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    RAB37 RAB37, member RAS oncogene family [ Homo sapiens ]

    Gene ID: 326624, updated on 11-May-2012
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    Summary

    Official Symbol
    RAB37provided by HGNC
    Official Full Name
    RAB37, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:30268
    See related
    Ensembl:ENSG00000172794; HPRD:06702; MIM:609956; Vega:OTTHUMG00000134282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ30284; FLJ32507
    Summary
    Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]
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    Genomic context

    Location :
    17q25.1
    Sequence :
    Chromosome: 17; NC_000017.10 (72667256..72743474)
    See RAB37 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene CD300 molecule-like family member d Neighboring gene chromosome 17 open reading frame 77 Neighboring gene CD300e molecule Neighboring gene CD300 molecule-like family member f Neighboring gene solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 Neighboring gene microRNA 3615 Neighboring gene N-acetyltransferase 9 (GCN5-related, putative)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. Danik JS, et al. Circ Cardiovasc Genet, 2009 Apr. PMID 20031577.
    3. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. Dobashi S, et al. Oncol Rep, 2009 Feb. PMID 19148500.
    4. Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer. Wu CY, et al. Lung Cancer, 2009 Mar. PMID 18687502.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Promoter/exon1 methylation is the predominant mechanism in down-regulation of the hRAB37, and can serve as a potential prediction biomarker of NSCLC progression.
      Title: Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.
    2. the TMEM22/RAB37 complex is likely to play a crucial role in growth of renal cell carcinoma
      Title: Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96AX2 Q01844 EWSR1    HPRD  PubMed  
    Q96AX2 P20339 RAB5A    HPRD  PubMed  
    Q96AX2 Q86UR5 RIMS1    HPRD  PubMed  
    BioGRID:130604 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:130604 BioGRID:111806 RAB5A    BioGRID  PubMed Two-hybrid 
    BioGRID:130604 BioGRID:116646 RIMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:130604 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasmic membrane-bounded vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    ras-related protein Rab-37
    Names
    ras-related protein Rab-37
    RAB37, member of RAS oncogene family
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006638.2 → NP_001006639.1  ras-related protein Rab-37 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (2) has a distinct and longer N-terminus, compared to isoform 3.
      Source sequence(s)
      AC016888, AK098068, BC016615
      Consensus CDS
      CCDS32722.1
      UniProtKB/Swiss-Prot
      Q96AX2
      Related
      ENSP00000376389, OTTHUMP00000165790, ENST00000392613, OTTHUMT00000258872
      Conserved Domains (2) summary
      COG1100
      Location:25 – 221
      Blast Score: 314
      COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
      cd04112
      Location:31 – 220
      Blast Score: 963
      Rab26; Rab GTPase family 26 (Rab26)

    2. NM_001163989.1 → NP_001157461.1  ras-related protein Rab-37 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (4) has a distinct and longer N-terminus, compared to isoform 3.
      Source sequence(s)
      AC016888, AK303442, BC016615
      Consensus CDS
      CCDS54161.1
      UniProtKB/Swiss-Prot
      Q96AX2
      Related
      ENSP00000376390, OTTHUMP00000165796, ENST00000392614, OTTHUMT00000258878
      Conserved Domains (2) summary
      COG1100
      Location:36 – 226
      Blast Score: 311
      COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
      cd04112
      Location:36 – 225
      Blast Score: 960
      Rab26; Rab GTPase family 26 (Rab26)

    3. NM_001163990.1 → NP_001157462.1  ras-related protein Rab-37 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents use of an alternate promoter, 5' UTR and alternate start codon, compared to variant 3. The resulting isoform (5) has a distinct and shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AC016888, AK098068, AK296172, BC016615
      Consensus CDS
      CCDS54162.1
      UniProtKB/Swiss-Prot
      Q96AX2
      Related
      ENSP00000376388, OTTHUMP00000165795, ENST00000392612, OTTHUMT00000258877
      Conserved Domains (1) summary
      cd04112
      Location:30 – 183
      Blast Score: 793
      Rab26; Rab GTPase family 26 (Rab26)

    4. NM_175738.4 → NP_783865.1  ras-related protein Rab-37 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 3.
      Source sequence(s)
      AC016888, AK290202, BC016615, DA164538
      Consensus CDS
      CCDS11703.1
      UniProtKB/Swiss-Prot
      Q96AX2
      Related
      ENSP00000383934, ENST00000402449
      Conserved Domains (2) summary
      COG1100
      Location:24 – 214
      Blast Score: 307
      COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
      cd04112
      Location:23 – 213
      Blast Score: 966
      Rab26; Rab GTPase family 26 (Rab26)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      72667256..72743474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      68076158..68153847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001006637.1: Suppressed sequence

      Description
      NM_001006637.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016888.23 (48963..117883) None
    genomic AC064805.13 (80549..87832) None
    genomic CH471099.1 EAW89177.1
      EAW89178.1
      EAW89179.1
      EAW89180.1
      EAW89181.1
      EAW89182.1
    mRNA AK054846.1 BAG51433.1
    mRNA AK057069.1 BAG51857.1
    mRNA AK098068.1 BAC05227.1
    mRNA AK127073.1 BAG54434.1
    mRNA AK290202.1 BAF82891.1
    mRNA AK296062.1 BAH12246.1
    mRNA AK296172.1 BAH12272.1
    mRNA AK303442.1 BAH13962.1
    mRNA BC016615.1 AAH16615.1
    mRNA BC040547.1 AAH40547.1
    mRNA DA164538.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96AX2.3 GenPept UniProtKB/Swiss-Prot:Q96AX2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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