Pde9 Phosphodiesterase 9 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pde9provided by FlyBase
Official Full Name: Phosphodiesterase 9provided by FlyBase
Primary source: FLYBASE:FBgn0259171
Locus tag: Dmel_CG42276
See related: AllianceGenome:FB:FBgn0259171
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1627; CG32648; CG3754; CG3761; CG3765; CG42276; Dmel\CG42276; PDE9
Old locus tag: Dmel_CG32648; Dmel_CG3754
Summary: Predicted to enable 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP catabolic process and cGMP-mediated signaling. Is expressed in adult head and spermatozoon. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11C2-11D1; 1-41 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12785563..12897327, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12679596..12791360, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila genome encodes five novel PDE genes in addition to dunce. Predicted PDE sequences of Drosophila show highly conserved critical domains when compared with human PDEs.
Title: Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	ISM Inferred from Sequence Model more info	PubMed
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclic nucleotide metabolic process	ISM Inferred from Sequence Model more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: phosphodiesterase 9

Names: CG42276-PB; CG42276-PD; CG42276-PE; CG42276-PF; Pde9-PB; Pde9-PD; Pde9-PE; Pde9-PF

NP_001259495.1

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NP_001259496.1

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NP_572834.2

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NP_727644.3

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12785563..12897327 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272567.2 → NP_001259496.1 phosphodiesterase 9, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259496.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7S6

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_132606.5 → NP_572834.2 phosphodiesterase 9, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572834.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7S6

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_167340.5 → NP_727644.3 phosphodiesterase 9, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727644.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYJ0

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001272566.1 → NP_001259495.1 phosphodiesterase 9, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259495.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7S6

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase