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    Sec16 [ Drosophila melanogaster ]

    Gene ID: 32209, updated on 10-May-2012
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    Summary

    Official Symbol
    Sec16provided by Flybase
    Primary source
    FLYBASE:FBgn0052654
    Locus tag
    Dmel_CG32654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE70141; CG18079; CG2551; CG32654; Dmel\CG32654; dSec16
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    Genomic context

    Location :
    11B2-11B3
    Sequence :
    Chromosome: X; NC_004354.3 (12490106..12503943)
    See Sec16 in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene LIM-kinase1 Neighboring gene CG1824 gene product from transcript CG1824-RA Neighboring gene CG1463 gene product from transcript CG1463-RA Neighboring gene CG2543 gene product from transcript CG2543-RA Neighboring gene CG11085 gene product from transcript CG11085-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. Zacharogianni M, et al. EMBO J, 2011 Aug 16. PMID 21847093.
    2. Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. Kondylis V, et al. PLoS One, 2011 Feb 23. PMID 21383842.
    3. Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in Drosophila. Förster D, et al. Curr Biol, 2010 Jan 12. PMID 20045324.
    4. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856.
    5. Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif. Ivan V, et al. Mol Biol Cell, 2008 Oct. PMID 18614796.

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. In response to amino acid starvation, ERK7-mediated post-translational modification elicits the cytoplasmic dispersion of Sec16 and the consequent disassembly of the ER exit sites, which in turn results in protein secretion inhibition.
      Title: ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association.
    2. dSec16 binds ER cups via its arginine-rich domain, interacts with Sar1-GTP that is generated on ER membrane by Sec12 and concentrates it in the ER cups where it initiates the formation of COPII vesicles.
      Title: Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:58607 BioGRID:60309 Acer    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:65659 CG14568    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:66523 CG14711    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:78141 CG40127    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:62499 CG8414    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:59980 CG8965    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:63690 CG9149    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:61363 Df31    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:58274 Moe    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:68678 RpL10    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:66481 RpL3    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:59470 RpLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:62099 RpS11    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:59391 Sep1    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:69425 Tom40    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:59999 chic    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:68605 ci    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:60000 eIF-4a    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:60290 emb    BioGRID  PubMed Two-hybrid 
    BioGRID:58607 BioGRID:65779 lost    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum part IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG32654 gene product from transcript CG32654-RE
    Names
    CG32654-PD
    CG32654-PE
    Sec16
    Sec16-PD
    Sec16-PE
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      12490106..12503943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103493.2 → NP_001096963.1  Sec16, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUU1
      Related
      FBpp0112357, FBtr0113445
      Conserved Domains (2) summary
      cd09233
      Location:1266 – 1526
      Blast Score: 782
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl14807
      Location:1116 – 1191
      Blast Score: 109
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    2. NM_001103494.1 → NP_001096964.1  Sec16, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUU3
      Related
      FBpp0112356, FBtr0113444
      Conserved Domains (2) summary
      cd09233
      Location:1266 – 1526
      Blast Score: 775
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl14807
      Location:1116 – 1191
      Blast Score: 108
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 ABW09401.1
    genomic AE014298.4 ABW09402.1
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    Additional Links

    Gene LinkOut

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