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    APC adenomatous polyposis coli [ Homo sapiens ]

    Gene ID: 324, updated on 20-May-2012
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    Summary

    Official Symbol
    APCprovided by HGNC
    Official Full Name
    adenomatous polyposis coliprovided by HGNC
    Primary source
    HGNC:583
    See related
    Ensembl:ENSG00000134982; HPRD:01439; MIM:611731; Vega:OTTHUMG00000128806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
    Summary
    This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5q21-q22
    Sequence :
    Chromosome: 5; NC_000005.9 (112043202..112181936)
    See APC in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene uncharacterized FLJ11235 Neighboring gene transmembrane protein 183A pseudogene Neighboring gene chromobox homolog 3 pseudogene 3 Neighboring gene signal recognition particle 19kDa Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. In vitro stability of APC gene sequences and the influence of DNA repair status. Turnbull CL, et al. Mutagenesis, 2012 Mar. PMID 22294772.
    2. Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. Valvezan AJ, et al. J Biol Chem, 2012 Feb 3. PMID 22184111.
    3. The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP). Claes K, et al. Acta Gastroenterol Belg, 2011 Sep. PMID 22103048.
    4. Activation of beta-catenin is a late event in the pathogenesis of nephroblastomas and rarely correlated with genetic changes of the APC gene. Grill C, et al. Pathology, 2011 Dec. PMID 22081130.
    5. Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma. Jain S, et al. PLoS One, 2011. PMID 22073196.

    See all (552) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Mutations in APC is associated with stability of APC gene sequences and DNA repair and leads to colorectal carcinogenesis.
      Title: In vitro stability of APC gene sequences and the influence of DNA repair status.
    2. Among 21 brain metastases analyzed, 58.8% of samples showed loss of heterozygosity of the adenomatous polyposis coli gene.
      Title: Brain metastases exhibit gross deletions of the APC gene.
    3. In sporadic colorectal tumourspatients, the most frequently mutated gene was APC (68.9% of tumours), followed by KRAS (31.1%), TP53 (27.2%), BRAF (8.7%) and CTNNB1 (1.9%).
      Title: Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients.
    4. APC regulation of GSK-3 also provides a novel mechanism for Wnt regulation of multiple downstream effectors, including beta-catenin and mTOR.
      Title: Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.
    5. methylation of the sense strand of APC occurred in 40% of HCCs from patients with serum AFP levels less than 20 ng/mL, suggesting a potential role for APC as a biomarker to complement AFP in HCC screening
      Title: Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma.
    6. nuclear activation of beta-catenin is a late event in the tumorigenesis of nephroblastomas coinciding in some tumours with LOH of the APC gene.
      Title: Activation of beta-catenin is a late event in the pathogenesis of nephroblastomas and rarely correlated with genetic changes of the APC gene.
    7. novel mutations associated with familial adenomatous polyposis identified. mutations observed reinforce importance of a wide array of diagnostic techniques, including RNA-based testing, cDNA sequencing and multiplex ligation-dependent probe amplification.
      Title: A survey of APC mutations in Quebec.
    8. the tumor suppressor adenomatous polyposis coli controls microtubule targeting to the cell base to drive apical extrusion during cell death
      Title: The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium.
    9. Patients with colorectal cancer have a larger variance in germline levels of allele-specific expression in APC than controls; large distances from the mean ASE were associated with risk for common forms of CRC.
      Title: Increased variance in germline allele-specific expression of APC associates with colorectal cancer.
    10. Data indicate that APC is required for appropriate axon morphological development and that the N-terminus of APC is important for regulation of the neuronal cytoskeleton.
      Title: Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus.
    Submit: New GeneRIF Correction See all (352)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Adenoma, periampullary, somatic

