APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: APEX1provided by HGNC
Official Full Name: APEX nuclease (multifunctional DNA repair enzyme) 1provided by HGNC
Primary source: HGNC:587
See related: Ensembl:ENSG00000100823; HPRD:00136; MIM:107748; Vega:OTTHUMG00000029544
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: APE; APX; APE1; APEN; APEX; HAP1; REF1
Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 14q11.2

Sequence :: Chromosome: 14; NC_000014.8 (20923290..20925931)

See APEX1 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that inhibiting APE1 repair endonuclease function in cancer cells is a promising strategy to overcome therapeutic agent resistance.
Title: Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.
APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
Title: APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
Elevated levels of CXCL1 and CXCL10 could possibly be used as a marker of inflammation and angiogenesis/angiostasis in type 2 diabetes
Title: Association of the polymorphism of APE1 gene with the risk of prostate cancer in Chinese Han population.
OGG1 Ser326Cys show an increased lung cancer risk in Asians and non-smokers; APEX1 Asp148Glu polymorphism may be associated with decreased lung adenocarcinoma risk, and APEX1 Asp148Glu polymorphism show an increased lung cancer risk in Asians and smokers
Title: Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis.
These results highlight the emerging role of acetylation of critical Lys residues in regulating APE1 functions.
Title: Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.
A functional footprinting approach was used to define the binding site of APE1 used for the repair of deaminated purines.
Title: Defining the functional footprint for recognition and repair of deaminated DNA.
These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.
Title: The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.
APE1 is a new coactivator of NRF1, demonstrating an additional regulatory role of APE1 in maintenance of mitochondrial functionality.
Title: Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1.
these findings reveal a profound deregulation of APE1 acetylation status in triple negative breast cancers, opening new perspectives for future improvements on treatment and prognosis of this molecular subtype of breast carcinomas.
Title: Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers.
We, for the first time, demonstrated the positive association of APE1, XRCC1, and XRCC3 DNA repair gene variants with Parkinson's disease risk.
Title: DNA repair genes in Parkinson's disease.

