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    HSPB2 heat shock 27kDa protein 2 [ Homo sapiens (human) ]

    Gene ID: 3316, updated on 14-May-2013
    Official Symbol
    HSPB2provided by HGNC
    Official Full Name
    heat shock 27kDa protein 2provided by HGNC
    Primary source
    HGNC:5247
    See related
    HPRD:03712; MIM:602179; Vega:OTTHUMG00000166886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKBP; HSP27; Hs.78846; LOH11CR1K
    Summary
    The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
    Location :
    11q22-q23
    Sequence :
    Chromosome: 11; NC_000011.9 (111783460..111784817)
    See HSPB2 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene 8 Neighboring gene HSPB2-C11orf52 readthrough (NMD candidate) Neighboring gene crystallin, alpha B Neighboring gene chromosome 11 open reading frame 52 Neighboring gene DIX domain containing 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Binding determinants of the small heat shock protein, αB-crystallin: recognition of the 'IxI' motif. Delbecq SP, et al. EMBO J, 2012 Dec 12. PMID 23188086.
    2. Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway. Ahner A, et al. Mol Biol Cell, 2013 Jan. PMID 23155000.
    3. HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects. Prabhu S, et al. PLoS One, 2012. PMID 22272249.
    4. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    5. Inhibition of α-synuclein aggregation by small heat shock proteins. Bruinsma IB, et al. Proteins, 2011 Oct. PMID 21905118.

    See all (75) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Study shows that HspB2 oligomers exchange subunits.
      Title: HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects.
    2. promoter methylation of heat shock protein B2 is a novel molecular biomarker in human esophageal squamous cell carcinoma
      Title: Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma.
    3. Reveal a novel function of HspB2 as an anti-apoptotic protein that negatively regulates apical caspase 3/8 activation in the extrinsic apoptotic pathway.
      Title: The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway.
    4. Hsp27, but not the classic Hsp60 and Hsp70, may be associated with the development bronchiolitis obliterans syndrome.
      Title: The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation.
    5. Sodium salicylate can induce the expression of HSP27 in human lens epithelial cells.
      Title: Effects of mitogen-activated protein kinase signal pathway on heat shock protein 27 expression in human lens epithelial cells exposed to sodium salicylate in vitro.
    6. Both heat and BPDE can induce the expressions of Hsp27 and Hsp70 in A549 cells.
      Title: [Effect of heat and BPDE on the expression of Hsp27 and Hsp70 in A549 cell line].
    7. analysis of CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients
      Title: CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients.
    8. HSP27 is linked to multi-drug resistance in cell line HepG2/VCR.
      Title: [Heat-shock protein 27 linked to multi-drug resistance in human hepatic cancer cell lines].
    9. The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with lymph node metastasis in colorectal cancer.
      Title: [Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer].
    10. 5-fluorouracil & carboplatin specifically induce expression of Hsp27 in hepatoma cells. siRNA knockdown of Hsp27 diminishes survival of drug-exposed cells.
      Title: Inhibition of Hsp27 and Hsp40 potentiates 5-fluorouracil and carboplatin mediated cell killing in hepatoma cells.
    Submit: New GeneRIF Correction See all (49)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q16082 Q9HAZ1 CLK4    HPRD  PubMed  
    Q16082 Q09013 DMPK    HPRD  PubMed  
    Q16082 Q12988 HSPB3    HPRD  PubMed  
    Q16082 O75582 RPS6KA5    HPRD  PubMed  
    BioGRID:109548 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:107799 CRYAA    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109548 BioGRID:107800 CRYAB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109548 BioGRID:107810 CRYGC    BioGRID  PubMed Two-hybrid 
    BioGRID:109548 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:108100 DMPK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109548 BioGRID:108292 EIF4E    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:109425 HNRNPD    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; FRET 
    BioGRID:109548 BioGRID:109530 HSF1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:109548 BioGRID:109548 HSPB2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109548 BioGRID:114470 HSPB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:117689 HSPB8    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109548 BioGRID:114120 MAPKAPK5    BioGRID  PubMed Biochemical Activity 
    BioGRID:109548 BioGRID:112506 SNCA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109548 BioGRID:112979 TNF    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:109548 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109548 BioGRID:121872 UBL5    BioGRID  PubMed Two-hybrid 
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...

    Markers

    Genotypes

    Readthrough HSPB2-C11orf52

    Readthrough gene: HSPB2-C11orf52, Included gene: C11orf52

    Homology

    Clone Names

    • MGC133245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    positive regulation of catalytic activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    somatic muscle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    heat shock protein beta-2
    Names
    heat shock protein beta-2
    DMPK-binding protein
    heat-shock protein beta-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033080.1 RefSeqGene

      Range
      5001..6358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001541.3 → NP_001532.1  heat shock protein beta-2

      Status: REVIEWED

      Source sequence(s)
      AB096250, AI131288
      Consensus CDS
      CCDS8352.1
      UniProtKB/TrEMBL
      A8KAH6
      UniProtKB/Swiss-Prot
      Q16082
      Conserved Domains (2) summary
      COG0071
      Location:53 – 148
      Blast Score: 107
      IbpA; Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]
      cd06476
      Location:67 – 148
      Blast Score: 398
      ACD_HspB2_like; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB2/heat shock 27kDa protein 2 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 PATCHES

    Genomic

    1. NW_003871080.1 Reference GRCh37.p10 PATCHES

      Range
      164727..166084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p10 Primary Assembly

      Range
      111783460..111784817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      107707366..107708777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018922.1 Alternate CHM1_1.0

      Range
      111646894..111648251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01039810.1 (75466..76165) None
    genomic ABBA01039811.1 None
    genomic AMYH01004032.1 (25978..27335) None
    genomic AP000907.6 (14391..15709) None
    genomic AY208910.1 AAO18081.1
    genomic CH471065.1 EAW67168.1
      EAW67169.1
    genomic EF444955.1 ACA05948.1
    genomic EF444984.1 ACA06000.1
    genomic U75898.1 AAB82757.1
    mRNA AB096250.1 None
    mRNA AI131288.1 None
    mRNA BC109393.1 AAI09394.1
    mRNA CR457408.1 CAG33689.1
    mRNA D89617.1 BAA24004.1
    mRNA S67070.1 AAB28816.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16082.2 GenPept UniProtKB/Swiss-Prot:Q16082

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
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      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
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      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
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        Link to related Nucleotide entry
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      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
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        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
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        Related SNP records
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        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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