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r rudimentary [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32640, updated on 4-Apr-2024

Summary

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Official Symbol
rprovided by FlyBase
Official Full Name
rudimentaryprovided by FlyBase
Primary source
FLYBASE:FBgn0003189
Locus tag
Dmel_CG18572
See related
AllianceGenome:FB:FBgn0003189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACT; CAD; CG18572; CG4601; CPS; csp2; DHO; Dmel\CG18572; DRORUD; fs(1)829; fs(1)M34; GAT; l(1)Ab; PYR1; R; Su(b)
Summary
Enables aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process and glutamine metabolic process. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
14F5-15A1; 1-54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16655359..16668712)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16549392..16562745)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene methuselah-like 1 Neighboring gene long non-coding RNA:CR46147 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nuclear envelope integral membrane protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes. Terakawa A, et al. iScience, 2022 May 20. PMID 35494245, Free PMC Article
  2. Organization of the Rudimentary Wing Locus in DROSOPHILA MELANOGASTER. I. the Isolation and Partial Characterization of Mutants Induced with Ethyl Methanesulfonate, Icr-170 and X Rays. Rawls JM, et al. Genetics, 1979 Sep. PMID 17248960, Free PMC Article
  3. Studies on female-sterility genes in Drosophila melanogaster. III. The effects of the gene rudimentary on embryonic development. COUNCE SJ. Z Indukt Abstamm Vererbungsl, 1956. PMID 13338459
  4. Evolutionary relationships of the carbamoylphosphate synthetase genes. van den Hoff MJ, et al. J Mol Evol, 1995 Dec. PMID 8587126
  5. Sequence of the novel joints present in the amplified DNA of N-phosphonacetyl-L-aspartate resistant Drosophila cells: implication on the mechanisms of amplification in these cells. Azou Y, et al. Biol Cell, 1993. PMID 8364394

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IC
Inferred by Curator
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
  
enables aspartate carbamoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate carbamoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartate carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartate carbamoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carboxyl- or carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutamine binding IC
Inferred by Curator
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in citrulline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine metabolic process IC
Inferred by Curator
more info
  
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rudimentary
Names
CG18572-PA
CG18572-PD
CG18572-PE
Suppressor-of-black
carbamoylphosphate synthetase
r-PA
r-PD
r-PE
rudimentary gene
suppressor of black
NP_001285343.1
NP_523377.1
NP_996488.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16655359..16668712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078653.2 → NP_523377.1  rudimentary, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523377.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5X540, O97163, P05990, Q26376, Q7KUX4, Q8SXM0, Q9VXD5
    UniProtKB/TrEMBL
    X2JFG0
    Related
    FBpp0088675
    Conserved Domains (13) summary
    cd01744
    Location:196 → 371
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    PLN02527
    Location:1918 → 2220
    PLN02527; aspartate carbamoyltransferase
    cd01316
    Location:1475 → 1821
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    cd01423
    Location:1327 → 1453
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01368
    Location:7 → 376
    CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
    TIGR01369
    Location:403 → 1455
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00185
    Location:2067 → 2216
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam00988
    Location:7 → 151
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02729
    Location:1919 → 2060
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
    pfam02786
    Location:524 → 726
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:815 → 935
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:1084 → 1265
    ATP-grasp_4; ATP-grasp domain
    cl21455
    Location:947 → 1149
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_206765.3 → NP_996488.2  rudimentary, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5X540, O97163, P05990, Q26376, Q7KUX4, Q8SXM0, Q9VXD5
    UniProtKB/TrEMBL
    X2JFG0
    Conserved Domains (13) summary
    cd01744
    Location:196 → 371
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    PLN02527
    Location:1918 → 2220
    PLN02527; aspartate carbamoyltransferase
    cd01316
    Location:1475 → 1821
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    cd01423
    Location:1327 → 1453
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01368
    Location:7 → 376
    CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
    TIGR01369
    Location:403 → 1455
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00185
    Location:2067 → 2216
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam00988
    Location:7 → 151
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02729
    Location:1919 → 2060
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
    pfam02786
    Location:524 → 726
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:815 → 935
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:1084 → 1265
    ATP-grasp_4; ATP-grasp domain
    cl21455
    Location:947 → 1149
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001298414.1 → NP_001285343.1  rudimentary, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285343.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5X540, O97163, P05990, Q26376, Q7KUX4, Q8SXM0, Q9VXD5
    UniProtKB/TrEMBL
    X2JFG0
    Conserved Domains (13) summary
    cd01744
    Location:196 → 371
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    PLN02527
    Location:1918 → 2220
    PLN02527; aspartate carbamoyltransferase
    cd01316
    Location:1475 → 1821
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    cd01423
    Location:1327 → 1453
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01368
    Location:7 → 376
    CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
    TIGR01369
    Location:403 → 1455
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00185
    Location:2067 → 2216
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam00988
    Location:7 → 151
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02729
    Location:1919 → 2060
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
    pfam02786
    Location:524 → 726
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:815 → 935
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:1084 → 1265
    ATP-grasp_4; ATP-grasp domain
    cl21455
    Location:947 → 1149
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05990.3 P05990
X2JFG0 X2JFG0

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