socs6b suppressor of cytokine signaling 6b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: socs6bprovided by ZNC
Official Full Name: suppressor of cytokine signaling 6bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1670
See related: Ensembl:ENSDARG00000015863 AllianceGenome:ZFIN:ZDB-GENE-030131-1670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SOCS6; Socs4; socs6l; zgc:64107; wu:fb77f06
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within intracellular signal transduction; negative regulation of signal transduction; and regulation of growth. Predicted to be part of phosphatidylinositol 3-kinase complex. Orthologous to human SOCS6 (suppressor of cytokine signaling 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (30423428..30430345)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (30439895..30446812)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of growth	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: suppressor of cytokine signaling 6b

Names: suppressor of cytokine signaling 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199625.2 → NP_955919.1 suppressor of cytokine signaling 6b

See identical proteins and their annotated locations for NP_955919.1

Status: VALIDATED

Source sequence(s)

CR788254

UniProtKB/TrEMBL

B0EVP8, F6P022, Q7T2B1

Related

ENSDARP00000114806.1, ENSDART00000139871.2

Conserved Domains (2) summary

cd10387
Location:370 → 469

SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03740
Location:492 → 532

SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...