These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029615.1 RefSeqGene
- Range
- 5001..29290
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001164.3 → NP_001155.1 amyloid beta A4 precursor protein-binding family B member 1 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as E9). This isoform is exclusively expressed in neurons.
- Source sequence(s)
-
BC010854, BG699532, L77864
- UniProtKB/Swiss-Prot
-
O00213
- Related
- ENSP00000374556, ENST00000389906
- Conserved Domains (2) summary
-
- cl00157
Location:255 – 283
Blast Score: 112
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:368 – 507
Blast Score: 481
- PH-like; Pleckstrin homology-like domain
-
NM_001257319.1 → NP_001244248.1 amyloid beta A4 precursor protein-binding family B member 1 isoform g
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) has an alternate 5' exon in place of the first two exons of variant 1. The resulting isoform (g) has a shorter and distinct N-terminus compared to isoform a.
- Source sequence(s)
-
BX538185, DC316489
- Conserved Domains (2) summary
-
- cl00157
Location:35 – 63
Blast Score: 111
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:148 – 287
Blast Score: 480
- PH-like; Pleckstrin homology-like domain
-
NM_001257320.1 → NP_001244249.1 amyloid beta A4 precursor protein-binding family B member 1 isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) has an alternate 5' exon in place of the first two exons of variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
- Source sequence(s)
-
DC303314, EF103274
- UniProtKB/TrEMBL
-
B7Z1J5
- Conserved Domains (2) summary
-
- cl00157
Location:2 – 24
Blast Score: 85
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:109 – 248
Blast Score: 481
- PH-like; Pleckstrin homology-like domain
-
NM_001257321.1 → NP_001244250.1 amyloid beta A4 precursor protein-binding family B member 1 isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) has two alternate 5' exons in place of the first two exons of variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
- Source sequence(s)
-
AK297550, DC303314, EF103274
- UniProtKB/TrEMBL
-
B7Z1J5
- Conserved Domains (2) summary
-
- cl00157
Location:2 – 24
Blast Score: 85
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:109 – 248
Blast Score: 481
- PH-like; Pleckstrin homology-like domain
-
NM_001257322.1 → NP_001244251.1 amyloid beta A4 precursor protein-binding family B member 1 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (10) has an alternate 5' exon in place of the first two exons, lacks several 3' exons, and its 3' end extends across some introns compared to variant 1. The resulting isoform (h) has shorter and distinct N- and C-termini compared to isoform a.
- Source sequence(s)
-
AK294495, AK295837, DC316489
- UniProtKB/TrEMBL
-
B7Z3G1
- Conserved Domains (2) summary
-
- cl00157
Location:35 – 63
Blast Score: 105
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:148 – 281
Blast Score: 454
- PH-like; Pleckstrin homology-like domain
-
NM_001257323.1 → NP_001244252.1 amyloid beta A4 precursor protein-binding family B member 1 isoform f
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) has an alternate 5' exon in place of the first two exons and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has a shorter and distinct N-terminus and lacks a 2 aa internal segment compared to isoform a.
- Source sequence(s)
-
AK295241, BC010854, DC316489
- UniProtKB/TrEMBL
-
B7Z2Y0
- Conserved Domains (2) summary
-
- cl00157
Location:35 – 63
Blast Score: 111
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:148 – 285
Blast Score: 494
- PH-like; Pleckstrin homology-like domain
-
NM_001257324.1 → NP_001244253.1 amyloid beta A4 precursor protein-binding family B member 1 isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks the second exon, lacks several 3' exons, and its 3' end extends across some introns compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
- Source sequence(s)
-
AK294495, BG699532
- UniProtKB/TrEMBL
-
B7Z2A2
- Conserved Domains (2) summary
-
- cl00157
Location:1 – 24
Blast Score: 80
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:109 – 242
Blast Score: 455
- PH-like; Pleckstrin homology-like domain
-
NM_001257325.1 → NP_001244254.1 amyloid beta A4 precursor protein-binding family B member 1 isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) has an alternate 5' exon in place of the first two exons of variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
- Source sequence(s)
-
AK293554, BC010854, DC319935
- Conserved Domains (2) summary
-
- cl00157
Location:20 – 48
Blast Score: 110
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:133 – 272
Blast Score: 478
- PH-like; Pleckstrin homology-like domain
-
NM_001257326.1 → NP_001244255.1 amyloid beta A4 precursor protein-binding family B member 1 isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) has an alternate 5' exon in place of the first two exons of variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
- Source sequence(s)
-
AK293550, BC010854, DC303314
- UniProtKB/TrEMBL
-
B7Z1J5
- Conserved Domains (2) summary
-
- cl00157
Location:2 – 24
Blast Score: 85
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:109 – 248
Blast Score: 481
- PH-like; Pleckstrin homology-like domain
-
NM_145689.1 → NP_663722.1 amyloid beta A4 precursor protein-binding family B member 1 isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and the coding region compared to variant 1. This results in a protein that maintains the reading frame but is a shorter isoform (b, also known as delta E9), compared to isoform a. This encoded isoform (b) is widely expressed in all non-neuronal cells, but is not expressed in differentiated neurons.
- Source sequence(s)
-
BC010854
- Consensus CDS
-
CCDS31410.1
- UniProtKB/Swiss-Prot
-
O00213
- Related
- ENSP00000311912, OTTHUMP00000229839, ENST00000311051, OTTHUMT00000384208
- Conserved Domains (2) summary
-
- cl00157
Location:255 – 283
Blast Score: 112
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:368 – 505
Blast Score: 495
- PH-like; Pleckstrin homology-like domain
RNA
-
NR_047512.1 RNA Sequence
- Description
- Transcript Variant: This variant (11) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting open reading frame (orf) has no stop codon, and no other orf is supported. Therefore, this is likely to be a non-protein coding transcript.
- Source sequence(s)
-
AF394214, BC010854, BG699532
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000011.9 Reference GRCh37.p5 Primary Assembly
- Range
- 6416355..6440644, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000143.1 Alternate HuRef
- Range
- 6075464..6099756, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)