My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CG10992 [ Drosophila melanogaster ]

    Gene ID: 32341, updated on 10-May-2012
    Help top of page

    Summary

    Official Symbol
    CG10992provided by Flybase
    Primary source
    FLYBASE:FBgn0030521
    Locus tag
    Dmel_CG10992
    Gene type
    protein coding
    RNA name
    CG10992
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST132; CG-10992; Dmel\CG10992
    Help top of page

    Genomic context

    Location :
    12C4-12C4
    Sequence :
    Chromosome: X; NC_004354.3 (13674051..13676214, complement)
    See CG10992 in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene Yolk protein 3 Neighboring gene retinal degeneration B Neighboring gene CG11103 gene product from transcript CG11103-RB Neighboring gene inactivation no afterpotential E Neighboring gene CG10993 gene product from transcript CG10993-RA

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. Creagh EM, et al. PLoS One, 2009. PMID 19330035.
    2. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705.
    3. Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Curtis C, et al. Genome Biol, 2007. PMID 18067683.
    4. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    5. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:58714 BioGRID:62970 CG13423    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:67868 CG13630    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:59250 CG14204    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:69651 E5    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:63293 Prosbeta5R    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:62893 cer    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:64769 eyg    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:58905 mmd    BioGRID  PubMed Two-hybrid 
    BioGRID:58714 BioGRID:61853 sec24    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Homology

    • Homologs of the CG10992 gene: The CG10992 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, A.thaliana, and rice.

    Pathways from BioSystems

    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    autophagic cell death IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    salivary gland cell autophagic cell death IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    CG10992 gene product from transcript CG10992-RA
    Names
    CG10992
    CG10992-PA
    cathepsin B
    NP_572920.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      13674051..13676214, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132692.2 → NP_572920.1  CG10992 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY87
      Related
      FBpp0073669, FBtr0073838
      Conserved Domains (2) summary
      cd02620
      Location:88 – 336
      Blast Score: 933
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:24 – 65
      Blast Score: 166
      Propeptide_C1; Peptidase family C1 propeptide
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY060640.1 AAL28188.1
    genomic AE014298.4 AAF48317.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY87.1 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

      Supplemental Content

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...