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    BIRC2 baculoviral IAP repeat containing 2 [ Homo sapiens ]

    Gene ID: 329, updated on 11-Feb-2012
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    Summary

    Official Symbol
    BIRC2provided by HGNC
    Official Full Name
    baculoviral IAP repeat containing 2provided by HGNC
    Primary source
    HGNC:590
    See related
    Ensembl:ENSG00000110330; HPRD:03419; MIM:601712; Vega:OTTHUMG00000167325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
    Summary
    The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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    Genomic context

    Location :
    11q22
    Sequence :
    Chromosome: 11; NC_000011.9 (102217966..102249401)
    See BIRC2 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene 17 Neighboring gene baculoviral IAP repeat containing 3 Neighboring gene transmembrane protein 123 Neighboring gene uncharacterized LOC727869 Neighboring gene matrix metallopeptidase 7 (matrilysin, uterine)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of F-box only protein 7 as a negative regulator of NF-kappaB signaling. Kuiken HJ, et al. J Cell Mol Med, 2012 Jan 2. PMID 22212761.
    2. Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Dueber EC, et al. Science, 2011 Oct 21. PMID 22021857.
    3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    4. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). Bertrand MJ, et al. PLoS One, 2011. PMID 21931591.
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.

    See all (134) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. cIAP1 and cIAP2 are direct E3 ubiquitin ligases for all four RIP proteins
      Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
    2. The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
      Title: The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
    3. Data show that inhibitor-induced rapid degradation of cIAPs requires binding to TRAF2, and reveal an unexpected difference between cIAP1 and cIAP2.
      Title: Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
    4. cIAP1/2 are important regulators of inflammatory processes in endothelial cells.
      Title: Inhibitor of apoptosis proteins as novel targets in inflammatory processes.
    5. one of the functions of cIAP1 when localized in the nucleus is to regulate E2F1 transcriptional activity.
      Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.
    6. The structure of the caspase recruitment domain (CARD) of cIAP1 is required for cIAP1 autoregulation.
      Title: CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.
    7. Data show that NIPER-4 induces cIAP1-mediated ubiquitylation of CRABP-II, resulting in the proteasomal degradation.
      Title: Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.
    8. Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization
      Title: Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.
    9. The authors demonstrate that c-IAP1 and UbcH5 family promote K11-linked polyubiquitination of receptor-interacting protein 1 (RIP1) in vitro and in vivo.
      Title: c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
    10. IAPs could be involved in prostate disorder (BPH, PIN and PC) development since might be provoke inhibition of apoptosis and subsequently cell proliferation
      Title: Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate.
    Submit: New GeneRIF Correction See all (70)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr-(52-96)-induced apoptosis is mediated through downregulation of Bcl2 and c-IAP1 genes PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001157.1 CASP7    BIND  PubMed c-IAP1 interacts with caspase-7. 
    NP_001157.1 NP_002333.1 LTBR    BIND  PubMed cIAP1 interacts with LTBR. 
    NP_001157.1 NP_005649.1 TRAF1    BIND  PubMed c-IAP1 interacts with TRAF1. 
    NP_001157.1 NP_066961.2 TRAF2    BIND  PubMed c-IAP1 interacts with and ubiquitinates TRAF2. 
    NP_001157.1 NP_057105.2 UBE2J1    BIND  PubMed UBE2J1 (hUbc6e), an E2 ubiquitin-conjugating enzyme, interacts with and assists autoubiquitination of BIRC2 (c-IAP1), an E3 ubiquitin-protein ligase. 
    NP_001157.1     BIND  PubMed Biotinylated compound 3 interacts with IAP 1. 
    Q13490 P42574 CASP3    HPRD  PubMed  
    Q13490 P55210 CASP7    HPRD  PubMed  
    Q13490 P55211 CASP9    HPRD  PubMed  
    Q13490 P25942 CD40    HPRD  PubMed  
    Q13490 Q9NR28 DIABLO    HPRD  PubMed  
    Q13490 P15170 GSPT1    HPRD  PubMed  
    Q13490 O43464 HTRA2    HPRD  PubMed  
    Q13490 Q13077 TRAF1    HPRD  PubMed  
    Q13490 Q12933 TRAF2    HPRD  PubMed  
    BioGRID:106826 BioGRID:116235 ADRM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:114429 BCL10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:106826 BIRC2    BioGRID  PubMed Biochemical Activity; Co-crystal Structure; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:106826 BioGRID:106829 BIRC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106826 BioGRID:122670 BIRC7    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:106826 BioGRID:107290 CASP7    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:106826 BioGRID:107291 CASP8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:107292 CASP9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106826 BioGRID:121157 DIABLO    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106826 BioGRID:117326 FBXO7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:109190 GSPT1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106826 BioGRID:113036 HSP90B1    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:106826 BioGRID:118165 HTRA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106826 BioGRID:114089 IKBKG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:109931 JUP    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:110284 MAGEA11    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:114487 MAP3K14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:121570 MAVS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:111831 RAF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106826 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106826 BioGRID:114300 RIPK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106826 BioGRID:116224 RIPK3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106826 BioGRID:119899 RIPK4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106826 BioGRID:115328 TANK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106826 BioGRID:112979 TNF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106826 BioGRID:119478 TNFRSF12A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:114277 TNFSF14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106826 BioGRID:119978 TOLLIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106826 BioGRID:113037 TRAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106826 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:106826 BioGRID:113039 TRAF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:116608 TRIM32    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:113102 TSG101    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106826 BioGRID:113168 UBE2B    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:113169 UBE2D1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106826 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:113171 UBE2D3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106826 BioGRID:119555 UBE2J1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106826 BioGRID:113180 UBE2L3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:124986 UBE2Q2    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:118150 UBE2S    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:106826 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106826 BioGRID:116078 USP19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:120121 XAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106826 BioGRID:106828 XIAP    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
      CD40/CD40L signaling, organism-specific biosystem
      CD40/CD40L signaling
    • Canonical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical NF-kappaB pathway, organism-specific biosystem
      Canonical NF-kappaB pathway
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
      NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TNF receptor signaling pathway, organism-specific biosystem
      TNF receptor signaling pathway
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NIK/NF-kappaB cascade TAS
    Traceable Author Statement
    more info
    		  