Submit: New GeneRIF Correction See all (229)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Rev, p19	rev	HIV-1 Rev interacting protein, APEX nuclease 1 (APEX1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with APEX1 is increased by RRE	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001632.2	NC_000006.9	CDKN1A	BIND	PubMed	Ref1 interacts weakly with p21 promoter.
NP_001632.2	AAH03178.1	MUTYH	BIND	PubMed	hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1)
NP_001632.2	NP_000537.2	TP53	BIND	PubMed	p53 interacts with Ref-1.
P27695	P39687	ANP32A	HPRD	PubMed
P27695	O43423	ANP32C	HPRD	PubMed
P27695	P27695	APEX1	HPRD	PubMed
P27695	P68400	CSNK2A1	HPRD	PubMed
P27695	Q14203	DCTN1	HPRD	PubMed
P27695	Q09472	EP300	HPRD	PubMed
P27695	P39748	FEN1	HPRD	PubMed
P27695	P12544	GZMA	HPRD	PubMed
P27695	Q13547	HDAC1	HPRD	PubMed
P27695	Q16665	HIF1A	HPRD	PubMed
P27695	P26583	HMGB2	HPRD	PubMed
P27695	P14866	HNRNPL	HPRD	PubMed
P27695	Heat shock 70 KD protein 1A	HSPA1A	HPRD	PubMed
P27695	Q9UIF7	MUTYH	HPRD	PubMed
P27695	P15531	NME1	HPRD	PubMed
P27695	Q9GZY0	NXF2	HPRD	PubMed
P27695	P12004	PCNA	HPRD	PubMed
P27695	P06746	POLB	HPRD	PubMed
P27695	Q01105	SET	HPRD	PubMed
P27695	P04637	TP53	HPRD	PubMed
P27695	P10599	TXN	HPRD	PubMed
P27695	P63279	UBE2I	HPRD	PubMed
P27695	P18887	XRCC1	HPRD	PubMed
P27695	P12956	XRCC6	HPRD	PubMed
BioGRID:106825	BioGRID:113791	ANP32A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:106825	BioGRID:115694	ARIH2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:106922	ASCL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:107276	CAPNS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:125411	CCDC124	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106825	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:108528	FEN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106825	BioGRID:1777030	HHV8GK18_gp81	BioGRID	PubMed	Far Western
BioGRID:106825	BioGRID:109338	HIF1A	BioGRID	PubMed	Reconstituted Complex
BioGRID:106825	BioGRID:109431	HNRNPK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:109432	HNRNPL	BioGRID	PubMed	Reconstituted Complex
BioGRID:106825	BioGRID:116281	HNRNPUL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:109469	HOXC13	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:110054	KRT8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:110147	LGALS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:106825	BioGRID:110681	MUTYH	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106825	BioGRID:114402	NAE1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:110929	NPM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:116336	NUDT3	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:117939	PABPC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:114521	PAPSS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:111142	PCNA	BioGRID	PubMed	Reconstituted Complex
BioGRID:106825	BioGRID:107129	POLR3D	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:114956	PRDX6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:118151	PRPF19	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106825	BioGRID:114179	PSMG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:121946	RIC8A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:111974	RNF4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:110115	RPSA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:112316	SET	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:112319	SFPQ	BioGRID	PubMed	Co-fractionation
BioGRID:106825	BioGRID:112516	SNRPD1	BioGRID	PubMed	Co-fractionation
BioGRID:106825	BioGRID:112651	STAT3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:112783	TCEB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:112803	TCF21	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:112810	TCP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:112872	TERF1	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:112873	TERF2	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:119942	TERF2IP	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:112881	TFAP4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106825	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Co-purification
BioGRID:106825	BioGRID:113038	TRAF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:116472	TWF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:113146	TXN	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:113147	TXNRD1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106825	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106825	BioGRID:113177	UBE2I	BioGRID	PubMed	Two-hybrid
BioGRID:106825	BioGRID:122532	WDR77	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106825	BioGRID:116420	XPOT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106825	BioGRID:113349	XRCC1	BioGRID	PubMed	Far Western; Two-hybrid
BioGRID:106825	BioGRID:113353	XRCC5	BioGRID	PubMed	Reconstituted Complex
BioGRID:106825	BioGRID:110959	YBX1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106825	BioGRID:1205542	rev	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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BER complex, organism-specific biosystem (from KEGG)
BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
BER complex, conserved biosystem (from KEGG)
BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
Base Excision Repair, organism-specific biosystem (from REACTOME)
Base Excision Repair, organism-specific biosystemOf the three major pathways involved in the repair of nucleotide damage in DNA, base excision repair (BER) involves the greatest number of individual enzymatic activities. This is the consequence of...
Base excision repair, organism-specific biosystem (from KEGG)
Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Base excision repair, conserved biosystem (from KEGG)
Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem (from REACTOME)
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystemBase-free sugar-phosphate removal via the single-nucleotide replacement pathway requires displacement of DNA glycosylase by APE1, APE1 mediated endonucleolytic cleavage at the 5' side of the base-fre...
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
Displacement of DNA glycosylase by APE1, organism-specific biosystem (from REACTOME)
Displacement of DNA glycosylase by APE1, organism-specific biosystemFollowing cleavage of the damaged base, DNA glycosylase is displaced by APE1.
HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
HIF-2-alpha transcription factor network, organism-specific biosystem
HIF-2-alpha transcription factor network
Removal of DNA patch containing abasic residue, organism-specific biosystem (from REACTOME)
Removal of DNA patch containing abasic residue, organism-specific biosystemDuring removal of DNA patch containing abasic residue, DNA glycosylase is displaced by APE1 which endonucleolytically cleaves the 5' side of the base-free deoxyribose residue. POL Beta is recruite...
Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystem (from REACTOME)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystemWhile the single-nucleotide replacement pathway appears to facilitate the repair of most damaged bases, an alternative BER pathway is evoked when the structure of the terminal sugar phosphate is such...
Resolution of AP sites via the single-nucleotide replacement pathway, organism-specific biosystem (from REACTOME)
Resolution of AP sites via the single-nucleotide replacement pathway, organism-specific biosystemThe single-nucleotide replacement pathway of base excision repair appears to facilitate the repair of most damaged bases. Following DNA glycosylase mediated cleavage of the damaged base, the endonucl...
Resolution of Abasic Sites (AP sites), organism-specific biosystem (from REACTOME)
Resolution of Abasic Sites (AP sites), organism-specific biosystemResolution of AP sites can occur through the single-nucleotide replacement pathway or through the multiple-nucleotide patch replacement pathway.
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
TSH signaling pathway, organism-specific biosystem (from WikiPathways)
TSH signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland (1). TSH plays an important physiological role in the regulation of the hypothalamic-pit...

