if inflated [Drosophila melanogaster] - Gene

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Summary

Official Symbol: ifprovided by Flybase
Official Full Name: inflatedprovided by Flybase
Primary source: FLYBASE:FBgn0001250
Locus tag: Dmel_CG9623
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha2Int; alphaPS2; alphaPS2C; alpha[[PS2(ms8)]]; alpha[[PS2]]; aPS2; CG9623; CT27194; Dmel\CG9623; If; in; inf; PS 2; PS2; PS2alpha; PSalpha2

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Genomic context

Location :: 15A5-15A7; 1-55 cM

Sequence :: Chromosome: X; NC_004354.3 (16646222..16677467, complement)

See if in Epigenomics, MapViewer

Chromosome X - NC_004354.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest a model in which ERK phosphorylation must be spatially coupled to integrin-mediated DIM-7 activation to make a complex that can be imported efficiently.
Title: Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7.
Alternative splicing in integrin alpha subunit extracellular domains may affect ligand affinity via relatively subtle alterations in integrin conformation.
Title: Modulation of ligand binding by alternative splicing of the alphaPS2 integrin subunit.
Three mutations that alter different parts of the alphaPS2 beta-propeller, plus a fourth that eliminated a late phase of alphaPS2 expression, all led to a strong decrease in alphaPS2betaPS at muscle ends, but normal levels of talin were recruited.
Title: Mutations in the Drosophila alphaPS2 integrin subunit uncover new features of adhesion site assembly.
analysis of binding by Drosophila alphaPS2betaPS integrin to ligands
Title: Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity.
interaction with gene encoding moleskin
Title: Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7.
We also demonstrate a role for integrin function in salivary gland migration.
Title: Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:58994	BioGRID:58322	Dsor1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58994	BioGRID:61444	EcR	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58994	BioGRID:63563	RpL19	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58994	BioGRID:63464	bs	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58994	BioGRID:60645	crol	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58994	BioGRID:69557	csw	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58994	BioGRID:67557	how	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:58994	BioGRID:58660	mew	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:58994	BioGRID:69244	msk	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58994	BioGRID:69357	mys	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:58994	BioGRID:77545	p53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:58994	BioGRID:57758	phl	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58994	BioGRID:63189	px	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58994	BioGRID:62473	sli	BioGRID	PubMed	Phenotypic Suppression
BioGRID:58994	BioGRID:57797	ttm50	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the if gene: The if gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

Pathways from BioSystems

Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
Integrin alphaIIb beta3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
Platelet Aggregation (Plug Formation), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p130Cas linkage to MAPK signaling for integrins, organism-specific biosystem (from REACTOME)
p130Cas linkage to MAPK signaling for integrins, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
receptor activity	IDA Inferred from Direct Assay more info	PubMed
receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
apposition of dorsal and ventral imaginal disc-derived wing surfaces	NAS Non-traceable Author Statement more info	PubMed
axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
axonal defasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
cell adhesion	IDA Inferred from Direct Assay more info	PubMed
cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration	TAS Traceable Author Statement more info	PubMed
cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
epithelial cell migration, open tracheal system	TAS Traceable Author Statement more info	PubMed
heterophilic cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
imaginal disc-derived wing morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived wing morphogenesis	TAS Traceable Author Statement more info	PubMed
maintenance of epithelial integrity, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed
midgut development	TAS Traceable Author Statement more info	PubMed
muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
salivary gland development	TAS Traceable Author Statement more info	PubMed
salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
sensory perception of smell	IGI Inferred from Genetic Interaction more info	PubMed
tracheal outgrowth, open tracheal system	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
contractile fiber	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integrin complex	IEA Inferred from Electronic Annotation more info
integrin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
integrin complex	NAS Non-traceable Author Statement more info
integrin complex	TAS Traceable Author Statement more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG9623 gene product from transcript CG9623-RC

Names: CG9623-PB; CG9623-PC; CG9623-PD; CG9623-PF; alpha integrin; alpha-PS2-integrin; alpha2 integrin; alphaPS2 integrin; alphaPS2-integrin; alpha[[PS2]] integrin; if-PB; if-PC; if-PD; if-PF; inflated; position-specific antigen 2

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.3

Range

16646222..16677467, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167544.2 → NP_728021.2 inflated, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q8IR07

Related

FBpp0290566, FBtr0301352

Conserved Domains (2) summary

pfam08441
Location:474 – 878
Blast Score: 940

Integrin_alpha2; Integrin alpha

cl15299
Location:373 – 426
Blast Score: 154

FG-GAP; FG-GAP repeat
NM_078654.2 → NP_523378.2 inflated, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJN2

UniProtKB/Swiss-Prot

P12080

Related

FBpp0074131, FBtr0074357

Conserved Domains (2) summary

pfam08441
Location:499 – 903
Blast Score: 941

Integrin_alpha2; Integrin alpha

cl15299
Location:398 – 451
Blast Score: 154

FG-GAP; FG-GAP repeat
NM_001169306.1 → NP_001162777.1 inflated, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJN2

UniProtKB/Swiss-Prot

P12080

Related

FBpp0290567, FBtr0301353

Conserved Domains (2) summary

pfam08441
Location:499 – 903
Blast Score: 941

Integrin_alpha2; Integrin alpha

cl15299
Location:398 – 451
Blast Score: 154

FG-GAP; FG-GAP repeat
NM_001169307.1 → NP_001162778.1 inflated, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJN2

UniProtKB/Swiss-Prot

P12080

Related

FBpp0290568, FBtr0301354

Conserved Domains (2) summary

pfam08441
Location:499 – 903
Blast Score: 941

Integrin_alpha2; Integrin alpha

cl15299
Location:398 – 451
Blast Score: 154

FG-GAP; FG-GAP repeat