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AGFG1 ArfGAP with FG repeats 1 [ Homo sapiens (human) ]

Gene ID: 3267, updated on 8-May-2016
Official Symbol
AGFG1provided by HGNC
Official Full Name
ArfGAP with FG repeats 1provided by HGNC
Primary source
HGNC:HGNC:5175
See related
Ensembl:ENSG00000173744 HPRD:02918; MIM:600862; Vega:OTTHUMG00000133186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRB; RAB; RIP
Summary
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Orthologs
Location:
2q36.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (227472172..227561222)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (228336853..228425938)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene stress induced phosphoprotein 1 pseudogene 2 Neighboring gene mitochondrial fission factor Neighboring gene transmembrane 4 L six family member 20 Neighboring gene microRNA 5703 Neighboring gene spore coat protein SP96 Neighboring gene chromosome 2 open reading frame 83 Neighboring gene solute carrier family 19 member 3 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
ITGB5 and AGFG1 variants are associated with severity of airway responsiveness.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Rev rev Depletion of endogenous HIV-1 Rev binding protein (hRIP) by RNA interference results in the loss of viral replication in human cell lines and primary macrophages; virus production is restored to wild-type levels after reintroduction of hRIP protein PubMed
rev hRIP/Rab is known to interact with CRM1 (exportin 1) as part of its cofactor involvement with Rev-mediated nuclear export of HIV-1 mRNA PubMed
rev hRIP/Rab is a nucleoporin like protein that binds to the activation domain of HIV-1 Rev (amino acids 75-83) and acts as a cofactor for Rev-mediated nuclear export of HIV-1 mRNA PubMed
rev hRIP is an essential cellular HIV-1 Rev cofactor; abolishing hRIP activity with a dominant-negative mutant or RNA interference causes Rev-directed mRNAs to mislocalize and aberrantly accumulate at the nuclear periphery PubMed

Go to the HIV-1, Human Interaction Database

  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC116938, MGC116940, DKFZp686I15205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
intermediate filament organization IEA
Inferred from Electronic Annotation
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
spermatid nucleus differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic, membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear pore TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
arf-GAP domain and FG repeat-containing protein 1
Names
HIV-1 Rev binding protein
HIV-1 Rev-binding protein
Rab, Rev/Rex activation domain-binding protein
arf-GAP domain and FG repeats-containing protein 1
hRIP, Rev interacting protein
nucleoporin-like protein RIP
rev-interacting protein
rev/Rex activation domain-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135187.1NP_001128659.1  arf-GAP domain and FG repeat-containing protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC105286, AK097451, BQ016135, DB456989
    Consensus CDS
    CCDS46533.1
    UniProtKB/Swiss-Prot
    P52594
    Related
    ENSP00000387282, OTTHUMP00000204060, ENST00000409979, OTTHUMT00000331537
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8319
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  2. NM_001135188.1NP_001128660.1  arf-GAP domain and FG repeat-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001128660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC105286, BC096272, BQ016135, DB456989
    Consensus CDS
    CCDS46534.1
    UniProtKB/Swiss-Prot
    P52594
    Related
    ENSP00000387218, OTTHUMP00000204062, ENST00000409171, OTTHUMT00000331539
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8306
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  3. NM_001135189.1NP_001128661.1  arf-GAP domain and FG repeat-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001128661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC105286, BC096274, BQ016135, DB456989
    Consensus CDS
    CCDS46535.1
    UniProtKB/Swiss-Prot
    P52594
    Related
    ENSP00000362775, OTTHUMP00000204059, ENST00000373671, OTTHUMT00000331536
    Conserved Domains (1) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
  4. NM_004504.4NP_004495.2  arf-GAP domain and FG repeat-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_004495.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC105286, BC096273, BQ016135, DB456989
    Consensus CDS
    CCDS2467.1
    UniProtKB/Swiss-Prot
    P52594
    UniProtKB/TrEMBL
    A0A0S2Z444
    Related
    ENSP00000312059, OTTHUMP00000164242, ENST00000310078, OTTHUMT00000256895
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8306
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    227472172..227561222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712478.2XP_006712541.1  

    UniProtKB/TrEMBL
    A0A0S2Z462
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8319
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  2. XM_006712479.2XP_006712542.1  

    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8319
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  3. XM_005246516.2XP_005246573.1  

    UniProtKB/TrEMBL
    A0A0S2Z3Z1
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8319
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  4. XM_006712480.2XP_006712543.1  

    UniProtKB/TrEMBL
    A0A0S2Z3Y3
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8306
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  5. XM_011511072.1XP_011509374.1  

    Conserved Domains (1) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
  6. XM_011511071.1XP_011509373.1  

    Conserved Domains (1) summary
    cl02464
    Location:42120
    ArfGap; Putative GTPase activating protein for Arf
  7. XM_006712481.2XP_006712544.1  

    Conserved Domains (1) summary
    pfam03154
    Location:219373
    Atrophin-1; Atrophin-1 family

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    228342933..228431983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)