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    Frq2 Frequenin 2 [ Drosophila melanogaster ]

    Gene ID: 32799, updated on 10-May-2012
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    Summary

    Official Symbol
    Frq2provided by Flybase
    Official Full Name
    Frequenin 2provided by Flybase
    Primary source
    FLYBASE:FBgn0083228
    Locus tag
    Dmel_CG5907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5907; Dmel\CG5907; frq; Frq; frq2
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    Genomic context

    Location :
    17A1-17A2
    Sequence :
    Chromosome: X; NC_004354.3 (18080190..18096871)
    See Frq2 in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene Frequenin 1 Neighboring gene CG12611 gene product from transcript CG12611-RA Neighboring gene HES-related Neighboring gene Holes in muscle

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Tessier CR, et al. Neurobiol Dis, 2011 Jan. PMID 20843478.
    2. Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication. Sánchez-Gracia A, et al. BMC Evol Biol, 2010 Feb 19. PMID 20170488.
    3. Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. Polevoy G, et al. J Cell Biol, 2009 Dec 14. PMID 19995935.
    4. Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth. Dason JS, et al. J Cell Sci, 2009 Nov 15. PMID 19861494.
    5. Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology. Romero-Pozuelo J, et al. Eur J Neurosci, 2007 Nov. PMID 17970740.

    See all (23) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Frq modulates Ca(2+) entry through a functional interaction with the alpha(1) voltage-gated Ca(2+)-channel subunit; this interaction regulates neurotransmission and nerve-terminal growth.
      Title: Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth.
    2. Synonymous substitutions have been prevalent in the evolution of the coding region of frq1 and frq2, indicating the presence of strong functional constraints following gene duplication.
      Title: Two frequenins in Drosophila: unveiling the evolutionary history of an unusual neuronal calcium sensor (NCS) duplication.
    3. We conclude that Frqs have two distinct functions: one in neurotransmission, regulating the probability of release per synapse, and another in axonal growth and bouton formation.
      Title: Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:59119 BioGRID:59058 CG12432    BioGRID  PubMed Two-hybrid 
    BioGRID:59119 BioGRID:59200 CG14191    BioGRID  PubMed Two-hybrid 
    BioGRID:59119 BioGRID:625088 CG17162    BioGRID  PubMed Two-hybrid 
    BioGRID:59119 BioGRID:57914 HLH4C    BioGRID  PubMed Two-hybrid 
    BioGRID:59119 BioGRID:60207 LanB1    BioGRID  PubMed Two-hybrid 
    BioGRID:59119 BioGRID:61486 SdhB    BioGRID  PubMed Two-hybrid 
    BioGRID:59119 BioGRID:73022 blos1    BioGRID  PubMed Two-hybrid 
    BioGRID:59119 BioGRID:62328 opa1-like    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG5907 gene product from transcript CG5907-RC
    Names
    CG5907-PA
    CG5907-PB
    CG5907-PC
    Frq2-PA
    Frq2-PB
    Frq2-PC
    frequenin
    frequenin 2
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      18080190..18096871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206778.2 → NP_996501.1  frequenin 2, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWX8
      Related
      FBpp0089318, FBtr0301628
      Conserved Domains (2) summary
      cd00051
      Location:68 – 125
      Blast Score: 129
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      COG5126
      Location:9 – 178
      Blast Score: 263
      FRQ1; Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]

    2. NM_080354.3 → NP_525093.1  frequenin 2, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWX8
      Related
      FBpp0074320, FBtr0074546
      Conserved Domains (2) summary
      cd00051
      Location:68 – 125
      Blast Score: 129
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      COG5126
      Location:9 – 178
      Blast Score: 263
      FRQ1; Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]

    3. NM_206779.2 → NP_996502.1  frequenin 2, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWX8
      Related
      FBpp0089317, FBtr0301627
      Conserved Domains (2) summary
      cd00051
      Location:68 – 125
      Blast Score: 129
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      COG5126
      Location:9 – 178
      Blast Score: 263
      FRQ1; Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT133347.1 AFF57512.1
    genomic AE014298.4 AAS65400.1
    genomic AE014298.4 AAF48809.1
    genomic AE014298.4 AAS65399.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWX8.1 GenPept
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    Additional Links

    Gene LinkOut

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