General gene information

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Markers

D2S2636 (e-PCR)
- UniSTS:70413

WI-18729 (e-PCR)
- UniSTS:63042

SHGC-36712 (e-PCR)
- UniSTS:60513

APEX1_1488.2 (e-PCR)
- UniSTS:280445

GDB:451907 (e-PCR)
- UniSTS:157388

APEX (e-PCR)
- UniSTS:479967

Genotypes

See APEX1 SNP Geneview Report
See APEX1 SNP Genotype Report
See APEX1 SNP Variation Viewer Report

Homology

Homologs of the APEX1 gene: The APEX1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
3'-5' exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
3'-5' exonuclease activity	TAS Traceable Author Statement more info	PubMed
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA-(apurinic or apyrimidinic site) lyase activity	IDA Inferred from Direct Assay more info	PubMed
DNA-(apurinic or apyrimidinic site) lyase activity	TAS Traceable Author Statement more info	PubMed
NF-kappaB binding	IEA Inferred from Electronic Annotation more info
RNA binding	IEA Inferred from Electronic Annotation more info
chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
endodeoxyribonuclease activity	TAS Traceable Author Statement more info	PubMed
endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IDA Inferred from Direct Assay more info	PubMed
oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
phosphodiesterase I activity	TAS Traceable Author Statement more info	PubMed
phosphoric diester hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	IEA Inferred from Electronic Annotation more info
ribonuclease H activity	TAS Traceable Author Statement more info	PubMed
site-specific endodeoxyribonuclease activity, specific for altered base	IDA Inferred from Direct Assay more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
transcription corepressor activity	TAS Traceable Author Statement more info	PubMed
uracil DNA N-glycosylase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
DNA demethylation	IDA Inferred from Direct Assay more info
DNA recombination	IEA Inferred from Electronic Annotation more info
DNA repair	IDA Inferred from Direct Assay more info	PubMed
DNA repair	TAS Traceable Author Statement more info
aging	IEA Inferred from Electronic Annotation more info
base-excision repair	TAS Traceable Author Statement more info
cell redox homeostasis	IEA Inferred from Electronic Annotation more info
cellular response to cAMP	IEA Inferred from Electronic Annotation more info
cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
cellular response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
oxidation-reduction process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
mitochondrion	IDA Inferred from Direct Assay more info
nuclear speck	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
ribosome	TAS Traceable Author Statement more info	PubMed
transcription factor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-(apurinic or apyrimidinic site) lyase

Names: DNA-(apurinic or apyrimidinic site) lyase; AP lyase; protein REF-1; redox factor-1; AP endonuclease class I; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic (abasic) endonuclease; deoxyribonuclease (apurinic or apyrimidinic)

NP_001231178.1

EC 4.2.99.18

NP_001632.2

EC 4.2.99.18

NP_542379.1

EC 4.2.99.18

NP_542380.1

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008718.1 RefSeqGene

Range

5001..7642

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001244249.1 → NP_001231178.1 DNA-(apurinic or apyrimidinic site) lyase

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses a donor splice site for exon 1 downstream of that used by variant 3.

