

See BIRC5 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Survivin primarily recognizes N-terminal Ala1 of H3, H3T3ph, and SmacN peptides and exhibits a 25-fold preference for H3T3ph over SamcN peptide.
Title: Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin.
Nuclear accumulation of Survivin and interaction with components of the DNA-double-strand break (DSB) repair machinery indicates Survivin to regulate DSB damage repair that leads to a significant improvement of survival of LN229 glioblastoma cells.
Title: Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.
Data suggest that expression of survivin mRNA and protein in preeclamptic placenta is significantly reduced compared to that in normal placenta; these levels are significantly reduced in severe preeclampsia compared to mild preeclampsia.
Title: Reduced expression of survivin, the inhibitor of apoptosis protein correlates with severity of preeclampsia.
results demonstrate that Aurora B confers TRAIL resistance to cancer cells via phosphorylation of survivin.
Title: Aurora B confers cancer cell resistance to TRAIL-induced apoptosis via phosphorylation of survivin.
These results suggest that survivin gene polymorphisms and their interactions with environmental carcinogens may increase susceptibility to oral cancer in Taiwanese men.
Title: Survivin SNP-carcinogen interactions in oral cancer.
An important role of survivin -31 G/C polymorphism with cancer risk especially in Asian population.
Title: Survivin promoter -31G/C (rs9904341) polymorphism and cancer susceptibility: a meta-analysis.
A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation.
Title: Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
Describe the baseline levels of urine levels of survivin after radical cystectomy for primary invasive bladder cancer.
Title: Detection of nuclear matrix protein 22 and survivin baseline level in patients after radical cystectomy.
Survivin is expressed at protein and mRNA levels in human osteoarthritic cartilage-- the so-called chondroid nests, comprising accumulations of "stressed" chondrocytes where survivin gene transcription and translation are reactivated.
Title: The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro.
Survivin is a novel target of CD44-promoted breast tumor invasion
Title: Survivin is a novel target of CD44-promoted breast tumor invasion.

Submit: New GeneRIF Correction See all (603)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates survivin expression by transactivating the survivin promoter	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001159.1	NP_004208.1	AURKB	BIND	PubMed	HsAIRK-2 interacts with survivin in the RasGAP/HsAIRK-2/survivin complex. This interaction was modelled on a demonstrated interaction between human HsAIRK-2 and monkey survivin.
NP_001159.1	NP_064623.1	INCENP	BIND	PubMed	Survivin interacts with INCENP. This interaction was modelled on a demonstrated interaction between human survivin and chicken INCENP.
NP_001159.2	NP_001012270.1	BIRC5	BIND	PubMed	Survivin interacts with survivin-deltaEx3.
NP_001159.2	NP_001012271.1	BIRC5	BIND	PubMed	Survivin interacts with Survivin-2B.
NP_001159.2	NP_001159.2	BIRC5	BIND	PubMed	Interaction between survivin (PDB ID: 1F3H_B) and survivin (PDB ID: 1F3H_A).
NP_001159.2	NP_005339.2	HSP90AA1	BIND	PubMed	Survivin interacts with Hsp90.
O15392	Q96GD4	AURKB	HPRD	PubMed
O15392	O15392	BIRC5	HPRD	PubMed
O15392	P42574	CASP3	HPRD	PubMed
O15392	P55210	CASP7	HPRD	PubMed
O15392	P55211	CASP9	HPRD	PubMed
O15392	Q53HL2	CDCA8	HPRD	PubMed
O15392	P06493	CDK1	HPRD	PubMed
O15392	P11802	CDK4	HPRD	PubMed
O15392	Q9NR28	DIABLO	HPRD	PubMed
O15392	P07900	HSP90AA1	HPRD	PubMed
O15392	Q9NQS7	INCENP	HPRD	PubMed
O15392	P20936	RASA1	HPRD	PubMed
O15392	P98170	XIAP	HPRD	PubMed
O15392	O14980	XPO1	HPRD	PubMed
U75285.1	NP_005216.1	E2F1	BIND	PubMed	E2F1 (E2F-1) interacts with the BIRC5 (survivin) promoter.
U75285.1	NP_001940.1	E2F3	BIND	PubMed	E2F3 (E2F-3) interacts with the BIRC5 (survivin) promoter.
U75285.1	NP_001941.2	E2F4	BIND	PubMed	E2F4 (E2F-4) interacts with the BIRC5 (survivin) promoter.
U75285.1	NP_001942.1	E2F5	BIND	PubMed	E2F5 (E2F-5) interacts with the BIRC5 (survivin) promoter.
U75285.1	NP_000312.1	RB1	BIND	PubMed	RB1 (pRB) interacts with the BIRC5 (survivin) promoter.
U75285.1	NP_005602.2	RBL2	BIND	PubMed	RBL2 (p130) interacts with the BIRC5 (survivin) promoter.
BioGRID:106829	BioGRID:114646	AURKB	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:106829	BioGRID:106826	BIRC2	BioGRID	PubMed	Reconstituted Complex
BioGRID:106829	BioGRID:106827	BIRC3	BioGRID	PubMed	Reconstituted Complex
BioGRID:106829	BioGRID:106829	BIRC5	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:106829	BioGRID:107286	CASP3	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106829	BioGRID:107290	CASP7	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:106829	BioGRID:107292	CASP9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:120446	CDCA8	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106829	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:107454	CDK4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:121157	DIABLO	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106829	BioGRID:113584	EVI5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106829	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:109831	INCENP	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:106829	BioGRID:676530	INCENP	BioGRID	PubMed	Two-hybrid
BioGRID:106829	BioGRID:200760	Incenp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106829	BioGRID:109965	KCNJ6	BioGRID	PubMed	Reconstituted Complex
BioGRID:106829	BioGRID:115014	MDC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:111577	PRKDC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106829	BioGRID:113200	UFD1L	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:113238	USF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106829	BioGRID:113867	USP9X	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106829	BioGRID:106828	XIAP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106829	BioGRID:113348	XPO1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106829	BioGRID:108822	XRCC6	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
Ran GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
cobalt ion binding	NAS Non-traceable Author Statement more info	PubMed
cofactor binding	IDA Inferred from Direct Assay more info	PubMed
cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
microtubule binding	IDA Inferred from Direct Assay more info	PubMed
microtubule binding	TAS Traceable Author Statement more info
peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
tubulin binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
M phase of mitotic cell cycle	TAS Traceable Author Statement more info
anti-apoptosis	IDA Inferred from Direct Assay more info	PubMed
cell division	IEA Inferred from Electronic Annotation more info
cell division	IMP Inferred from Mutant Phenotype more info	PubMed
chromosome segregation	IEA Inferred from Electronic Annotation more info
cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
establishment of chromosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
mitosis	TAS Traceable Author Statement more info	PubMed
mitotic cell cycle	TAS Traceable Author Statement more info
mitotic prometaphase	TAS Traceable Author Statement more info
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info
positive regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
protein complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info
regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info
spindle checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
centriole	IDA Inferred from Direct Assay more info	PubMed
chromosome passenger complex	IPI Inferred from Physical Interaction more info	PubMed
chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
condensed chromosome kinetochore	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
interphase microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
midbody	IDA Inferred from Direct Assay more info	PubMed
nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
spindle	IEA Inferred from Electronic Annotation more info
spindle microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: baculoviral IAP repeat-containing protein 5