    Brain tumor-polyposis syndrome 2

    Colorectal cancer, somatic

    Colorectal cancer, somatic, 114500 Gastric cancer, somatic

    Desmoid disease, hereditary

    Gastric cancer, somatic

    Hepatoblastoma, somatic

    Medulloblastoma

    Turcot syndrome

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000029.2 ARHGEF4    BIND  PubMed APC interacts with Asef. This interaction was modeled on a demonstrated interaction between human APC and Asef from an unspecified species. 
    NP_000029.2 NP_001319.1 CTBP1    BIND  PubMed CtBP interacts with APC. 
    NP_000029.2 NP_001895.1 CTNNB1    BIND  PubMed APC interacts with Beta-catenin. 
    NP_000029.2 NP_001895.1 CTNNB1    BIND  PubMed Beta-catenin interacts with APC. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse Apc. 
    NP_000029.2 NP_003861.1 IQGAP1    BIND  PubMed APC interacts with IQGAP1. 
    P25054 P25054 APC    HPRD  PubMed  
    P25054 Q9NR80 ARHGEF4    HPRD  PubMed  
    P25054 O15169 AXIN1    HPRD  PubMed  
    P25054 Q9Y2T1 AXIN2    HPRD  PubMed  
    P25054 O43683 BUB1    HPRD  PubMed  
    P25054 P49674 CSNK1E    HPRD  PubMed  
    P25054 Q13363 CTBP1    HPRD  PubMed  
    P25054 P35222 CTNNB1    HPRD  PubMed  
    P25054 O14490 DLGAP1    HPRD  PubMed  
    P25054 P49841 GSK3B    HPRD  PubMed  
    P25054 P46940 IQGAP1    HPRD  PubMed  
    P25054 P14923 JUP    HPRD  PubMed  
    P25054 Q92845 KIFAP3    HPRD  PubMed  
    P25054 Q15691 MAPRE1    HPRD  PubMed  
    P25054 P15941 MUC1    HPRD  PubMed  
    P25054 Protein phosphatase 2A, catalytic subunit, alpha isoform PPP2CA    HPRD  PubMed  
    P25054 Q15172 PPP2R5A    HPRD  PubMed  
    P25054 P17612 PRKACA    HPRD  PubMed  
    P25054 Q12923 PTPN13    HPRD  PubMed  
    P25054 P56715 RP1    HPRD  PubMed  
    P25054 Q8IUQ4 SIAH1    HPRD  PubMed  
    P25054 P05549 TFAP2A    HPRD  PubMed  
    P25054 P68366 TUBA4A    HPRD  PubMed  
    BioGRID:106821 BioGRID:106602 ACTN1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:109503 AGFG1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:117519 ANKRD17    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:106672 AP2B1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:106821 APC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106821 BioGRID:119114 ARHGEF4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106821 BioGRID:113909 AXIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106821 BioGRID:113910 AXIN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:249455 Axin1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106821 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106821 BioGRID:107164 BUB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106821 BioGRID:107166 BUB1B    BioGRID  PubMed Biochemical Activity 
    BioGRID:106821 BioGRID:114621 BUB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:107181 C4A    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:124384 CGNL1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:117365 COG4    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:115729 COG5    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:107777 CREBBP    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:107836 CSNK1A1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106821 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106821 BioGRID:107843 CSNK2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:107876 CTNNA1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106821 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex 
    BioGRID:106821 BioGRID:114687 CYTH2    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:217741 Ckap5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106821 BioGRID:108085 DLG3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106821 BioGRID:114660 DLGAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:107135 DST    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:108348 EPAS1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:120997 ERBB2IP    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116715 EXPH5    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:121108 FAM214A    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:123879 FBXO30    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:118877 FHOD1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:108605 FLNA    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:117520 GIGYF2    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:109063 GOLGA2    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:114593 HGS    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110751 HNRNPM    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:109541 HSPA5    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:124016 ING5    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:109931 JUP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106821 BioGRID:121595 KIAA1328    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110000 KIF5B    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116582 KIFAP3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106821 BioGRID:110058 KRT13    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110059 KRT14    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110064 KRT15    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110070 KRT17    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110078 KRT19    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:117467 KRT23    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110050 KRT5    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110103 LAMA3    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110104 LAMA4    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116528 LPHN1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:117048 MACF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110260 MAD2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:116581 MAPRE1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106821 BioGRID:116178 MAPRE2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106821 BioGRID:120892 MBD5    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:114406 MCM3AP    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110669 MUC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106821 BioGRID:110713 MYH10    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110714 MYH11    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110730 MYO6    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:124605 NAV1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:124606 NAV2    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:124604 NAV3    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:131288 NCKAP5    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:121726 NCKAP5L    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110634 ND4    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110783 NEB    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:125446 NOSTRIN    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:115297 NUP153    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:113717 NUP214    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:119759 NUP54    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:110982 NUP98    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:115157 NUPL1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116278 NUPL2    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:117448 PNISR    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:115214 POM121    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:755836 POM121C    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116948 PPP1R13B    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:111517 PPP2R5A    BioGRID  PubMed Co-localization 
    BioGRID:106821 BioGRID:111680 PSMD1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:111683 PSMD4    BioGRID  PubMed Biochemical Activity 
    BioGRID:106821 BioGRID:111839 RANBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:115359 RANBP9    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:123760 RBM4B    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:112146 RPS27    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116539 SEC31A    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106821 BioGRID:112372 SIAH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106821 BioGRID:114574 SMC3    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116661 SNRNP200    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116960 SPECC1L    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:112589 SPTBN1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:112590 SPTBN2    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:116928 SYNE1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:112735 TAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:112878 TFAP2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106821 BioGRID:113028 TPR    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:112615 TRIM21    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:113128 TUBA4A    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:106821 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106821 BioGRID:113348 XPO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106821 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106821 BioGRID:122154 ZFP106    BioGRID  PubMed Two-hybrid 
    BioGRID:106821 BioGRID:120139 ZRANB1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: SRP19

