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slc14a2 solute carrier family 14 member 2 [ Danio rerio (zebrafish) ]

Gene ID: 326634, updated on 27-Mar-2024

Summary

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Official Symbol
slc14a2provided by ZNC
Official Full Name
solute carrier family 14 member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4833
See related
Ensembl:ENSDARG00000051914 AllianceGenome:ZFIN:ZDB-GENE-030131-4833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
UT; fe01a06; wu:fe01a06; zgc:136632
Summary
Predicted to enable serine-type endopeptidase activity and urea transmembrane transporter activity. Acts upstream of or within urea transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including EVL; digestive system; gill; muscle; and pronephros. Orthologous to several human genes including SLC14A1 (solute carrier family 14 member 1 (Kidd blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 5
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (52167740..52177824)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (51521469..51531231)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-198e13.3 Neighboring gene SET binding protein 1 Neighboring gene leucyl/cystinyl aminopeptidase Neighboring gene endoplasmic reticulum aminopeptidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The responses of zebrafish (Danio rerio) to high external ammonia and urea transporter inhibition: nitrogen excretion and expression of rhesus glycoproteins and urea transporter proteins. Braun MH, et al. J Exp Biol, 2009 Dec. PMID 19915127
  2. Nitrogenous Waste Handling by Larval Zebrafish Danio rerio in Alkaline Water. Kumai Y, et al. Physiol Biochem Zool, 2015 Mar-Apr. PMID 25730269
  3. Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters. Braun MH, et al. Am J Physiol Renal Physiol, 2009 May. PMID 19279128
  4. The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Fu J, et al. Ecotoxicol Environ Saf, 2020 Feb. PMID 31830605
  5. Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. Zhao XX, et al. J Biol Chem, 2016 Jan 1. PMID 26487724, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of UT caused urea excretion to decrease by approximately 90%
    Title: Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables urea transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in urea transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within urea transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within urea transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
urea transporter 2; urea transporter 1
Names
solute carrier family 14 (urea transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020519.1 → NP_001018355.1  urea transporter 2

    See identical proteins and their annotated locations for NP_001018355.1

    Status: PROVISIONAL

    Source sequence(s)
    AY788989
    UniProtKB/TrEMBL
    A4FUM6, Q533H0
    Related
    ENSDARP00000135209.1, ENSDART00000162256.2
    Conserved Domains (1) summary
    pfam03253
    Location:98 → 392
    UT; Urea transporter

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    52167740..52177824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476011.1 → XP_021331686.1  urea transporter 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q878
    Conserved Domains (1) summary
    pfam03253
    Location:58 → 353
    UT; Urea transporter
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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