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lnpep leucyl/cystinyl aminopeptidase [ Danio rerio (zebrafish) ]

Gene ID: 322814, updated on 27-Mar-2024

Summary

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Official Symbol
lnpepprovided by ZNC
Official Full Name
leucyl/cystinyl aminopeptidaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1534
See related
Ensembl:ENSDARG00000100394 AllianceGenome:ZFIN:ZDB-GENE-030131-1534
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb73h12; zgc:66103; wu:fb73h12
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LNPEP (leucyl and cystinyl aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (52190653..52216194, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (51544093..51569577, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene SET binding protein 1 Neighboring gene solute carrier family 14 member 2 Neighboring gene endoplasmic reticulum aminopeptidase 2 Neighboring gene repulsive guidance molecule BMP co-receptor b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucyl-cystinyl aminopeptidase
NP_955915.1
XP_005165526.1
XP_021331684.1
XP_021331685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199621.1 → NP_955915.1  leucyl-cystinyl aminopeptidase

    See identical proteins and their annotated locations for NP_955915.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058317
    UniProtKB/TrEMBL
    Q6PE23
    Related
    ENSDARP00000134875.1, ENSDART00000158542.2
    Conserved Domains (3) summary
    cd09601
    Location:162 → 597
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:154 → 532
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:668 → 984
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    52190653..52216194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476010.1 → XP_021331685.1  leucyl-cystinyl aminopeptidase isoform X2

    UniProtKB/TrEMBL
    A0A8M9QDJ5
    Conserved Domains (2) summary
    cd09601
    Location:185 → 620
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:689 → 1008
    ERAP1_C; ERAP1-like C-terminal domain

  2. XM_021476009.1 → XP_021331684.1  leucyl-cystinyl aminopeptidase isoform X1

    UniProtKB/TrEMBL
    A0A2R8QBK0, A0A8M9Q2W4
    Related
    ENSDARP00000150374.1, ENSDART00000192981.1
    Conserved Domains (2) summary
    cd09601
    Location:185 → 620
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:690 → 1009
    ERAP1_C; ERAP1-like C-terminal domain

  3. XM_005165469.4 → XP_005165526.1  leucyl-cystinyl aminopeptidase isoform X3

    UniProtKB/TrEMBL
    A0A0R4IIN9, A0A8M2BCR8
    Related
    ENSDARP00000135538.1, ENSDART00000163973.2
    Conserved Domains (3) summary
    cd09601
    Location:176 → 611
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:168 → 546
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:682 → 998
    ERAP1_C; ERAP1-like C-terminal domain

RNA

  1. XR_002458738.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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