    Homology

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
      Beta-catenin phosphorylation cascade, organism-specific biosystemDegradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated p...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical Wnt signaling pathway, organism-specific biosystem
      Canonical Wnt signaling pathway
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Irinotecan Pathway, organism-specific biosystem (from WikiPathways)
      Irinotecan Pathway, organism-specific biosystemThis pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inactiv...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of CDC42 activity, organism-specific biosystem
      Regulation of CDC42 activity
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT cadherin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    axis specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    canonical Wnt receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    canonical Wnt receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokinesis after mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hair follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    muscle cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of canonical Wnt receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of epithelial cell proliferation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of odontogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of pseudopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proximal/distal pattern formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of attachment of spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of nitrogen compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		  
    skin development IEA
    Inferred from Electronic Annotation
    more info
    		  
    somatic stem cell maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    thymus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    tight junction assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    APC-Axin-1-beta-catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Axin-APC-beta-catenin-GSK3B complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    axonal growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule plus end IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    adenomatous polyposis coli protein
    Names
    adenomatous polyposis coli protein
    deleted in polyposis 2.5
    adenomatosis polyposis coli tumor suppressor
    protein phosphatase 1, regulatory subunit 46
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008481.4 RefSeqGene

      Range
      19985..158719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_130

    mRNA and Protein(s)

