My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    HSPB1 heat shock 27kDa protein 1 [ Homo sapiens ]

    Gene ID: 3315, updated on 20-May-2012
    Help top of page

    Summary

    Official Symbol
    HSPB1provided by HGNC
    Official Full Name
    heat shock 27kDa protein 1provided by HGNC
    Primary source
    HGNC:5246
    See related
    Ensembl:ENSG00000106211; HPRD:09076; MIM:602195; Vega:OTTHUMG00000023228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; DKFZp586P1322
    Summary
    The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]
    Help top of page

    Genomic context

    Location :
    7q11.23
    Sequence :
    Chromosome: 7; NC_000007.13 (75931875..75933614)
    See HSPB1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene GTF2I repeat domain containing 1 pseudogene Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Neighboring gene scavenger receptor cysteine rich domain containing, group B (4 domains) Neighboring gene zona pellucida glycoprotein 3 (sperm receptor)

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Martins-de-Souza D, et al. J Proteome Res, 2012 Apr 6. PMID 22360420.
    2. Sequence, structure, and dynamic determinants of Hsp27 (HspB1) equilibrium dissociation are encoded by the N-terminal domain. McDonald ET, et al. Biochemistry, 2012 Feb 14. PMID 22264079.
    3. Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. Gibert B, et al. PLoS One, 2012. PMID 22238643.
    4. Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses. Nagaraja GM, et al. Cancer Prev Res (Phila), 2012 Jan. PMID 22185976.
    5. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.

    See all (246) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.
      Title: Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.
    2. Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses
      Title: Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses.
    3. This first structural analysis of human small Hsp27 (HspB1) dissociation supports a model of chaperone activity wherein unstructured and highly flexible regions in the N-terminal domain are critical for substrate binding.
      Title: Sequence, structure, and dynamic determinants of Hsp27 (HspB1) equilibrium dissociation are encoded by the N-terminal domain.
    4. phosphorylated HSPB1 may play an important role in 5-FU resistance.
      Title: Identification of phosphorylated serine-15 and -82 residues of HSPB1 in 5-fluorouracil-resistant colorectal cancer cells by proteomics.
    5. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    6. Studied three Hsp27 truncation variants to assess the functional contributions of the nonconserved N- and C-terminal sequences.
      Title: Roles of the N- and C-terminal sequences in Hsp27 self-association and chaperone activity.
    7. The CG/GG genotypes of HSPB1 rs2868371 were associated with lower risk of RIET, compared with the CC genotype in patients with NSCLC treated with radio(chemo)therapy.
      Title: Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy.
    8. We studied the HSPB1 and HSPB8 mutation occurrence in patients with distal hereditary motor neuropathy and those with the axonal form of Charcot-Marie-Tooth disease type 2
      Title: HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients.
    9. In this review, we will focus on the possible protective and immuno-modulatory roles of Hsp27 in atherogenesis with special emphasis on their changes following acute coronary events and their potential as diagnostic and therapeutic targets
      Title: The potential role of heat shock protein 27 in cardiovascular disease.
    10. provide evidence for elevated HSP27 concentrations in serum and urine and increased HSP70 excretion levels in patients suffering from CKD
      Title: HSP27 and HSP70 serum and urine levels in patients suffering from chronic kidney disease.
    Submit: New GeneRIF Correction See all (173)
    Help top of page

    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Charcot-Marie-Tooth disease, axonal, type 2F

