ERAS ES cell expressed Ras [Homo sapiens] - Gene

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Summary

Official Symbol: ERASprovided by HGNC
Official Full Name: ES cell expressed Rasprovided by HGNC
Primary source: HGNC:5174
See related: Ensembl:ENSG00000187682; HPRD:02339; MIM:300437; Vega:OTTHUMG00000059533
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HRAS2; HRASP; MGC126691; MGC126693

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Genomic context

Location :: Xp11.23

Sequence :: Chromosome: X; NC_000023.10 (48687283..48688548)

See ERAS in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ERas may be a potential biomarker for gastric cancer, but advanced studies are wanted.
Title: Detection of β-catenin, gastrokine-2 and embryonic stem cell expressed ras in gastric cancers.
These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin.
Title: Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer.
ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma.
Title: Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells.
Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer.
Title: Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells.
High ERas is associated with the tumorigenic process of gastric carcinomas.
Title: Expression of ERas oncogene in gastric carcinoma.
rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms
Title: A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
Studies on ERas gene expression.
Title: Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript.
transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells
Title: Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells	PubMed
	env	HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation	PubMed
Tat	tat	HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells	PubMed
	tat	HIV-1 Tat induces ERK phosphorylation by the activation of the small GTPase Ras, but not the small GTPase Rac, in human endothelial cells	PubMed
	tat	HIV-1 Tat activates the small GTPases Ras and Rac and the mitogen-activated protein kinase ERK when expressed in human endothelial cells; this effect is mediated through the arginine-glycine-aspartic (RGD) region of Tat	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Q7Z444	O00329	PIK3CD	HPRD	PubMed
Q7Z444	P27986	PIK3R1	HPRD	PubMed
BioGRID:109502	BioGRID:111312	PIK3CG	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109502	BioGRID:111831	RAF1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: GTPase ERas

Names: GTPase ERas; E-Ras; small GTPase protein E-Ras; embryonic stem cell-expressed Ras; v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2; v-Ha-ras Harvey rat sarcoma viral oncogene homolog pseudogene

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181532.2 → NP_853510.1 GTPase ERas precursor

Status: PROVISIONAL

Source sequence(s)

AB093575

Consensus CDS

CCDS35246.1

UniProtKB/Swiss-Prot

Q7Z444

Related

ENSP00000339136, OTTHUMP00000065857, ENST00000338270, OTTHUMT00000132402

Conserved Domains (1) summary

cd04139
Location:57 – 201
Blast Score: 540

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

48687283..48688548

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

46346998..46348263

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF196971.2 (48396..49661)	None
genomic	CH471224.1	EAW50743.1
genomic	X00419.1 (364..1171)	None
mRNA	AB093575.1	BAC76997.1
mRNA	BC101642.1	AAI01643.1
mRNA	BC101644.1	AAI01645.1