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Arhgap32 Rho GTPase activating protein 32 [ Mus musculus (house mouse) ]

Gene ID: 330914, updated on 8-May-2016
Official Symbol
Arhgap32provided by MGI
Official Full Name
Rho GTPase activating protein 32provided by MGI
Primary source
MGI:MGI:2450166
See related
Ensembl:ENSMUSG00000041444 Vega:OTTMUSG00000036900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grit; Rics; Gc-gap; Px-rics; p250Gap; mKIAA0712; p200Rhogap; 3426406O18Rik
Annotation information
Note: There are conflicting opinions about the protein-coding potential of this locus. [17 Jun 2011]
Orthologs
Location:
9; 9 A4
Exon count:
26
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (32016882..32268443)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (31923721..32072084)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene triosephosphate isomerase related sequence 4 Neighboring gene predicted gene, 31669 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene predicted gene, 39317

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0712

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho GTPase-activating protein 32
Names
GAB-associated CDC42
GAB-associated Cdc42/Rac GTPase-activating protein
GTPase-activating protein for Cdc42 and Rac1
Rho GTPase activating protein 33 pseudogene
brain-specific Rho GTPase-activating protein
rac GTPase activating protein
rho-type GTPase-activating protein 32
rho/Cdc42/Rac GTPase-activating protein RICS
rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195632.1NP_001182561.1  rho GTPase-activating protein 32 isoform 1

    See identical proteins and their annotated locations for NP_001182561.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as PX-RICS). This variant lacks full-length transcript support in mouse, with the 5' exon structure being inferred from homologous transcript alignments. Evidence in the literature, including that in PMIDs 17663722, 16716191, 12857875 and 12531901, support the existence of this longer isoform in mouse.
    Source sequence(s)
    AC132114, AC134607, AY194286, CN669722
    Consensus CDS
    CCDS57666.1
    UniProtKB/Swiss-Prot
    Q811P8
    Related
    ENSMUSP00000133898, OTTMUSP00000052829, ENSMUST00000174641, OTTMUST00000094795
    Conserved Domains (3) summary
    cd07298
    Location:127241
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:263316
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:368562
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  2. NM_177379.4NP_796353.3  rho GTPase-activating protein 32 isoform 2

    See identical proteins and their annotated locations for NP_796353.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2, also known as RICS) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC132114, BC132390, BF456362, BY287051, CN669722
    Consensus CDS
    CCDS22951.3
    UniProtKB/Swiss-Prot
    Q811P8
    Related
    ENSMUSP00000128448, OTTMUSP00000052831, ENSMUST00000168954, OTTMUST00000094797
    Conserved Domains (1) summary
    cd04384
    Location:19213
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    32016882..32268443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510445.2XP_006510508.1  

    See identical proteins and their annotated locations for XP_006510508.1

    Conserved Domains (3) summary
    cd07298
    Location:101215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342536
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  2. XM_011242560.1XP_011240862.1  

    See identical proteins and their annotated locations for XP_011240862.1

    Conserved Domains (3) summary
    cd07298
    Location:101215
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:237290
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:342536
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
  3. XM_006510442.2XP_006510505.1  

    Conserved Domains (3) summary
    cd07298
    Location:141255
    PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
    cd11835
    Location:277330
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:382576
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    29377749..29527501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_020962.1: Suppressed sequence

    Description
    NG_020962.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.