Names: baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029069.1 RefSeqGene

Range

5001..16440

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001012270.1 → NP_001012270.1 baculoviral IAP repeat-containing protein 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as survivin-deltaEx3, lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AI800528, AL519719, AL547142, BC008718, BG178974, BI254058, BI520186, BM476145

Consensus CDS

CCDS32751.1

UniProtKB/Swiss-Prot

O15392

Related

ENSP00000364086, ENST00000374948

Conserved Domains (1) summary

cd00022
Location:16 – 76
Blast Score: 163

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
NM_001012271.1 → NP_001012271.1 baculoviral IAP repeat-containing protein 5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as survivin-2B, includes an alternate in-frame segment, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct sequence when it is compared to isoform 1.

Source sequence(s)

AB028869, AI800528, AL519719, BC008718, BE537971, BG759111, BI254058, BI520186, BQ687404, CB112371

Consensus CDS

CCDS32752.1

UniProtKB/TrEMBL

H3BLT4

UniProtKB/Swiss-Prot

O15392

Related

ENSP00000301633, ENST00000301633

Conserved Domains (1) summary

cd00022
Location:16 – 110
Blast Score: 180

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
NM_001168.2 → NP_001159.2 baculoviral IAP repeat-containing protein 5 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the most frequently occurring transcript and it encodes isoform 1.

Source sequence(s)

AI800528, AL519719, BC008718, BC034148, BG759111, BI254058, BI520186

Consensus CDS

CCDS11755.1

UniProtKB/Swiss-Prot

O15392

Related

ENSP00000324180, ENST00000350051

Conserved Domains (1) summary

cd00022
Location:16 – 87
Blast Score: 208

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

76210277..76221716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

71634433..71645847

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC087645.19 (116490..127929)	None
genomic	AY795969.1	AAV40840.1
genomic	CH471099.1	EAW89511.1
		EAW89512.1
		EAW89513.1
		EAW89514.1
genomic	JA362594.1	CCA94579.1
genomic	U75285.1	AAC51660.1
mRNA	AB028869.1	BAA93676.1
mRNA	AB154416.1	BAD11155.1
mRNA	AF077350.1	AAD34226.1
mRNA	AI800528.1	None
mRNA	AK223428.1	BAD97148.1
mRNA	AK301793.1	BAH13555.1
mRNA	AK311917.1	BAG34858.1
mRNA	AL519719.3	None
mRNA	AL547142.3	None
mRNA	AY830084.1	AAW22624.1
mRNA	AY927772.1	AAY15202.1
mRNA	BC000784.2	None
mRNA	BC008718.2	AAH08718.1
mRNA	BC034148.1	AAH34148.1
mRNA	BC065497.1	AAH65497.1
mRNA	BE537971.1	None
mRNA	BG178974.1	None
mRNA	BG759111.1	None
mRNA	BI254058.1	None
mRNA	BI520186.1	None
mRNA	BM476145.1	None
mRNA	BQ687404.1	None
mRNA	CB112371.1	None
mRNA	CR541740.1	CAG46540.1
mRNA	DQ227257.1	ABB76601.1
mRNA	DQ310375.1	ABC42341.1
mRNA	DQ310376.1	ABC42342.1
mRNA	DQ310377.1	ABC42343.1
mRNA	DQ310378.1	ABC42344.1
mRNA	DQ310379.1	ABC42345.1
mRNA	DQ508245.1	ABF60110.1
mRNA	DQ508246.1	ABF60111.1
mRNA	DQ508247.1	ABF60112.1
mRNA	DQ508248.1	ABF60113.1
mRNA	DQ508249.1	ABF60114.1
mRNA	HM625836.1	ADM26643.1
other-genetic	AM393128.1	CAL38006.1