Format

Send to:

Choose Destination

HOXC10 homeobox C10 [ Homo sapiens (human) ]

Gene ID: 3226, updated on 8-May-2016
Official Symbol
HOXC10provided by HGNC
Official Full Name
homeobox C10provided by HGNC
Primary source
HGNC:HGNC:5122
See related
Ensembl:ENSG00000180818 HPRD:05710; MIM:605560; Vega:OTTHUMG00000160031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX3I
Summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (53985162..53990279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54374466..54384063)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369775 Neighboring gene homeobox C12 Neighboring gene HOX transcript antisense RNA Neighboring gene homeobox C11 Neighboring gene HOXC cluster antisense RNA 3 Neighboring gene microRNA 196a-2 Neighboring gene HOXC cluster antisense RNA 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: HOXC5

Homology

Clone Names

  • MGC5259

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with cyclin-dependent protein kinase activating kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
homeobox protein Hox-C10
Names
homeo box C10
homeobox protein Hox-3I
homeoprotein C10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017409.3NP_059105.2  homeobox protein Hox-C10

    See identical proteins and their annotated locations for NP_059105.2

    Status: REVIEWED

    Source sequence(s)
    AC012531, AL558161, BC001293
    Consensus CDS
    CCDS8868.1
    UniProtKB/Swiss-Prot
    Q9NYD6
    UniProtKB/TrEMBL
    Q53XI4
    Related
    ENSP00000307321, OTTHUMP00000217387, ENST00000303460, OTTHUMT00000358952
    Conserved Domains (1) summary
    cd00086
    Location:269327
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    53985162..53990279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    54345653..54350768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)