Frs2 fibroblast growth factor receptor substrate 2 [Mus musculus] - Gene

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Summary

Official Symbol: Frs2provided by MGI
Official Full Name: fibroblast growth factor receptor substrate 2provided by MGI
Primary source: MGI:1100860
See related: Ensembl:ENSMUSG00000020170
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SNT1; Frs2alpha; 4732458E18; C330018A15Rik

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Genomic context

Location :: 10 D2; 10

Sequence :: Chromosome: 10; NC_000076.6 (117070127..117148474, complement)

See Frs2 in Epigenomics, MapViewer

Chromosome 10 - NC_000076.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a novel signaling network containing FRS2, CAP and flotillin-1
Title: Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2.
FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
Title: FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
The FGF signaling axis activates mTOR via the FGF receptor substrate 2alpha (FRS2alpha)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs.
Title: FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts.
although Fgfr2 and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively.
Title: Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium.
Msx2 and Runx2 likely function together to induce PC-1 gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK signaling pathway
Title: FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling.
FRS2alpha fine-tunes the FGF2-signaling to control self-renewal and proliferation of neural stem cells through Hes1.
Title: FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.
Data show that PEA-15 prevents ERK1/2 localization to the plasma membrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activation of the ERK1/2 MAP kinase pathway.
Title: Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.
Trophoblast stem cell FRS2alpha mediates activation of the ERK pathway to enhance Cdx2 expression in response to FGF4. Cdx2 in turn binds to an FGF4-responsive enhancer element of the promoter region of Bmp4, leading to production and secretion of Bmp4.
Title: An FGF4-FRS2alpha-Cdx2 axis in trophoblast stem cells induces Bmp4 to regulate proper growth of early mouse embryos.
the renal hypoplasia observed in Frs2alpha(UB-/-) mice is likely secondary to decreased Ret and Wnt11 expression
Title: Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.
role in development and growth of neural progenitor cells
Title: Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells.

Submit: New GeneRIF Correction See all (26)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation
Targeted (knock-in) (2) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_808466.1	NP_034336.1	Fgfr1	BIND	PubMed	FGFR1 interacts with FRS2-alpha.
NP_808466.1	NP_034336.1	Fgfr1	BIND	PubMed	Fgfr1 interacts with FRS2. This interaction was modelled on a demonstrated interaction between mouse Fgfr1 and rat FRS2.
NP_808466.1	NP_032883.1	Prkci	BIND	PubMed	FRS2 interacts with PKC-lambda
BioGRID:236497	BioGRID:207564	Cks1b	BioGRID	PubMed	Reconstituted Complex
BioGRID:236497	BioGRID:199656	Fgfr1	BioGRID	PubMed	Biochemical Activity
BioGRID:236497	BioGRID:111570	PRKCI	BioGRID	PubMed	Reconstituted Complex
BioGRID:236497	BioGRID:202200	Prkci	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
insulin receptor binding	IEA Inferred from Electronic Annotation more info
neurotrophin TRKA receptor binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transmembrane receptor protein tyrosine kinase adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
activation of MAPK activity	IMP Inferred from Mutant Phenotype more info	PubMed
anterior/posterior axis specification, embryo	IMP Inferred from Mutant Phenotype more info	PubMed
fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
optic placode formation involved in camera-type eye formation	IMP Inferred from Mutant Phenotype more info	PubMed
organ induction	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: fibroblast growth factor receptor substrate 2

Names: fibroblast growth factor receptor substrate 2; SNT-1; FRS2-alpha; FGFR substrate 2; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177798.3 → NP_808466.1 fibroblast growth factor receptor substrate 2

Status: PROVISIONAL

Source sequence(s)

BC043109

Consensus CDS

CCDS24190.1

UniProtKB/Swiss-Prot

Q8C180

Related

ENSMUSP00000020381, ENSMUST00000020381

Conserved Domains (1) summary

cd01202
Location:14 – 115
Blast Score: 486

FRS2; Fibroblast growth factor receptor substrate 2 (FRS2/SNT1) Phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000076.6 Reference GRCm38 C57BL/6J

Range

117070127..117148474, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000032.1 Alternate Mm_Celera

Range

119013278..119091626, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL589661.21 (25524..103871)	None
genomic	CH466539.1	EDL21826.1	mixed
		EDL21827.1	mixed
		EDL21828.1	mixed
mRNA	AK028813.1	BAC26132.1	C57BL/6J
mRNA	AK031984.1	None	C57BL/6J
mRNA	AK049265.1	None	C57BL/6J
mRNA	AK138144.1	BAE23560.1	C57BL/6J
mRNA	AK163442.1	None	C57BL/6J
mRNA	BC043109.1	AAH43109.1	C57BL/6
mRNA	BC055334.1	AAH55334.1	C57BL/6