Source sequence(s)

AI554786, AK291100, AL355075, CB139337

Consensus CDS

CCDS9550.1

UniProtKB/Swiss-Prot

P27695

UniProtKB/TrEMBL

Q5TZP7

Conserved Domains (1) summary

cd09087
Location:62 – 316
Blast Score: 1163

Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
NM_001641.3 → NP_001632.2 DNA-(apurinic or apyrimidinic site) lyase

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains the full-length first exon and is the longest transcript.

Source sequence(s)

AI554786, AK291100, AL355075

Consensus CDS

CCDS9550.1

UniProtKB/Swiss-Prot

P27695

UniProtKB/TrEMBL

Q5TZP7

Related

ENSP00000216714, OTTHUMP00000163989, ENST00000216714, OTTHUMT00000073641

Conserved Domains (1) summary

cd09087
Location:62 – 316
Blast Score: 1163

Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
NM_080648.2 → NP_542379.1 DNA-(apurinic or apyrimidinic site) lyase

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different donor splice site for exon 1 when compared to variant 1.

Source sequence(s)

AI554786, AL355075, BC004979

Consensus CDS

CCDS9550.1

UniProtKB/Swiss-Prot

P27695

UniProtKB/TrEMBL

Q5TZP7

Related

ENSP00000381111, OTTHUMP00000244793, ENST00000398030, OTTHUMT00000411060

Conserved Domains (1) summary

cd09087
Location:62 – 316
Blast Score: 1163

Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
NM_080649.2 → NP_542380.1 DNA-(apurinic or apyrimidinic site) lyase

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses a donor splice site for exon 1 downstream of that used by variant 2.

Source sequence(s)

AI554786, AL355075, BC095428

Consensus CDS

CCDS9550.1

UniProtKB/Swiss-Prot

P27695

UniProtKB/TrEMBL

Q5TZP7

Related

ENSP00000451979, OTTHUMP00000163988, ENST00000555414, OTTHUMT00000073640

Conserved Domains (1) summary

cd09087
Location:62 – 316
Blast Score: 1163

Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p10 Primary Assembly

Range

20923290..20925931

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

1044909..1047550

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018925.1 Alternate CHM1_1.0

Range

1922395..1925036

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01061230.1 (1550..4191)	None
genomic	AF488551.1	AAL86909.1
genomic	AL355075.6 (62198..64834)	None
genomic	AMYH01005588.1 (34257..36898)	None
genomic	CH471078.2	EAW66463.1
		EAW66464.1
		EAW66465.1
		EAW66466.1
		EAW66467.1
		EAW66468.1
genomic	D13370.1	BAA02633.1
genomic	M92444.1	AAA58629.1
genomic	M99703.1	AAA58373.1
genomic	X66133.1	CAA46925.1
mRNA	AI554786.1	None
mRNA	AK098588.1	None
mRNA	AK291100.1	BAF83789.1
mRNA	BC002338.2	AAH02338.1
mRNA	BC004979.1	AAH04979.1
mRNA	BC008145.1	AAH08145.1
mRNA	BC019291.1	AAH19291.1
mRNA	BC095428.1	AAH95428.1
mRNA	BT007236.1	AAP35900.1
mRNA	BT020133.1	AAV38935.1
mRNA	BX161454.1	CAD61917.1
mRNA	CB139337.1	None
mRNA	D90373.1	BAA14381.1
mRNA	M80261.1	AAA58371.1
mRNA	M81955.1	AAA58372.1
mRNA	S43127.1	AAB22977.1
mRNA	U79268.1	AAB50212.1
mRNA	X59764.1	CAA42437.1
other-genetic	DQ891814.2	ABM82740.1
other-genetic	DQ894998.2	ABM85924.1