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		  
    placenta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of RIG-I signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    		  
    regulation of innate immune response TAS
    Traceable Author Statement
    more info
    		  
    regulation of nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    regulation of toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    internal side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 2
    Names
    baculoviral IAP repeat-containing protein 2
    IAP-2
    IAP homolog B
    apoptosis inhibitor 1
    RING finger protein 48
    inhibitor of apoptosis protein 2
    baculoviral IAP repeat-containing 2
    NFR2-TRAF signalling complex protein
    TNFR2-TRAF-signaling complex protein 2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166.3 → NP_001157.1  baculoviral IAP repeat-containing protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC028578, BX647978
      Consensus CDS
      CCDS8316.1
      UniProtKB/Swiss-Prot
      Q13490
      Related
      ENSP00000227758, OTTHUMP00000235706, ENST00000227758, OTTHUMT00000394170
      Conserved Domains (3) summary
      cd00022
      Location:270 – 336
      Blast Score: 280
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:455 – 544
      Blast Score: 441
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cl15348
      Location:570 – 612
      Blast Score: 167
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      102217966..102249401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      98144543..98175923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP000942.6 (122577..154012) None
    genomic CH471065.1 EAW67018.1
    genomic DQ068066.1 AAY46158.1
    mRNA AK225856.1 None
    mRNA AK303197.1 BAG64288.1
    mRNA AK313446.1 BAG36235.1
    mRNA BC016174.1 AAH16174.1
    mRNA BC028578.1 AAH28578.1
    mRNA BX647978.1 None
    mRNA L49431.1 AAC41942.1
    mRNA U37547.1 AAC50508.1
    mRNA U45879.1 AAC50372.1
    other-genetic DQ892384.2 ABM83310.1
    other-genetic DQ895596.2 ABM86522.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q13490.2 GenPept UniProtKB/Swiss-Prot:Q13490
    Q8IZZ0 GenPept UniProtKB/TrEMBL:Q8IZZ0
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

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