U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG8028 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32923, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
CG8028provided by FlyBase
Primary source
FLYBASE:FBgn0031010
Locus tag
Dmel_CG8028
See related
AllianceGenome:FB:FBgn0031010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8028; MCT
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be integral component of membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in cataract 47 and familial hyperinsulinemic hypoglycemia 7. Orthologous to several human genes including SLC16A1 (solute carrier family 16 member 1); SLC16A12 (solute carrier family 16 member 12); and SLC16A3 (solute carrier family 16 member 3). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG8028 in Genome Data Viewer
Location:
18B8-18B9; 1-62 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19277176..19280349, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19171209..19174382, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vav guanine nucleotide exchange factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 763 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules of Drosophila melanogaster larvae. Chahine S, et al. Arch Insect Biochem Physiol, 2010 Mar. PMID 20077573
  2. Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster. Chahine S, et al. J Insect Physiol, 2009 Oct. PMID 19545574
  3. A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions. Yurgel ME, et al. PLoS Biol, 2019 Feb. PMID 30759083, Free PMC Article
  4. Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. Volkenhoff A, et al. Cell Metab, 2015 Sep 1. PMID 26235423
  5. Updates on ion and water transport by the Malpighian tubule. Dow JAT, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33705976, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in renal tubular secretion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG8028-PC
CG8028-PD
monocarboxylate transporter

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19277176..19280349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103561.2 → NP_001097031.2  uncharacterized protein Dmel_CG8028, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097031.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUR0
    Conserved Domains (1) summary
    cd06174
    Location:40 → 215
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_133147.2 → NP_573375.2  uncharacterized protein Dmel_CG8028, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573375.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWJ2
    Conserved Domains (2) summary
    cd06174
    Location:1 → 138
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:1 → 160
    MFS_1; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JUR0 A8JUR0
Q6AWN8 Q6AWN8
Q9VWJ2 Q9VWJ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases