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    Pp2B-14D Protein phosphatase 2B at 14D [ Drosophila melanogaster ]

    Gene ID: 32624, updated on 19-May-2012
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    Summary

    Official Symbol
    Pp2B-14Dprovided by Flybase
    Official Full Name
    Protein phosphatase 2B at 14Dprovided by Flybase
    Primary source
    FLYBASE:FBgn0011826
    Locus tag
    Dmel_CG9842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    canA; CanA14D; CG9842; CnA; CnnA14D; D33; Dmel\CG9842; DmPp2B-14D; Pp12-14D; PP2B; PP2B 14D; PP2B-14D; Pp2B-14DF; PpD33
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    Genomic context

    Location :
    14E1-14E3
    Sequence :
    Chromosome: X; NC_004354.3 (16448844..16454056, complement)
    See Pp2B-14D in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene CG9902 gene product from transcript CG9902-RA Neighboring gene Actin-related protein 14D Neighboring gene Calcineurin A at 14F Neighboring gene CG13014 gene product from transcript CG13014-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. Takeo S, et al. Dev Biol, 2010 Aug 15. PMID 20561515.
    3. Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Ha EM, et al. Nat Immunol, 2009 Sep. PMID 19668222.
    4. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Wang B, et al. Cell Metab, 2008 May. PMID 18460334.
    5. Drosophila calcineurin promotes induction of innate immune responses. Dijkers PF, et al. Curr Biol, 2007 Dec 4. PMID 18060786.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:58962 BioGRID:62391 BEAF-32    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:65591 CG10508    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:61933 CG12934    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:57560 CG13373    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:72585 CG15126    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:57924 CG15472    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:58666 CG15745    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:625088 CG17162    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:60245 CG8455    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:68520 CanA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:58962 BioGRID:68974 CanB    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:58962 BioGRID:70250 CanB2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:58962 BioGRID:63083 Egfr    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:58962 BioGRID:71025 Eip63F-1    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:64545 Gap1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:58962 BioGRID:62791 GstE7    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:63549 NaCP60E    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:64484 Nf-YA    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:66301 Ras85D    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:58962 BioGRID:63351 Sesn    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:61901 Syb    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:66917 Tm2    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:68605 ci    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:67226 gl    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:58962 BioGRID:74715 hoe1    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:59324 l(1)G0004    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:64424 orb2    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:67700 pnt    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:58962 BioGRID:62080 skpB    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:58941 sl    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:58962 BioGRID:58433 sofe    BioGRID  PubMed Two-hybrid 
    BioGRID:58962 BioGRID:63919 sty    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:58962 BioGRID:62362 ttv    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Pp2B-14D gene: The Pp2B-14D gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.

    Pathways from BioSystems

    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    calcium-dependent protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    female meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    meiosis IGI
    Inferred from Genetic Interaction
    more info
    		  
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    sleep IDA
    Inferred from Direct Assay
    more info
    		  
    wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    calcineurin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    calcineurin complex NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG9842 gene product from transcript CG9842-RC
    Names
    CG9842-PA
    CG9842-PB
    CG9842-PC
    Pp2B-14D-PA
    Pp2B-14D-PB
    Pp2B-14D-PC
    calcineurin
    protein phosphatase 2B at 14D
    protein phosphatase D33
    protein phosphatase from PCR fragment D33
    NP_001245715.1
    NP_001245716.1
    NP_523373.2
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      16448844..16454056, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258786.1 → NP_001245715.1  protein phosphatase 2B at 14D, isoform C [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_001258787.1 → NP_001245716.1  protein phosphatase 2B at 14D, isoform B [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_078649.3 → NP_523373.2  protein phosphatase 2B at 14D, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27889
      Related
      FBpp0074069
      Conserved Domains (2) summary
      cd07416
      Location:107 – 411
      Blast Score: 1741
      MPP_PP2B; PP2B, metallophosphatase domain
      smart00156
      Location:127 – 395
      Blast Score: 989
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 AFH07428.1
    genomic AE014298.4 AFH07429.1
    genomic AE014298.4 AAF48622.1
    mRNA BT010083.1 AAQ22552.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27889.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content

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