My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CG8188 [ Drosophila melanogaster ]

    Gene ID: 32751, updated on 8-Jan-2012
    Help top of page

    Summary

    Official Symbol
    CG8188provided by Flybase
    Primary source
    FLYBASE:FBgn0030863
    Locus tag
    Dmel_CG8188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8188; Ubc
    Help top of page

    Genomic context

    Location :
    16C1-16C1
    Sequence :
    Chromosome: X; NC_004354.3 (17593805..17596994, complement)
    See CG8188 in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene beta Spectrin Neighboring gene CG12990 gene product from transcript CG12990-RA Neighboring gene CG32556 gene product from transcript CG32556-RB Neighboring gene CG5884 gene product from transcript CG5884-RA Neighboring gene CG8173 gene product from transcript CG8173-RA

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Ali YO, et al. Hum Mol Genet, 2012 Jan 15. PMID 21965302.
    2. Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases. Galletti M, et al. Mol Cell Biol, 2009 Jun. PMID 19364825.
    3. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926.
    4. Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein. Kaplow ME, et al. Genetics, 2008 Apr. PMID 18430931.
    5. Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. Roukens MG, et al. Mol Cell Biol, 2008 Jul. PMID 18426905.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:59074 BioGRID:68008 RASSF8    BioGRID  PubMed Two-hybrid 
    BioGRID:59074 BioGRID:58214 Traf6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:59074 BioGRID:59621 aop    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:59074 BioGRID:57835 dm    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:59074 BioGRID:67624 loco    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:59074 BioGRID:58237 org-1    BioGRID  PubMed Two-hybrid 
    BioGRID:59074 BioGRID:77370 tau    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:59074 BioGRID:59781 tim    BioGRID  PubMed Affinity Capture-Western 
    Help top of page

    General gene information

    Homology

    • Homologs of the CG8188 gene: The CG8188 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, A.thaliana, and rice.

    Pathways from BioSystems

    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ubiquitin-protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    CG8188 gene product from transcript CG8188-RB
    Names
    CG8188
    CG8188-PA
    CG8188-PB
    NP_001033852.1
    NP_573237.2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      17593805..17596994, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038763.1 → NP_001033852.1  CG8188, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX25
      Related
      FBpp0099891, FBtr0100463
      Conserved Domains (1) summary
      cd00195
      Location:16 – 155
      Blast Score: 369
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_133009.2 → NP_573237.2  CG8188, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX25
      Related
      FBpp0074250, FBtr0074476
      Conserved Domains (1) summary
      cd00195
      Location:16 – 155
      Blast Score: 369
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT031269.1 ABY20510.1
    mRNA DQ151897.1 AAZ57342.1
    mRNA DQ151896.1 AAZ57341.1
    genomic AE014298.4 ABC67190.1
    genomic AE014298.4 AAF48756.2
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q9VX25.2 GenPept
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content