    Neuropathy, distal hereditary motor, type IIB

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001531.1 NP_055180.1 HSPB8    BIND  PubMed HSP22 interacts with HSP27. 
    NP_001531.1 MAPKAPK2    BIND  PubMed MK2 phosphorylates Hsp27. This interaction was modelled on a demonstrated interaction between human MK2 and Hsp27 from an unspecified species. 
    NP_001531.1 NP_005828.1 POP7    BIND  PubMed Rpp20 interacts with Hsp27 
    P04792 P68032 ACTC1    HPRD  PubMed  
    P04792 P02489 CRYAA    HPRD  PubMed  
    P04792 P02511 CRYAB    HPRD  PubMed  
    P04792 P43320 CRYBB2    HPRD  PubMed  
    P04792 P07315 CRYGC    HPRD  PubMed  
    P04792 P99999 CYCS    HPRD  PubMed  
    P04792 Q9UER7 DAXX    HPRD  PubMed  
    P04792 Q04637 EIF4G1    HPRD  PubMed  
    P04792 Q9UJY1 HSPB8    HPRD  PubMed  
    P04792 Q96ID5 IGSF21    HPRD  PubMed  
    P04792 Q5T3J3 LRIF1    HPRD  PubMed  
    P04792 P49137 MAPKAPK2    HPRD  PubMed  
    P04792 Q16644 MAPKAPK3    HPRD  PubMed  
    P04792 Q8IW41 MAPKAPK5    HPRD  PubMed  
    P04792 Q9Y3C7 MED31    HPRD  PubMed  
    P04792 P25963 NFKBIA    HPRD  PubMed  
    P04792 O75817 POP7    HPRD  PubMed  
    P04792 Q15181 PPA1    HPRD  PubMed  
    P04792 Hypothetical protein DKFZp564O0523 RBM48    HPRD  PubMed  
    P04792 HIC5 TGFB1I1    HPRD  PubMed  
    P04792 P22735 TGM1    HPRD  PubMed  
    P04792 P04637 TP53    HPRD  PubMed  
    BioGRID:109547 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:107286 CASP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:107799 CRYAA    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109547 BioGRID:107800 CRYAB    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:109547 BioGRID:107805 CRYBB2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109547 BioGRID:119922 CYCS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:108102 DMWD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:108814 G6PD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:108893 GATA1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:109547 BioGRID:115330 HDAC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:109425 HNRNPD    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; FRET 
    BioGRID:109547 BioGRID:109530 HSF1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:109547 BioGRID:117689 HSPB8    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109547 BioGRID:124396 IGSF21    BioGRID  PubMed Two-hybrid 
    BioGRID:109547 BioGRID:109824 ILK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:109547 BioGRID:114879 MAGED1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:114683 MAPKAPK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:114120 MAPKAPK5    BioGRID  PubMed Biochemical Activity 
    BioGRID:109547 BioGRID:119211 MED31    BioGRID  PubMed Two-hybrid 
    BioGRID:109547 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109547 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:111460 PPA1    BioGRID  PubMed Two-hybrid 
    BioGRID:109547 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:111573 PRKD1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:109547 BioGRID:123855 RBM48    BioGRID  PubMed Two-hybrid 
    BioGRID:109547 BioGRID:114676 RPS6KA5    BioGRID  PubMed Biochemical Activity 
    BioGRID:109547 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:112650 STAT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109547 BioGRID:112899 TGFB1I1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109547 BioGRID:112979 TNF    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:109547 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109547 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:109547 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109547 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109547 BioGRID:113220 UNG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109547 BioGRID:113241 USP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:124165 USP38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109547 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystem (from REACTOME)
      Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystemAUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elements (AREs) in the 3' untranslated regions of mRNAs. The binding causes AUF1 dimers to assemble into higher order tetrameric complexes. Dipho...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem (from REACTOME)
      Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
      Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
      Signaling mediated by p38-alpha and p38-beta
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
    • p38 signaling mediated by MAPKAP kinases, organism-specific biosystem (from Pathway Interaction Database)
      p38 signaling mediated by MAPKAP kinases, organism-specific biosystem
      p38 signaling mediated by MAPKAP kinases

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein kinase C delta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase C inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    RNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular component movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    mRNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of tumor necrosis factor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of I-kappaB kinase/NF-kappaB cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contractile fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    insoluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    heat shock protein beta-1
    Names
    heat shock protein beta-1
    HSP 27
    28 kDa heat shock protein
    heat shock 27 kDa protein
    heat shock 27kD protein 1
    stress-responsive protein 27
    estrogen-regulated 24 kDa protein
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008995.1 RefSeqGene

      Range
      5001..6740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001540.3 → NP_001531.1  heat shock protein beta-1

      Status: REVIEWED

      Source sequence(s)
      BC012768, BP231480
      Consensus CDS
      CCDS5583.1
      UniProtKB/Swiss-Prot
      P04792
      Related
      ENSP00000248553, OTTHUMP00000161096, ENST00000248553, OTTHUMT00000252958
      Conserved Domains (1) summary
      cd06475
      Location:84 – 169
      Blast Score: 444
      ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      75931875..75933614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      71018196..71019935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      75264939..75266678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006388.3 (47482..49171) None
    genomic CH471220.1 EAW71803.1
    genomic DQ379985.1 ABC88475.1
    genomic L39370.1 AAA62175.1
    mRNA AB020027.1 BAB17232.1
    mRNA AK296890.1 BAG59449.1
    mRNA AK311446.1 None
    mRNA AK311894.1 BAG34835.1
    mRNA AL050380.1 None
    mRNA BC000510.2 AAH00510.1
    mRNA BC012292.1 AAH12292.1
    mRNA BC012768.2 AAH12768.1
    mRNA BC014920.1 AAH14920.1
    mRNA BC073768.1 AAH73768.1
    mRNA BP231480.1 None
    mRNA BT019888.1 AAV38691.1
    mRNA CR407614.1 CAG28542.1
    mRNA CR536489.1 CAG38728.1
    mRNA S74571.1 AAB20722.1
    mRNA U90906.1 AAB51056.1
    mRNA X16477.1 CAA34498.1
    mRNA X54079.1 CAA38016.1
    other-genetic DQ891304.2 ABM82230.1
    other-genetic DQ893349.2 ABM84275.1
    other-genetic DQ894489.2 ABM85415.1
    other-genetic DQ896669.2 ABM87668.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04792.2 GenPept UniProtKB/Swiss-Prot:P04792
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...