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    slgA sluggish A [ Drosophila melanogaster ]

    Gene ID: 33117, updated on 25-May-2012
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    Summary

    Official Symbol
    slgAprovided by Flybase
    Official Full Name
    sluggish Aprovided by Flybase
    Primary source
    FLYBASE:FBgn0003423
    Locus tag
    Dmel_CG1417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1417; Dmel\CG1417; EE85; PRODH; sl; slg; tu3
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    Genomic context

    Location :
    19F6-20A1
    Sequence :
    Chromosome: X; NC_004354.3 (21245018..21256188)
    See slgA in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene Septin-1 Neighboring gene waclaw Neighboring gene ncRNA Neighboring gene Helicase Neighboring gene misato

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047.
    2. Neuropathology in Drosophila mutants with increased seizure susceptibility. Fergestad T, et al. Genetics, 2008 Feb. PMID 18245348.
    3. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    4. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    5. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Choksi SP, et al. Dev Cell, 2006 Dec. PMID 17141154.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:59392 BioGRID:63061 CG10069    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:67072 CG10326    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:62121 CG13159    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:66660 CG14391    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:64135 CG32406    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:59866 CG3294    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:57960 CG3309    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:60729 CG5792    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:69539 Ef1beta    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:57914 HLH4C    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:61474 Mob4    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:66080 Mst84Da    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:78249 RpL5    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:60502 RpS27A    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:57608 TRAM    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:66459 Tpc1    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:60980 cact    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:59332 cactin    BioGRID  PubMed Two-hybrid 
    BioGRID:59392 BioGRID:63427 eIF-5A    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Homology

    • Homologs of the slgA gene: The slgA gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    proline dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    proline dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    glutamate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    glutamate biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		  
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    proline catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    proline catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    proline catabolic process NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG1417 gene product from transcript CG1417-RJ
    Names
    CG1417-PA
    CG1417-PB
    CG1417-PC
    CG1417-PD
    CG1417-PE
    CG1417-PF
    CG1417-PG
    CG1417-PH
    CG1417-PI
    CG1417-PJ
    CG1417-PK
    CG1417-PL
    CG1417-PM
    CG1417-PN
    proline dehydrogenase
    slgA-PA
    slgA-PB
    slgA-PC
    slgA-PD
    slgA-PE
    slgA-PF
    slgA-PG
    slgA-PH
    slgA-PI
    slgA-PJ
    slgA-PK
    slgA-PL
    slgA-PM
    slgA-PN
    sluggish
    sluggish A
    sluggish-A
    sluggishA
    NP_001245791.1
    NP_001245792.1
    NP_001245793.1
    NP_001245794.1
    NP_001245795.1
    NP_001245796.1
    NP_523433.2
    NP_728422.1
    NP_728423.1
    NP_728424.1
    NP_728425.1
    NP_996526.1
    NP_996527.1
    NP_996528.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      21245018..21256188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258863.1 → NP_001245792.1  sluggish A, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 985
      Pro_dh; Proline dehydrogenase

    2. NM_206803.2 → NP_996526.1  sluggish A, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0089306
      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 985
      Pro_dh; Proline dehydrogenase

    3. NM_078709.3 → NP_523433.2  sluggish A, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0076904
      Conserved Domains (1) summary
      cl03282
      Location:307 – 646
      Blast Score: 973
      Pro_dh; Proline dehydrogenase

    4. NM_167752.2 → NP_728423.1  sluggish A, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0076903
      Conserved Domains (1) summary
      cl03282
      Location:307 – 646
      Blast Score: 971
      Pro_dh; Proline dehydrogenase

    5. NM_167753.2 → NP_728424.1  sluggish A, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0076905
      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 983
      Pro_dh; Proline dehydrogenase

    6. NM_001258862.1 → NP_001245791.1  sluggish A, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 983
      Pro_dh; Proline dehydrogenase

    7. NM_206805.2 → NP_996528.1  sluggish A, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0089304
      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 985
      Pro_dh; Proline dehydrogenase

    8. NM_167751.2 → NP_728422.1  sluggish A, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0076902
      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 985
      Pro_dh; Proline dehydrogenase

    9. NM_001258864.1 → NP_001245793.1  sluggish A, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 985
      Pro_dh; Proline dehydrogenase

    10. NM_001258867.1 → NP_001245796.1  sluggish A, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl03282
      Location:307 – 646
      Blast Score: 973
      Pro_dh; Proline dehydrogenase

    11. NM_206804.2 → NP_996527.1  sluggish A, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V4U5
      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0089305
      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 985
      Pro_dh; Proline dehydrogenase

    12. NM_001258866.1 → NP_001245795.1  sluggish A, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 983
      Pro_dh; Proline dehydrogenase

    13. NM_001258865.1 → NP_001245794.1  sluggish A, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl03282
      Location:290 – 634
      Blast Score: 985
      Pro_dh; Proline dehydrogenase

    14. NM_167754.1 → NP_728425.1  sluggish A, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04499
      Related
      FBpp0076906, FBtr0077207
      Conserved Domains (1) summary
      cl03282
      Location:7 – 321
      Blast Score: 922
      Pro_dh; Proline dehydrogenase
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 AFH07504.1
    genomic AE014298.4 AAF50821.1
    genomic AE014298.4 AAS65415.1
    genomic AE014298.4 AFH07506.1
    genomic AE014298.4 AFH07505.1
    genomic HH769100.1 CBX85281.1
    mRNA AY069407.1 AAL39552.1
    genomic AE014298.4 AAS65413.1
    genomic AE014298.4 AAS65414.1
    genomic AE014298.4 AAF50814.2
    genomic HH769078.1 CBX85270.1
    genomic AE014298.4 AFH07508.1
    genomic HH769212.1 CBX85337.1
    genomic AE014298.4 AAF50822.3
    genomic AE014298.4 AFH07503.1
    genomic AE014298.4 AAF50820.2
    genomic HH769084.1 CBX85273.1
    genomic AE014298.4 AFH07507.1
    genomic HH769086.1 CBX85274.1
    genomic AE014298.4 AAF50819.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAF50822.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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