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    Mer Merlin [ Drosophila melanogaster ]

    Gene ID: 32979, updated on 10-May-2012
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    Summary

    Official Symbol
    Merprovided by Flybase
    Official Full Name
    Merlinprovided by Flybase
    Primary source
    FLYBASE:FBgn0086384
    Locus tag
    Dmel_CG14228
    Gene type
    protein coding
    RNA name
    merlin
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG01543; CG14228; D-Mer; Dmel\CG14228; Dmerlin; Emr2; EMR2; mer
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    Genomic context

    Location :
    18E1-18E1
    Sequence :
    Chromosome: X; NC_004354.3 (19584627..19587531, complement)
    See Mer in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene Ubiquilin Neighboring gene CG14227 gene product from transcript CG14227-RB Neighboring gene CG14229 gene product from transcript CG14229-RA Neighboring gene CG12530 gene product from transcript CG12530-RC Neighboring gene CG14231 gene product from transcript CG14231-RB

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila. Yang Y, et al. Dev Biol, 2012 Jan 15. PMID 22133918.
    2. Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate. Jukam D, et al. Dev Cell, 2011 Nov 15. PMID 22055343.
    3. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. Sansores-Garcia L, et al. EMBO J, 2011 May 10. PMID 21556047.
    4. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Fernández BG, et al. Development, 2011 Jun. PMID 21525075.
    5. [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation]. Bolobolova EU, et al. Tsitologiia, 2011. PMID 21473116.

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Drosophila melanogaster protein phosphatase type 1 beta (flapwing) co-regulates dephosphorylation and altered activity of both Merlin and Moesin.
      Title: The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.
    2. The result reveals role for merlin in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.
      Title: Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate.
    3. Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation
      Title: [Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation].
    4. The role of the functional sites of the Merlin tumor suppressor in Drosophila spermatogenesis
      Title: [The role of the functional sites of the Merlin tumor suppressor in Drosophila spermatogenesis].
    5. Data demonstrate that Cdc42 and Merlin act together with Pak1 to control salivary gland lumen size.
      Title: Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape.
    6. the Merlin and Lap proteins colocalized at the cortex of the wing imaginal disc cells.
      Title: [Drosophila melanogaster gene Merlin interacts with the clathrin adaptor protein gene lap].
    7. microtubule-dependent transport is critical for Merlin function
      Title: Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants.
    8. Merlin mutation leads to depression of vein clonal restriction property. This means that this gene is involved not only in the control of cell proliferation, but also in the control of cell mobility and adhesion.
      Title: [Effect of mutations in Drosophila melanogaster tumor suppressor Merlin on proliferation and differentiation of wing cells].
    9. Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin
      Title: [Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin].
    10. Kibra functions together with Mer and Ex in a protein complex localized to the apical domain of epithelial cells, and this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav.
      Title: Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.
    Submit: New GeneRIF Correction See all (17)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:59275 BioGRID:68655 ATPsyn-beta    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:71866 Atpalpha    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58653 Bap60    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61428 BubR1    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64185 CG10147    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62410 CG10249    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61107 CG10333    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:63020 CG10543    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:57633 CG11398    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58732 CG11581    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68306 CG11873    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60557 CG12299    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65192 CG13022    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60303 CG13096    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:57687 CG14815    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:59844 CG15438    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62243 CG17050    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67353 CG17186    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65484 CG17233    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58397 CG17841    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64527 CG18178    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61851 CG18446    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66531 CG18476    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:59491 CG2807    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65882 CG2926    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61575 CG30492    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67246 CG31224    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61154 CG31792    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67933 CG33095    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:624807 CG34340    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:57605 CG3711    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65339 CG3902    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58006 CG42699    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67352 CG4562    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65128 CG4877    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67379 CG4936    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:59559 CG5001    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60748 CG5439    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65264 CG5589    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60172 CG6441    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66519 CG6791    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66545 CG6923    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:59208 CG7556    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60274 CG7627    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66197 CG8021    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62062 CG8290    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65417 CG8765    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62031 CG9005    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60737 CG9934    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:1455422 CR42862    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58260 Caf1-180    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61805 Camta    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64241 Cdc27    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68567 CycG    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64171 D19A    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64049 Dhc64C    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62139 Dyb    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62026 E(Pc)    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:70621 Exp6    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58836 Gmap    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:59989 Gpdh    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:57914 HLH4C    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62453 Khc-73    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:74442 Liprin-alpha    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58792 Lsd-2    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:63832 MEP-1    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:71956 Mbs    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67259 Mekk1    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:59275 Mer    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67007 Mhcl    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:57852 Mnt    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58274 Moe    BioGRID  PubMed Co-localization; Two-hybrid 
    BioGRID:59275 BioGRID:67630 Nup133    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68832 Patj    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:57689 Pgam5    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66344 Pnn    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64121 Pole2    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58049 Rbcn-3A    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68653 Rfabg    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:63973 Rop    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:57590 RpL22    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64500 RpS9    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68823 Rs1    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67787 SMC1    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64841 SNCF    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:70124 Spn    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68428 Sry-delta    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:77919 Unc-89    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60135 ade3    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66045 alphaTub84B    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:534267 bbx    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62900 betaTub56D    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68626 bip2    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:63464 bs    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59275 BioGRID:60980 cact    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67287 cdi    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62418 chn    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68877 chrw    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62870 cora    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60909 dao    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:59659 dpp    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59275 BioGRID:59474 ex    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59275 BioGRID:69303 for    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60297 fu2    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60293 grk    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:59275 BioGRID:62421 igl    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66857 kibra    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:70092 l(2)08717    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66850 l(3)L1231    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60002 lid    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61606 lin19    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:62257 mars    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68602 mod    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66996 mor    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:63677 mwh    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:69604 net    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:59275 BioGRID:67026 pad    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58105 pod1    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:67879 polybromo    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:60680 prd    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:58797 rab3-GEF    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64387 rhea    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:76064 sav    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:68787 sbb    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:59275 BioGRID:60924 sna    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:65697 srpk79D    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:64836 trn    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:61941 wde    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:66738 yrt    BioGRID  PubMed Two-hybrid 
    BioGRID:59275 BioGRID:77850 zormin    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeletal protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle arrest IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    cell-cell signaling IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		  
    compound eye photoreceptor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    decapentaplegic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    endocytic recycling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    endocytosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    hippo signaling cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    pole plasm mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    regulation of cell growth IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of compound eye retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Nebenkern IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    extrinsic to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG14228 gene product from transcript CG14228-RA
    Names
    BG01543
    CG14228-PA
    D merlin
    Ezrin-moesin-radixin-2
    Mer-PA
    Merlin/Neurofibromin 2
    dmerlin
    merlin
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      19584627..19587531, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078689.3 → NP_523413.1  merlin [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24564
      Related
      FBpp0074523, FBtr0074754
      Conserved Domains (5) summary
      pfam00769
      Location:341 – 635
      Blast Score: 466
      ERM; Ezrin/radixin/moesin family
      cd00836
      Location:210 – 302
      Blast Score: 243
      FERM_C; FERM_C domain
      smart00295
      Location:14 – 216
      Blast Score: 444
      B41; Band 4.1 homologues
      pfam00373
      Location:103 – 216
      Blast Score: 239
      FERM_M; FERM central domain
      pfam09379
      Location:20 – 96
      Blast Score: 186
      FERM_N; FERM N-terminal domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 AAF49005.1
    mRNA U49724.1 AAB08449.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24564.1 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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