    1. NM_000038.5 → NP_000029.2  adenomatous polyposis coli protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663, M73548
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Related
      ENSP00000257430, OTTHUMP00000159019, ENST00000257430, OTTHUMT00000250738
      Conserved Domains (7) summary
      cd00020
      Location:611 – 731
      Blast Score: 203
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05937
      Location:2670 – 2843
      Blast Score: 630
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:1636 – 1661
      Blast Score: 105
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:1719 – 1738
      Blast Score: 89
      SAMP; SAMP Motif
      pfam05956
      Location:2223 – 2568
      Blast Score: 747
      APC_basic; APC basic domain
      pfam11414
      Location:157 – 208
      Blast Score: 186
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      cl02500
      Location:311 – 413
      Blast Score: 98
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    2. NM_001127510.2 → NP_001120982.1  adenomatous polyposis coli protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Related
      ENSP00000427089, OTTHUMP00000222841, ENST00000508376, OTTHUMT00000370794
      Conserved Domains (7) summary
      cd00020
      Location:611 – 731
      Blast Score: 203
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05937
      Location:2670 – 2843
      Blast Score: 630
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:1636 – 1661
      Blast Score: 105
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:1719 – 1738
      Blast Score: 89
      SAMP; SAMP Motif
      pfam05956
      Location:2223 – 2568
      Blast Score: 747
      APC_basic; APC basic domain
      pfam11414
      Location:157 – 208
      Blast Score: 186
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      cl02500
      Location:311 – 413
      Blast Score: 98
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    3. NM_001127511.2 → NP_001120983.2  adenomatous polyposis coli protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (a).
      Source sequence(s)
      AB210001, AK294544, BP230350, CA313732
      UniProtKB/TrEMBL
      B7Z2B6
      UniProtKB/TrEMBL
      Q4LE70
      Related
      ENSP00000423224, OTTHUMP00000222839, ENST00000507379, OTTHUMT00000370792
      Conserved Domains (7) summary
      cd00020
      Location:593 – 713
      Blast Score: 205
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05937
      Location:2652 – 2825
      Blast Score: 628
      EB1_binding; EB-1 Binding Domain
      pfam05923
      Location:1618 – 1643
      Blast Score: 105
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:1701 – 1720
      Blast Score: 90
      SAMP; SAMP Motif
      pfam05956
      Location:2205 – 2550
      Blast Score: 741
      APC_basic; APC basic domain
      pfam11414
      Location:167 – 218
      Blast Score: 188
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      cl02500
      Location:293 – 395
      Blast Score: 99
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      112043202..112181936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      107222330..107361030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008575.7 (78383..135617) None
    genomic AC136500.1 None
    genomic AY682982.1 AAT81590.1
    genomic AY900441.1 AAW82777.1
    genomic AY925197.1 AAX07544.1
    genomic S78214.1 AAB21145.2
    mRNA AB210001.1 BAE06083.1
    mRNA AF038181.1 None
    mRNA AI492038.1 None
    mRNA AK289567.1 BAF82256.1
    mRNA AK294544.1 BAH11802.1
    mRNA AK309033.1 None
    mRNA BC034955.1 None
    mRNA BC056268.1 AAH56268.1
    mRNA BE047584.1 None
    mRNA BF112110.1 None
    mRNA BG548363.1 None
    mRNA BM271918.1 None
    mRNA BM713901.1 None
    mRNA BM975470.1 None
    mRNA BP230350.1 None
    mRNA CA313732.1 None
    mRNA DA777787.1 None
    mRNA DA795663.1 None
    mRNA M73548.1 AAA60353.1
      AAA60354.1
    mRNA M74088.1 AAA03586.1
    mRNA S56365.1 AAD14918.1
    mRNA S67787.1 AAD13997.1
    mRNA S67788.1 AAD13998.1
    other-genetic BC111462.3 AAI11463.1
    other-genetic BC111591.2 AAI11592.1
    other-genetic BC111930.1 AAI11931.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25054.2 GenPept UniProtKB/Swiss-Prot:P25054
    Q16097 GenPept UniProtKB/TrEMBL:Q16097
    Q4LE70 GenPept UniProtKB/TrEMBL:Q4LE70
    Q5EBR9 GenPept UniProtKB/TrEMBL:Q5EBR9
    Q5EEK4 GenPept UniProtKB/TrEMBL:Q5EEK4
    Q6B4H6 GenPept UniProtKB/TrEMBL:Q6B4H6
    Q7Z2Q8 GenPept UniProtKB/TrEMBL:Q7Z2Q8
    Q9HAW6 GenPept UniProtKB/TrEMBL:Q9HAW6
    Q9P119 GenPept UniProtKB/TrEMBL:Q9P119
    Q9UM98 GenPept UniProtKB/TrEMBL:Q9UM98
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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